222 related articles for article (PubMed ID: 32449077)
1. A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals.
Hanke N; Türk D; Selzer D; Ishiguro N; Ebner T; Wiebe S; Müller F; Stopfer P; Nock V; Lehr T
Clin Pharmacokinet; 2020 Nov; 59(11):1419-1431. PubMed ID: 32449077
[TBL] [Abstract][Full Text] [Related]
2. Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine.
Nishiyama K; Toshimoto K; Lee W; Ishiguro N; Bister B; Sugiyama Y
CPT Pharmacometrics Syst Pharmacol; 2019 Jun; 8(6):396-406. PubMed ID: 30821133
[TBL] [Abstract][Full Text] [Related]
3. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
Ito S; Kusuhara H; Yokochi M; Toyoshima J; Inoue K; Yuasa H; Sugiyama Y
J Pharmacol Exp Ther; 2012 Feb; 340(2):393-403. PubMed ID: 22072731
[TBL] [Abstract][Full Text] [Related]
4. Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
Elsby R; Chidlaw S; Outteridge S; Pickering S; Radcliffe A; Sullivan R; Jones H; Butler P
Pharmacol Res Perspect; 2017 Oct; 5(5):. PubMed ID: 28971610
[TBL] [Abstract][Full Text] [Related]
5. Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions.
Burt HJ; Neuhoff S; Almond L; Gaohua L; Harwood MD; Jamei M; Rostami-Hodjegan A; Tucker GT; Rowland-Yeo K
Eur J Pharm Sci; 2016 Jun; 88():70-82. PubMed ID: 27019345
[TBL] [Abstract][Full Text] [Related]
6. Effect of Cimetidine on Metformin Pharmacokinetics and Endogenous Metabolite Levels in Rats.
Ailabouni AS; Mettu VS; Thakur A; Singh DK; Prasad B
Drug Metab Dispos; 2024 Jan; 52(2):86-94. PubMed ID: 38049999
[TBL] [Abstract][Full Text] [Related]
7. Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.
Karim A; Covington P; Christopher R; Davenport M; Fleck P; Li X; Wann E; Mekki Q
Int J Clin Pharmacol Ther; 2010 Jan; 48(1):46-58. PubMed ID: 20040339
[TBL] [Abstract][Full Text] [Related]
8. Metformin-Cimetidine Drug Interaction and Risk of Lactic Acidosis in Renal Failure: A Pharmacovigilance-Pharmacokinetic Appraisal.
Xie W; Li J; Kong C; Luo W; Zheng J; Zhou Y
Diabetes Care; 2024 Jan; 47(1):144-150. PubMed ID: 37948503
[TBL] [Abstract][Full Text] [Related]
9. Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine.
Shi R; Xu Z; Xu X; Jin J; Zhao Y; Wang T; Li Y; Ma Y
Eur J Pharm Sci; 2019 Jan; 127():282-290. PubMed ID: 30428337
[TBL] [Abstract][Full Text] [Related]
10. A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug-Drug-Gene Interaction Predictions.
Türk D; Hanke N; Lehr T
Pharmaceutics; 2020 Nov; 12(11):. PubMed ID: 33182761
[TBL] [Abstract][Full Text] [Related]
11. OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine.
Wang ZJ; Yin OQ; Tomlinson B; Chow MS
Pharmacogenet Genomics; 2008 Jul; 18(7):637-45. PubMed ID: 18551044
[TBL] [Abstract][Full Text] [Related]
12. Impact of Substrate-Dependent Inhibition on Renal Organic Cation Transporters hOCT2 and hMATE1/2-K-Mediated Drug Transport and Intracellular Accumulation.
Yin J; Duan H; Wang J
J Pharmacol Exp Ther; 2016 Dec; 359(3):401-410. PubMed ID: 27758931
[TBL] [Abstract][Full Text] [Related]
13. Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells.
Tsuda M; Terada T; Ueba M; Sato T; Masuda S; Katsura T; Inui K
J Pharmacol Exp Ther; 2009 Apr; 329(1):185-91. PubMed ID: 19164462
[TBL] [Abstract][Full Text] [Related]
14. Lack of Drug-Drug Interaction Between Cimetidine, a Renal Transporter Inhibitor, and Imeglimin, a Novel Oral Antidiabetic Drug, in Healthy Volunteers.
Chevalier C; Perrimond-Dauchy S; Dubourg J; Fouqueray P; Bolze S
Eur J Drug Metab Pharmacokinet; 2020 Dec; 45(6):725-733. PubMed ID: 32860624
[TBL] [Abstract][Full Text] [Related]
15. A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators.
Yang Y; Zhang Z; Li P; Kong W; Liu X; Liu L
Pharmaceutics; 2021 May; 13(5):. PubMed ID: 34064886
[TBL] [Abstract][Full Text] [Related]
16. Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and
Jeong YS; Balla A; Chun KH; Chung SJ; Maeng HJ
Pharmaceutics; 2019 Mar; 11(3):. PubMed ID: 30845766
[TBL] [Abstract][Full Text] [Related]
17. N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.
Müller F; Pontones CA; Renner B; Mieth M; Hoier E; Auge D; Maas R; Zolk O; Fromm MF
Eur J Clin Pharmacol; 2015 Jan; 71(1):85-94. PubMed ID: 25552403
[TBL] [Abstract][Full Text] [Related]
18. A drug-drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers.
Shibata M; Toyoshima J; Kaneko Y; Oda K; Nishimura T
Eur J Clin Pharmacol; 2020 Aug; 76(8):1135-1141. PubMed ID: 32472157
[TBL] [Abstract][Full Text] [Related]
19. Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Wiebe ST; Giessmann T; Hohl K; Schmidt-Gerets S; Hauel E; Jambrecina A; Bader K; Ishiguro N; Taub ME; Sharma A; Ebner T; Mikus G; Fromm MF; Müller F; Stopfer P
Clin Pharmacokinet; 2020 Dec; 59(12):1627-1639. PubMed ID: 32504272
[TBL] [Abstract][Full Text] [Related]
20. Evaluation of the potential interaction between tofacitinib and drugs that undergo renal tubular secretion using metformin, an in vivo marker of renal organic cation transporter 2.
Klamerus KJ; Alvey C; Li L; Feng B; Wang R; Kaplan I; Shi H; Dowty ME; Krishnaswami S
Clin Pharmacol Drug Dev; 2014 Nov; 3(6):499-507. PubMed ID: 27129125
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
