These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

145 related articles for article (PubMed ID: 32484077)

  • 1. Optimized High-Yield Purification of Obesity-Associated Melanocortin 4 Receptor.
    Kim M; Jo S; Jeong JH; Kim Y
    Protein Pept Lett; 2021; 28(1):63-73. PubMed ID: 32484077
    [TBL] [Abstract][Full Text] [Related]  

  • 2. High-level expression and purification of the second transmembrane domain of wild-type and mutant human melanocortin-4 receptor for solid-state NMR structural studies.
    Park TJ; Choi SS; Gang GA; Kim Y
    Protein Expr Purif; 2008 Dec; 62(2):139-45. PubMed ID: 18809499
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling.
    Chen M; Cai M; Aprahamian CJ; Georgeson KE; Hruby V; Harmon CM; Yang Y
    J Biol Chem; 2007 Jul; 282(30):21712-9. PubMed ID: 17545153
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Solution structure of the transmembrane 2 domain of the human melanocortin-4 receptor in sodium dodecyl sulfate (SDS) micelles and the functional implication of the D90N mutant.
    Yun JH; Kim M; Kim K; Lee D; Jung Y; Oh D; Ko YJ; Cho AE; Cho HS; Lee W
    Biochim Biophys Acta; 2015 Jun; 1848(6):1294-302. PubMed ID: 25753114
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.
    René P; Lanfray D; Richard D; Bouvier M
    JCI Insight; 2021 Feb; 6(4):. PubMed ID: 33434184
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling.
    Yang Y; Cai M; Chen M; Qu H; McPherson D; Hruby V; Harmon CM
    Regul Pept; 2009 Jun; 155(1-3):46-54. PubMed ID: 19303903
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach.
    Falls BA; Zhang Y
    ACS Chem Neurosci; 2019 Mar; 10(3):1055-1065. PubMed ID: 30048591
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.
    Yun JH; Kim K; Jung Y; Park JH; Cho HS; Lee W
    Biochem Biophys Res Commun; 2015 Jan; 456(1):116-21. PubMed ID: 25446108
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular basis of melanocortin-4 receptor for AGRP inverse agonism.
    Chen M; Celik A; Georgeson KE; Harmon CM; Yang Y
    Regul Pept; 2006 Sep; 136(1-3):40-9. PubMed ID: 16820227
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel pharmacological MC4R agonists can efficiently activate mutated MC4R from obese patient with impaired endogenous agonist response.
    Roubert P; Dubern B; Plas P; Lubrano-Berthelier C; Alihi R; Auger F; Deoliveira DB; Dong JZ; Basdevant A; Thurieau C; Clément K
    J Endocrinol; 2010 Nov; 207(2):177-83. PubMed ID: 20696697
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.
    Tan K; Pogozheva ID; Yeo GS; Hadaschik D; Keogh JM; Haskell-Leuvano C; O'Rahilly S; Mosberg HI; Farooqi IS
    Endocrinology; 2009 Jan; 150(1):114-25. PubMed ID: 18801902
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity.
    Chen M; Cai M; McPherson D; Hruby V; Harmon CM; Yang Y
    Biochem Pharmacol; 2009 Jan; 77(1):114-24. PubMed ID: 18930713
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Autosomal-dominant mode of inheritance of a melanocortin-4 receptor mutation in a patient with severe early-onset obesity is due to a dominant-negative effect caused by receptor dimerization.
    Biebermann H; Krude H; Elsner A; Chubanov V; Gudermann T; Grüters A
    Diabetes; 2003 Dec; 52(12):2984-8. PubMed ID: 14633860
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activity.
    Yang Y; Chen M; Lai Y; Gantz I; Georgeson KE; Harmon CM
    J Biol Chem; 2002 Jun; 277(23):20328-35. PubMed ID: 11912210
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Expression and biophysical analysis of two double-transmembrane domain-containing fragments from a yeast G protein-coupled receptor.
    Cohen LS; Arshava B; Estephan R; Englander J; Kim H; Hauser M; Zerbe O; Ceruso M; Becker JM; Naider F
    Biopolymers; 2008; 90(2):117-30. PubMed ID: 18260136
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cloning, expression, isotope labeling, purification, and characterization of bovine antimicrobial peptide, lactophoricin in Escherichia coli.
    Park TJ; Kim JS; Choi SS; Kim Y
    Protein Expr Purif; 2009 May; 65(1):23-9. PubMed ID: 19130889
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular determination of agouti-related protein binding to human melanocortin-4 receptor.
    Yang Y; Chen M; Lai Y; Gantz I; Yagmurlu A; Georgeson KE; Harmon CM
    Mol Pharmacol; 2003 Jul; 64(1):94-103. PubMed ID: 12815165
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor.
    Ying J; Gu X; Cai M; Dedek M; Vagner J; Trivedi DB; Hruby VJ
    J Med Chem; 2006 Nov; 49(23):6888-96. PubMed ID: 17154518
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Functional characterization and pharmacological rescue of melanocortin-4 receptor mutations identified from obese patients.
    Fan ZC; Tao YX
    J Cell Mol Med; 2009 Sep; 13(9B):3268-82. PubMed ID: 19298524
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.
    Ericson MD; Haslach EM; Schnell SM; Freeman KT; Xiang ZM; Portillo FP; Speth R; Litherland SA; Haskell-Luevano C
    ACS Chem Neurosci; 2021 Feb; 12(3):542-556. PubMed ID: 33470098
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.