BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

277 related articles for article (PubMed ID: 32451425)

  • 1. Gene expression regulation by CDK12: a versatile kinase in cancer with functions beyond CTD phosphorylation.
    Choi SH; Kim S; Jones KA
    Exp Mol Med; 2020 May; 52(5):762-771. PubMed ID: 32451425
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.
    Cheng SW; Kuzyk MA; Moradian A; Ichu TA; Chang VC; Tien JF; Vollett SE; Griffith M; Marra MA; Morin GB
    Mol Cell Biol; 2012 Nov; 32(22):4691-704. PubMed ID: 22988298
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Role and therapeutic potential of CDK12 in human cancers.
    Chilà R; Guffanti F; Damia G
    Cancer Treat Rev; 2016 Nov; 50():83-88. PubMed ID: 27662623
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation.
    Tellier M; Zaborowska J; Caizzi L; Mohammad E; Velychko T; Schwalb B; Ferrer-Vicens I; Blears D; Nojima T; Cramer P; Murphy S
    Nucleic Acids Res; 2020 Aug; 48(14):7712-7727. PubMed ID: 32805052
    [TBL] [Abstract][Full Text] [Related]  

  • 5.
    Liang S; Hu L; Wu Z; Chen Z; Liu S; Xu X; Qian A
    Cells; 2020 Jun; 9(6):. PubMed ID: 32570740
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CDK12: an emerging therapeutic target for cancer.
    Lui GYL; Grandori C; Kemp CJ
    J Clin Pathol; 2018 Nov; 71(11):957-962. PubMed ID: 30104286
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium.
    Greenleaf AL
    Transcription; 2019 Apr; 10(2):91-110. PubMed ID: 30319007
    [TBL] [Abstract][Full Text] [Related]  

  • 8. CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
    Chirackal Manavalan AP; Pilarova K; Kluge M; Bartholomeeusen K; Rajecky M; Oppelt J; Khirsariya P; Paruch K; Krejci L; Friedel CC; Blazek D
    EMBO Rep; 2019 Sep; 20(9):e47592. PubMed ID: 31347271
    [TBL] [Abstract][Full Text] [Related]  

  • 9. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
    Dubbury SJ; Boutz PL; Sharp PA
    Nature; 2018 Dec; 564(7734):141-145. PubMed ID: 30487607
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The structure and substrate specificity of human Cdk12/Cyclin K.
    Bösken CA; Farnung L; Hintermair C; Merzel Schachter M; Vogel-Bachmayr K; Blazek D; Anand K; Fisher RP; Eick D; Geyer M
    Nat Commun; 2014 Mar; 5():3505. PubMed ID: 24662513
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
    Blazek D; Kohoutek J; Bartholomeeusen K; Johansen E; Hulinkova P; Luo Z; Cimermancic P; Ule J; Peterlin BM
    Genes Dev; 2011 Oct; 25(20):2158-72. PubMed ID: 22012619
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.
    Liang K; Gao X; Gilmore JM; Florens L; Washburn MP; Smith E; Shilatifard A
    Mol Cell Biol; 2015 Mar; 35(6):928-38. PubMed ID: 25561469
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs.
    Guo Z; Stiller JW
    BMC Genomics; 2004 Sep; 5():69. PubMed ID: 15380029
    [TBL] [Abstract][Full Text] [Related]  

  • 14. CDK12: a potential therapeutic target in cancer.
    Emadi F; Teo T; Rahaman MH; Wang S
    Drug Discov Today; 2020 Dec; 25(12):2257-2267. PubMed ID: 33038524
    [TBL] [Abstract][Full Text] [Related]  

  • 15. CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.
    Qiu M; Yin Z; Wang H; Lei L; Li C; Cui Y; Dai R; Yang P; Xiang Y; Li Q; Lv J; Hu Z; Chen M; Zhou HB; Fang P; Xiao R; Liang K
    Sci Adv; 2023 May; 9(20):eadf8698. PubMed ID: 37205756
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.
    Bartkowiak B; Greenleaf AL
    J Biol Chem; 2015 Jan; 290(3):1786-95. PubMed ID: 25429106
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The emerging roles of CDK12 in tumorigenesis.
    Paculová H; Kohoutek J
    Cell Div; 2017; 12():7. PubMed ID: 29090014
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.
    Choi SH; Martinez TF; Kim S; Donaldson C; Shokhirev MN; Saghatelian A; Jones KA
    Genes Dev; 2019 Apr; 33(7-8):418-435. PubMed ID: 30819820
    [TBL] [Abstract][Full Text] [Related]  

  • 19. CDK12 Is Necessary to Promote Epidermal Differentiation Through Transcription Elongation.
    Li J; Tiwari M; Chen Y; Luanpitpong S; Sen GL
    Stem Cells; 2022 Apr; 40(4):435-445. PubMed ID: 35325240
    [TBL] [Abstract][Full Text] [Related]  

  • 20. RNA polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation: A tail of two kinases.
    Bowman EA; Kelly WG
    Nucleus; 2014; 5(3):224-36. PubMed ID: 24879308
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.