241 related articles for article (PubMed ID: 32453400)
1. Inhibitors in AKTion: ATP-competitive vs allosteric.
Lazaro G; Kostaras E; Vivanco I
Biochem Soc Trans; 2020 Jun; 48(3):933-943. PubMed ID: 32453400
[TBL] [Abstract][Full Text] [Related]
2. The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.
Lindsley CW; Barnett SF; Layton ME; Bilodeau MT
Curr Cancer Drug Targets; 2008 Feb; 8(1):7-18. PubMed ID: 18288939
[TBL] [Abstract][Full Text] [Related]
3. Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review).
Nitulescu GM; Margina D; Juzenas P; Peng Q; Olaru OT; Saloustros E; Fenga C; Spandidos DΑ; Libra M; Tsatsakis AM
Int J Oncol; 2016 Mar; 48(3):869-85. PubMed ID: 26698230
[TBL] [Abstract][Full Text] [Related]
4. Developments in selective small molecule ATP-targeting the serine/threonine kinase Akt/PKB.
Wang P; Zhang L; Hao Q; Zhao G
Mini Rev Med Chem; 2011 Nov; 11(13):1093-107. PubMed ID: 22353219
[TBL] [Abstract][Full Text] [Related]
5. Picking the point of inhibition: a comparative review of PI3K/AKT/mTOR pathway inhibitors.
Dienstmann R; Rodon J; Serra V; Tabernero J
Mol Cancer Ther; 2014 May; 13(5):1021-31. PubMed ID: 24748656
[TBL] [Abstract][Full Text] [Related]
6. Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.
Savill KMZ; Lee BB; Oeh J; Lin J; Lin E; Chung WJ; Young A; Chen W; Miś M; Mesh K; Eastham J; Gnad F; Jiang Z; Stawiski EW; Haley B; Daemen A; Wang X; Koeppen H; Modrusan Z; Martin SE; Sampath D; Lin K
Nat Commun; 2022 Apr; 13(1):2057. PubMed ID: 35440108
[TBL] [Abstract][Full Text] [Related]
7. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications.
Carnero A; Blanco-Aparicio C; Renner O; Link W; Leal JF
Curr Cancer Drug Targets; 2008 May; 8(3):187-98. PubMed ID: 18473732
[TBL] [Abstract][Full Text] [Related]
8. Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia.
Badura S; Tesanovic T; Pfeifer H; Wystub S; Nijmeijer BA; Liebermann M; Falkenburg JH; Ruthardt M; Ottmann OG
PLoS One; 2013; 8(11):e80070. PubMed ID: 24244612
[TBL] [Abstract][Full Text] [Related]
9. Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.
Lindsley CW; Barnett SF; Yaroschak M; Bilodeau MT; Layton ME
Curr Top Med Chem; 2007; 7(14):1349-63. PubMed ID: 17692025
[TBL] [Abstract][Full Text] [Related]
10. Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents.
Liu Y; Wan WZ; Li Y; Zhou GL; Liu XG
Oncotarget; 2017 Jan; 8(4):7181-7200. PubMed ID: 27769061
[TBL] [Abstract][Full Text] [Related]
11. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.
Dumble M; Crouthamel MC; Zhang SY; Schaber M; Levy D; Robell K; Liu Q; Figueroa DJ; Minthorn EA; Seefeld MA; Rouse MB; Rabindran SK; Heerding DA; Kumar R
PLoS One; 2014; 9(6):e100880. PubMed ID: 24978597
[TBL] [Abstract][Full Text] [Related]
12. Advances towards the development of ATP-competitive small-molecule inhibitors of the insulin-like growth factor receptor (IGF-IR).
Hubbard RD; Wilsbacher JL
ChemMedChem; 2007 Jan; 2(1):41-6. PubMed ID: 17089440
[No Abstract] [Full Text] [Related]
13. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy.
Ksionda O; Mues M; Wandler AM; Donker L; Tenhagen M; Jun J; Ducker GS; Matlawska-Wasowska K; Shannon K; Shokat KM; Roose JP
PLoS One; 2018; 13(5):e0193849. PubMed ID: 29799846
[TBL] [Abstract][Full Text] [Related]
14. High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors.
Smit DJ; Cayrefourcq L; Haider MT; Hinz N; Pantel K; Alix-Panabières C; Jücker M
Cells; 2020 Sep; 9(9):. PubMed ID: 32962206
[TBL] [Abstract][Full Text] [Related]
15. New inhibitors of the mammalian target of rapamycin signaling pathway for cancer.
Albert S; Serova M; Dreyer C; Sablin MP; Faivre S; Raymond E
Expert Opin Investig Drugs; 2010 Aug; 19(8):919-30. PubMed ID: 20569080
[TBL] [Abstract][Full Text] [Related]
16. Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance.
Ediriweera MK; Tennekoon KH; Samarakoon SR
Semin Cancer Biol; 2019 Dec; 59():147-160. PubMed ID: 31128298
[TBL] [Abstract][Full Text] [Related]
17. Microsecond molecular dynamics simulations provide insight into the ATP-competitive inhibitor-induced allosteric protection of Akt kinase phosphorylation.
Mou L; Cui T; Liu W; Zhang H; Cai Z; Lu S; Gao G
Chem Biol Drug Des; 2017 May; 89(5):723-731. PubMed ID: 27797456
[TBL] [Abstract][Full Text] [Related]
18. A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity.
Kostaras E; Kaserer T; Lazaro G; Heuss SF; Hussain A; Casado P; Hayes A; Yandim C; Palaskas N; Yu Y; Schwartz B; Raynaud F; Chung YL; Cutillas PR; Vivanco I
Br J Cancer; 2020 Aug; 123(4):542-555. PubMed ID: 32439931
[TBL] [Abstract][Full Text] [Related]
19. Targeting PI3K/Akt signal transduction for cancer therapy.
He Y; Sun MM; Zhang GG; Yang J; Chen KS; Xu WW; Li B
Signal Transduct Target Ther; 2021 Dec; 6(1):425. PubMed ID: 34916492
[TBL] [Abstract][Full Text] [Related]
20. Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells.
Yu X; Xu J; Cahuzac KM; Xie L; Shen Y; Chen X; Liu J; Parsons RE; Jin J
J Med Chem; 2022 Oct; 65(20):14237-14260. PubMed ID: 36197750
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
