170 related articles for article (PubMed ID: 32530623)
1. Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6
Ferguson FM; Liu Y; Harshbarger W; Huang L; Wang J; Deng X; Capuzzi SJ; Muratov EN; Tropsha A; Muthuswamy S; Westover KD; Gray NS
J Med Chem; 2020 Jul; 63(14):7817-7826. PubMed ID: 32530623
[TBL] [Abstract][Full Text] [Related]
2. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1.
Weygant N; Qu D; Berry WL; May R; Chandrakesan P; Owen DB; Sureban SM; Ali N; Janknecht R; Houchen CW
Mol Cancer; 2014 May; 13():103. PubMed ID: 24885928
[TBL] [Abstract][Full Text] [Related]
3. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.
Deng X; Elkins JM; Zhang J; Yang Q; Erazo T; Gomez N; Choi HG; Wang J; Dzamko N; Lee JD; Sim T; Kim N; Alessi DR; Lizcano JM; Knapp S; Gray NS
Eur J Med Chem; 2013; 70():758-67. PubMed ID: 24239623
[TBL] [Abstract][Full Text] [Related]
4. Correction to "Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6
Ferguson FM; Liu Y; Harshbarger W; Huang L; Wang J; Deng X; Capuzzi SJ; Muratov EN; Tropsha A; Muthuswamy S; Westover KD; Gray NS
J Med Chem; 2020 Sep; 63(17):10088. PubMed ID: 32790356
[No Abstract] [Full Text] [Related]
5. Discovery of a selective inhibitor of doublecortin like kinase 1.
Ferguson FM; Nabet B; Raghavan S; Liu Y; Leggett AL; Kuljanin M; Kalekar RL; Yang A; He S; Wang J; Ng RWS; Sulahian R; Li L; Poulin EJ; Huang L; Koren J; Dieguez-Martinez N; Espinosa S; Zeng Z; Corona CR; Vasta JD; Ohi R; Sim T; Kim ND; Harshbarger W; Lizcano JM; Robers MB; Muthaswamy S; Lin CY; Look AT; Haigis KM; Mancias JD; Wolpin BM; Aguirre AJ; Hahn WC; Westover KD; Gray NS
Nat Chem Biol; 2020 Jun; 16(6):635-643. PubMed ID: 32251410
[TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of doublecortin-like kinase 1 inhibitors and their bioactivity evaluation.
Pan P; Ji D; Li Z; Meng X
J Enzyme Inhib Med Chem; 2024 Dec; 39(1):2287990. PubMed ID: 38062554
[TBL] [Abstract][Full Text] [Related]
7. Biochemical and Structural Insights into Doublecortin-like Kinase Domain 1.
Patel O; Dai W; Mentzel M; Griffin MD; Serindoux J; Gay Y; Fischer S; Sterle S; Kropp A; Burns CJ; Ernst M; Buchert M; Lucet IS
Structure; 2016 Sep; 24(9):1550-61. PubMed ID: 27545623
[TBL] [Abstract][Full Text] [Related]
8. Structural Basis of Inhibition of DCLK1 by Ruxolitinib.
Jang DM; Lim HJ; Hahn H; Lee Y; Kim HK; Kim HS
Int J Mol Sci; 2021 Aug; 22(16):. PubMed ID: 34445192
[TBL] [Abstract][Full Text] [Related]
9. Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation.
Egert-Schmidt AM; Dreher J; Dunkel U; Kohfeld S; Preu L; Weber H; Ehlert JE; Mutschler B; Totzke F; Schächtele C; Kubbutat MH; Baumann K; Kunick C
J Med Chem; 2010 Mar; 53(6):2433-42. PubMed ID: 20170163
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases.
McIver EG; Bryans J; Birchall K; Chugh J; Drake T; Lewis SJ; Osborne J; Smiljanic-Hurley E; Tsang W; Kamal A; Levy A; Newman M; Taylor D; Arthur JS; Clark K; Cohen P
Bioorg Med Chem Lett; 2012 Dec; 22(23):7169-73. PubMed ID: 23099093
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and biological evaluation of 2-anilino-4-substituted-7H-pyrrolopyrimidines as PDK1 inhibitors.
O'Brien NJ; Brzozowski M; Buskes MJ; Deady LW; Abbott BM
Bioorg Med Chem; 2014 Aug; 22(15):3879-86. PubMed ID: 25012568
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of novel 8,9-dihydro-5H-pyrimido[4,5-e][1,4]diazepin-7(6H)-ones.
Xiang J; Wen D; Xie H; Dang Q; Bai X
J Comb Chem; 2010 Jul; 12(4):503-9. PubMed ID: 20507170
[TBL] [Abstract][Full Text] [Related]
13. Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.
McClellan WJ; Dai Y; Abad-Zapatero C; Albert DH; Bouska JJ; Glaser KB; Magoc TJ; Marcotte PA; Osterling DJ; Stewart KD; Davidsen SK; Michaelides MR
Bioorg Med Chem Lett; 2011 Sep; 21(18):5620-4. PubMed ID: 21778056
[TBL] [Abstract][Full Text] [Related]
14. Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors.
Matsumaru T; Inai M; Ishigami K; Iwamatsu T; Maita H; Otsuguro S; Nomura T; Matsuda A; Ichikawa S; Sakaitani M; Shuto S; Maenaka K; Kan T
Bioorg Med Chem Lett; 2017 May; 27(10):2144-2147. PubMed ID: 28385506
[TBL] [Abstract][Full Text] [Related]
15. 2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
Argiriadi MA; Ericsson AM; Harris CM; Banach DL; Borhani DW; Calderwood DJ; Demers MD; Dimauro J; Dixon RW; Hardman J; Kwak S; Li B; Mankovich JA; Marcotte D; Mullen KD; Ni B; Pietras M; Sadhukhan R; Sousa S; Tomlinson MJ; Wang L; Xiang T; Talanian RV
Bioorg Med Chem Lett; 2010 Jan; 20(1):330-3. PubMed ID: 19919896
[TBL] [Abstract][Full Text] [Related]
16. Functional implication of Dclk1 and Dclk1-expressing cells in cancer.
Westphalen CB; Quante M; Wang TC
Small GTPases; 2017 Jul; 8(3):164-171. PubMed ID: 27458755
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors.
Zhao C; Tovar C; Yin X; Xu Q; Todorov IT; Vassilev LT; Chen L
Bioorg Med Chem Lett; 2009 Jan; 19(2):319-23. PubMed ID: 19071019
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.
Fu RG; You QD; Yang L; Wu WT; Jiang C; Xu XL
Bioorg Med Chem; 2010 Nov; 18(22):8035-43. PubMed ID: 20934346
[TBL] [Abstract][Full Text] [Related]
19. Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Li K; McGee LR; Fisher B; Sudom A; Liu J; Rubenstein SM; Anwer MK; Cushing TD; Shin Y; Ayres M; Lee F; Eksterowicz J; Faulder P; Waszkowycz B; Plotnikova O; Farrelly E; Xiao SH; Chen G; Wang Z
Bioorg Med Chem Lett; 2013 Mar; 23(5):1238-44. PubMed ID: 23374866
[TBL] [Abstract][Full Text] [Related]
20. Doublecortin-Like Kinase 1 (DCLK1) Regulates B Cell-Specific Moloney Murine Leukemia Virus Insertion Site 1 (Bmi-1) and is Associated with Metastasis and Prognosis in Pancreatic Cancer.
Li J; Wang Y; Ge J; Li W; Yin L; Zhao Z; Liu S; Qin H; Yang J; Wang L; Ni B; Liu Y; Wang H
Cell Physiol Biochem; 2018; 51(1):262-277. PubMed ID: 30453285
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]