BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

287 related articles for article (PubMed ID: 32459374)

  • 1. Small-Molecule Inhibitors Targeting Sterol 14α-Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans.
    Binjubair FA; Parker JE; Warrilow AG; Puri K; Braidley PJ; Tatar E; Kelly SL; Kelly DE; Simons C
    ChemMedChem; 2020 Jul; 15(14):1294-1309. PubMed ID: 32459374
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis.
    Friggeri L; Hargrove TY; Wawrzak Z; Blobaum AL; Rachakonda G; Lindsley CW; Villalta F; Nes WD; Botta M; Guengerich FP; Lepesheva GI
    J Med Chem; 2018 Jul; 61(13):5679-5691. PubMed ID: 29894182
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.
    Warrilow AG; Hull CM; Parker JE; Garvey EP; Hoekstra WJ; Moore WR; Schotzinger RJ; Kelly DE; Kelly SL
    Antimicrob Agents Chemother; 2014 Dec; 58(12):7121-7. PubMed ID: 25224009
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pyridylethanol(phenylethyl)amines are non-azole, highly selective Candida albicans sterol 14α-demethylase inhibitors.
    Ogris I; Zelenko U; Sosič I; Gobec M; Skubic C; Ivanov M; Soković M; Kocjan D; Rozman D; Golič Grdadolnik S
    Bioorg Chem; 2021 Jan; 106():104472. PubMed ID: 33261849
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural analyses of
    Hargrove TY; Friggeri L; Wawrzak Z; Qi A; Hoekstra WJ; Schotzinger RJ; York JD; Guengerich FP; Lepesheva GI
    J Biol Chem; 2017 Apr; 292(16):6728-6743. PubMed ID: 28258218
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Evolution of Azole Resistance in
    Warrilow AG; Nishimoto AT; Parker JE; Price CL; Flowers SA; Kelly DE; Rogers PD; Kelly SL
    Antimicrob Agents Chemother; 2019 May; 63(5):. PubMed ID: 30783005
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and optimization of highly-selective fungal CYP51 inhibitors.
    Hoekstra WJ; Garvey EP; Moore WR; Rafferty SW; Yates CM; Schotzinger RJ
    Bioorg Med Chem Lett; 2014 Aug; 24(15):3455-8. PubMed ID: 24948565
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nitrate Esters of Heteroaromatic Compounds as Candida albicans CYP51 Enzyme Inhibitors.
    Smiljkovic M; Matsoukas MT; Kritsi E; Zelenko U; Grdadolnik SG; Calhelha RC; Ferreira ICFR; Sankovic-Babic S; Glamoclija J; Fotopoulou T; Koufaki M; Zoumpoulakis P; Sokovic M
    ChemMedChem; 2018 Feb; 13(3):251-258. PubMed ID: 29235267
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance.
    Alvarez-Rueda N; Fleury A; Logé C; Pagniez F; Robert E; Morio F; Le Pape P
    Med Mycol; 2016 Oct; 54(7):764-775. PubMed ID: 27143634
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents.
    Jiang Y; Zhang J; Cao Y; Chai X; Zou Y; Wu Q; Zhang D; Jiang Y; Sun Q
    Bioorg Med Chem Lett; 2011 Aug; 21(15):4471-5. PubMed ID: 21737273
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51).
    Warrilow AG; Hull CM; Rolley NJ; Parker JE; Nes WD; Smith SN; Kelly DE; Kelly SL
    Appl Environ Microbiol; 2014 Oct; 80(19):6154-66. PubMed ID: 25085484
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antifungal screening and in silico mechanistic studies of an in-house azole library.
    Sari S; Kart D; Sabuncuoğlu S; Doğan İS; Özdemir Z; Bozbey İ; Gencel M; Eşsiz Ş; Reynisson J; Karakurt A; Saraç S; Dalkara S
    Chem Biol Drug Des; 2019 Sep; 94(5):1944-1955. PubMed ID: 31260179
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and in vitro antifungal activity of 1-[(4-substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols.
    Guillon R; Pagniez F; Giraud F; Crépin D; Picot C; Le Borgne M; Morio F; Duflos M; Logé C; Le Pape P
    ChemMedChem; 2011 May; 6(5):816-25. PubMed ID: 21370476
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery of new azoles with potent activity against Candida spp. and Candida albicans biofilms through virtual screening.
    Sari S; Kart D; Öztürk N; Kaynak FB; Gencel M; Taşkor G; Karakurt A; Saraç S; Eşsiz Ş; Dalkara S
    Eur J Med Chem; 2019 Oct; 179():634-648. PubMed ID: 31279296
    [TBL] [Abstract][Full Text] [Related]  

  • 15. S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.
    Warrilow AG; Mullins JG; Hull CM; Parker JE; Lamb DC; Kelly DE; Kelly SL
    Antimicrob Agents Chemother; 2012 Apr; 56(4):2099-107. PubMed ID: 22252802
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In silico and in vitro screening to identify structurally diverse non-azole CYP51 inhibitors as potent antifungal agent.
    Singh A; Paliwal SK; Sharma M; Mittal A; Sharma S; Sharma JP
    J Mol Graph Model; 2016 Jan; 63():1-7. PubMed ID: 26579619
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one.
    Jiang Y; Cao Y; Zhang J; Zou Y; Chai X; Hu H; Zhao Q; Wu Q; Zhang D; Jiang Y; Sun Q
    Eur J Med Chem; 2011 Jul; 46(7):3135-41. PubMed ID: 21354675
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis and antifungal activity of some new imidazole and triazole derivatives.
    Rezaei Z; Khabnadideh S; Zomorodian K; Pakshir K; Kashi G; Sanagoei N; Gholami S
    Arch Pharm (Weinheim); 2011 Oct; 344(10):658-65. PubMed ID: 21984016
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular Docking Evaluation of Imidazole Analogues as Potent Candida albicans 14α-Demethylase Inhibitors.
    Rani N; Kumar P; Singh R; Sharma A
    Curr Comput Aided Drug Des; 2015; 11(1):8-20. PubMed ID: 26081558
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
    Devadas B; Freeman SK; Zupec ME; Lu HF; Nagarajan SR; Kishore NS; Lodge JK; Kuneman DW; McWherter CA; Vinjamoori DV; Getman DP; Gordon JI; Sikorski JA
    J Med Chem; 1997 Aug; 40(16):2609-25. PubMed ID: 9258368
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.