BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

210 related articles for article (PubMed ID: 32457458)

  • 21. Hypoxia Induces Production of L-2-Hydroxyglutarate.
    Intlekofer AM; Dematteo RG; Venneti S; Finley LW; Lu C; Judkins AR; Rustenburg AS; Grinaway PB; Chodera JD; Cross JR; Thompson CB
    Cell Metab; 2015 Aug; 22(2):304-11. PubMed ID: 26212717
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations.
    Intlekofer AM; Shih AH; Wang B; Nazir A; Rustenburg AS; Albanese SK; Patel M; Famulare C; Correa FM; Takemoto N; Durani V; Liu H; Taylor J; Farnoud N; Papaemmanuil E; Cross JR; Tallman MS; Arcila ME; Roshal M; Petsko GA; Wu B; Choe S; Konteatis ZD; Biller SA; Chodera JD; Thompson CB; Levine RL; Stein EM
    Nature; 2018 Jul; 559(7712):125-129. PubMed ID: 29950729
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.
    Kingsbury JM; Shamaprasad N; Billmyre RB; Heitman J; Cardenas ME
    Hum Mol Genet; 2016 Aug; 25(16):3524-3538. PubMed ID: 27427385
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics.
    Xu Y; Liu L; Nakamura A; Someya S; Miyakawa T; Tanokura M
    Sci Rep; 2017 Aug; 7(1):9785. PubMed ID: 28852116
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
    Showalter MR; Hatakeyama J; Cajka T; VanderVorst K; Carraway KL; Fiehn O;
    Elife; 2017 Jun; 6():. PubMed ID: 28653623
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.
    Rendina AR; Pietrak B; Smallwood A; Zhao H; Qi H; Quinn C; Adams ND; Concha N; Duraiswami C; Thrall SH; Sweitzer S; Schwartz B
    Biochemistry; 2013 Jul; 52(26):4563-77. PubMed ID: 23731180
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Isocitrate dehydrogenase variants in cancer - Cellular consequences and therapeutic opportunities.
    Liu S; Cadoux-Hudson T; Schofield CJ
    Curr Opin Chem Biol; 2020 Aug; 57():122-134. PubMed ID: 32777735
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Mitochondrial NADP
    Kong MJ; Han SJ; Kim JI; Park JW; Park KM
    Cell Death Dis; 2018 May; 9(5):488. PubMed ID: 29695796
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells.
    Chen D; Xia S; Zhang R; Li Y; Famulare CA; Fan H; Wu R; Wang M; Zhu AC; Elf SE; Su R; Dong L; Arellano M; Blum WG; Mao H; Lonial S; Stock W; Odenike O; Le Beau M; Boggon TJ; He C; Chen J; Gao X; Levine RL; Chen J
    Mol Cell; 2021 Sep; 81(18):3833-3847.e11. PubMed ID: 34289383
    [TBL] [Abstract][Full Text] [Related]  

  • 30. D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH.
    Oizel K; Gratas C; Nadaradjane A; Oliver L; Vallette FM; Pecqueur C
    Cell Death Dis; 2015 Mar; 6(3):e1704. PubMed ID: 25811801
    [TBL] [Abstract][Full Text] [Related]  

  • 31. SIRT3 deacetylated and increased citrate synthase activity in PD model.
    Cui XX; Li X; Dong SY; Guo YJ; Liu T; Wu YC
    Biochem Biophys Res Commun; 2017 Mar; 484(4):767-773. PubMed ID: 28161643
    [TBL] [Abstract][Full Text] [Related]  

  • 32. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.
    Losman JA; Looper RE; Koivunen P; Lee S; Schneider RK; McMahon C; Cowley GS; Root DE; Ebert BL; Kaelin WG
    Science; 2013 Mar; 339(6127):1621-5. PubMed ID: 23393090
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.
    Badur MG; Muthusamy T; Parker SJ; Ma S; McBrayer SK; Cordes T; Magana JH; Guan KL; Metallo CM
    Cell Rep; 2018 Oct; 25(4):1018-1026.e4. PubMed ID: 30355481
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discordant intracellular and plasma D-2-hydroxyglutarate levels in a patient with IDH2 mutated angioimmunoblastic T-cell lymphoma.
    Churchill H; Naina H; Boriack R; Rakheja D; Chen W
    Int J Clin Exp Pathol; 2015; 8(9):11753-9. PubMed ID: 26617922
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Biochemical Background in Mitochondria Affects 2HG Production by IDH2 and ADHFE1 in Breast Carcinoma.
    Špačková J; Gotvaldová K; Dvořák A; Urbančoková A; Pospíšilová K; Větvička D; Leguina-Ruzzi A; Tesařová P; Vítek L; Ježek P; Smolková K
    Cancers (Basel); 2021 Apr; 13(7):. PubMed ID: 33916579
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.
    Borger DR; Goyal L; Yau T; Poon RT; Ancukiewicz M; Deshpande V; Christiani DC; Liebman HM; Yang H; Kim H; Yen K; Faris JE; Iafrate AJ; Kwak EL; Clark JW; Allen JN; Blaszkowsky LS; Murphy JE; Saha SK; Hong TS; Wo JY; Ferrone CR; Tanabe KK; Bardeesy N; Straley KS; Agresta S; Schenkein DP; Ellisen LW; Ryan DP; Zhu AX
    Clin Cancer Res; 2014 Apr; 20(7):1884-90. PubMed ID: 24478380
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
    Jin G; Reitman ZJ; Duncan CG; Spasojevic I; Gooden DM; Rasheed BA; Yang R; Lopez GY; He Y; McLendon RE; Bigner DD; Yan H
    Cancer Res; 2013 Jan; 73(2):496-501. PubMed ID: 23204232
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.
    Nadtochiy SM; Wang YT; Zhang J; Nehrke K; Schafer X; Welle K; Ghaemmaghami S; Munger J; Brookes PS
    Biochem J; 2017 Aug; 474(16):2829-2839. PubMed ID: 28673962
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.
    Reitman ZJ; Sinenko SA; Spana EP; Yan H
    Blood; 2015 Jan; 125(2):336-45. PubMed ID: 25398939
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.
    Reitman ZJ; Jin G; Karoly ED; Spasojevic I; Yang J; Kinzler KW; He Y; Bigner DD; Vogelstein B; Yan H
    Proc Natl Acad Sci U S A; 2011 Feb; 108(8):3270-5. PubMed ID: 21289278
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 11.