362 related articles for article (PubMed ID: 32511987)
1. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na
Rupasinghe DB; Herzig V; Vetter I; Dekan Z; Gilchrist J; Bosmans F; Alewood PF; Lewis RJ; King GF
Biochem Pharmacol; 2020 Nov; 181():114080. PubMed ID: 32511987
[TBL] [Abstract][Full Text] [Related]
2. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
Cardoso FC; Dekan Z; Rosengren KJ; Erickson A; Vetter I; Deuis JR; Herzig V; Alewood PF; King GF; Lewis RJ
Mol Pharmacol; 2015 Aug; 88(2):291-303. PubMed ID: 25979003
[TBL] [Abstract][Full Text] [Related]
3. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
Chow CY; Cristofori-Armstrong B; Undheim EA; King GF; Rash LD
Toxins (Basel); 2015 Jun; 7(7):2494-513. PubMed ID: 26134258
[TBL] [Abstract][Full Text] [Related]
4. Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
Moyer BD; Murray JK; Ligutti J; Andrews K; Favreau P; Jordan JB; Lee JH; Liu D; Long J; Sham K; Shi L; Stöcklin R; Wu B; Yin R; Yu V; Zou A; Biswas K; Miranda LP
PLoS One; 2018; 13(5):e0196791. PubMed ID: 29723257
[TBL] [Abstract][Full Text] [Related]
5. Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.
Cardoso FC; Dekan Z; Smith JJ; Deuis JR; Vetter I; Herzig V; Alewood PF; King GF; Lewis RJ
Br J Pharmacol; 2017 Aug; 174(15):2528-2544. PubMed ID: 28542706
[TBL] [Abstract][Full Text] [Related]
6. A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.
Gui J; Liu B; Cao G; Lipchik AM; Perez M; Dekan Z; Mobli M; Daly NL; Alewood PF; Parker LL; King GF; Zhou Y; Jordt SE; Nitabach MN
Curr Biol; 2014 Mar; 24(5):473-83. PubMed ID: 24530065
[TBL] [Abstract][Full Text] [Related]
7. Chemical Synthesis, Proper Folding, Na
Nicolas S; Zoukimian C; Bosmans F; Montnach J; Diochot S; Cuypers E; De Waard S; Béroud R; Mebs D; Craik D; Boturyn D; Lazdunski M; Tytgat J; De Waard M
Toxins (Basel); 2019 Jun; 11(6):. PubMed ID: 31234412
[TBL] [Abstract][Full Text] [Related]
8. Evaluation of the Spider (
Gonçalves TC; Lesport P; Kuylle S; Stura E; Ciolek J; Mourier G; Servent D; Bourinet E; Benoit E; Gilles N
Toxins (Basel); 2019 Aug; 11(9):. PubMed ID: 31443554
[TBL] [Abstract][Full Text] [Related]
9. Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNa
Neff RA; Flinspach M; Gibbs A; Shih AY; Minassian NA; Liu Y; Fellows R; Libiger O; Young S; Pennington MW; Hunter MJ; Wickenden AD
J Biol Chem; 2020 Jan; 295(5):1315-1327. PubMed ID: 31871053
[TBL] [Abstract][Full Text] [Related]
10. Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7.
Klint JK; Chin YK; Mobli M
Mol Pharmacol; 2015 Dec; 88(6):1002-10. PubMed ID: 26429937
[TBL] [Abstract][Full Text] [Related]
11. Two tarantula peptides inhibit activation of multiple sodium channels.
Middleton RE; Warren VA; Kraus RL; Hwang JC; Liu CJ; Dai G; Brochu RM; Kohler MG; Gao YD; Garsky VM; Bogusky MJ; Mehl JT; Cohen CJ; Smith MM
Biochemistry; 2002 Dec; 41(50):14734-47. PubMed ID: 12475222
[TBL] [Abstract][Full Text] [Related]
12. Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.
Klint JK; Smith JJ; Vetter I; Rupasinghe DB; Er SY; Senff S; Herzig V; Mobli M; Lewis RJ; Bosmans F; King GF
Br J Pharmacol; 2015 May; 172(10):2445-58. PubMed ID: 25754331
[TBL] [Abstract][Full Text] [Related]
13. Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi.
Sousa SR; Wingerd JS; Brust A; Bladen C; Ragnarsson L; Herzig V; Deuis JR; Dutertre S; Vetter I; Zamponi GW; King GF; Alewood PF; Lewis RJ
PLoS One; 2017; 12(9):e0182848. PubMed ID: 28880874
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.
Sokolov S; Kraus RL; Scheuer T; Catterall WA
Mol Pharmacol; 2008 Mar; 73(3):1020-8. PubMed ID: 18156314
[TBL] [Abstract][Full Text] [Related]
15. Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors.
Peigneur S; Cheneval O; Maiti M; Leipold E; Heinemann SH; Lescrinier E; Herdewijn P; De Lima ME; Craik DJ; Schroeder CI; Tytgat J
FASEB J; 2019 Mar; 33(3):3693-3703. PubMed ID: 30509130
[TBL] [Abstract][Full Text] [Related]
16. ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.
Schmalhofer WA; Calhoun J; Burrows R; Bailey T; Kohler MG; Weinglass AB; Kaczorowski GJ; Garcia ML; Koltzenburg M; Priest BT
Mol Pharmacol; 2008 Nov; 74(5):1476-84. PubMed ID: 18728100
[TBL] [Abstract][Full Text] [Related]
17. Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes.
Agwa AJ; Peigneur S; Chow CY; Lawrence N; Craik DJ; Tytgat J; King GF; Henriques ST; Schroeder CI
J Biol Chem; 2018 Jun; 293(23):9041-9052. PubMed ID: 29703751
[TBL] [Abstract][Full Text] [Related]
18. Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.
Yang S; Xiao Y; Kang D; Liu J; Li Y; Undheim EA; Klint JK; Rong M; Lai R; King GF
Proc Natl Acad Sci U S A; 2013 Oct; 110(43):17534-9. PubMed ID: 24082113
[TBL] [Abstract][Full Text] [Related]
19. The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.
Xiao Y; Blumenthal K; Jackson JO; Liang S; Cummins TR
Mol Pharmacol; 2010 Dec; 78(6):1124-34. PubMed ID: 20855463
[TBL] [Abstract][Full Text] [Related]
20. ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels.
Priest BT; Blumenthal KM; Smith JJ; Warren VA; Smith MM
Toxicon; 2007 Feb; 49(2):194-201. PubMed ID: 17087985
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
