BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

270 related articles for article (PubMed ID: 32531194)

  • 1. Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids.
    VanderWall KB; Huang KC; Pan Y; Lavekar SS; Fligor CM; Allsop AR; Lentsch KA; Dang P; Zhang C; Tseng HC; Cummins TR; Meyer JS
    Stem Cell Reports; 2020 Jul; 15(1):52-66. PubMed ID: 32531194
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells.
    Gomes C; VanderWall KB; Pan Y; Lu X; Lavekar SS; Huang KC; Fligor CM; Harkin J; Zhang C; Cummins TR; Meyer JS
    Stem Cell Reports; 2022 Jul; 17(7):1636-1649. PubMed ID: 35714595
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.
    Liu X; Wang Q; Shao Z; Zhang S; Hou M; Jiang M; Du M; Li J; Yuan H
    Hum Mol Genet; 2021 May; 30(11):1030-1044. PubMed ID: 33856034
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation.
    Hou M; Shao Z; Zhang S; Liu X; Fan P; Jiang M; Zhao Y; Xiao R; Yuan H
    Cell Death Dis; 2022 Apr; 13(4):362. PubMed ID: 35436991
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma.
    Sayyad Z; Vishwakarma S; Dave TV; Naik MN; Radha V; Kaur I; Swarup G
    Neurochem Int; 2021 Sep; 148():105075. PubMed ID: 34023378
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice.
    Chi ZL; Akahori M; Obazawa M; Minami M; Noda T; Nakaya N; Tomarev S; Kawase K; Yamamoto T; Noda S; Sasaoka M; Shimazaki A; Takada Y; Iwata T
    Hum Mol Genet; 2010 Jul; 19(13):2606-15. PubMed ID: 20388642
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Neuroprotective effects of bone marrow Sca-1
    Liu X; Hou M; Zhang S; Zhao Y; Wang Q; Jiang M; Du M; Shao Z; Yuan H
    Cell Death Dis; 2021 Jun; 12(6):613. PubMed ID: 34127652
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.
    Swarup G; Sayyad Z
    Front Immunol; 2018; 9():1287. PubMed ID: 29951055
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma.
    Huang KC; Gomes C; Shiga Y; Belforte N; VanderWall KB; Lavekar SS; Fligor CM; Harkin J; Di Polo A; Meyer JS
    bioRxiv; 2023 Jan; ():. PubMed ID: 36711831
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants.
    Chalasani ML; Radha V; Gupta V; Agarwal N; Balasubramanian D; Swarup G
    Invest Ophthalmol Vis Sci; 2007 Apr; 48(4):1607-14. PubMed ID: 17389490
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration.
    Ohlemacher SK; Sridhar A; Xiao Y; Hochstetler AE; Sarfarazi M; Cummins TR; Meyer JS
    Stem Cells; 2016 Jun; 34(6):1553-62. PubMed ID: 26996528
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.
    Minegishi Y; Iejima D; Kobayashi H; Chi ZL; Kawase K; Yamamoto T; Seki T; Yuasa S; Fukuda K; Iwata T
    Hum Mol Genet; 2013 Sep; 22(17):3559-67. PubMed ID: 23669351
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro.
    Zhang S; Shao Z; Liu X; Hou M; Cheng F; Lei D; Yuan H
    Cell Death Discov; 2021 Mar; 7(1):49. PubMed ID: 33723228
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effect of Timolol on Optineurin Aggregation in Transformed Induced Pluripotent Stem Cells Derived From Patient With Familial Glaucoma.
    Inagaki S; Kawase K; Funato M; Seki J; Kawase C; Ohuchi K; Kameyama T; Ando S; Sato A; Morozumi W; Nakamura S; Shimazawa M; Iejima D; Iwata T; Yamamoto T; Kaneko H; Hara H
    Invest Ophthalmol Vis Sci; 2018 May; 59(6):2293-2304. PubMed ID: 29847634
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Roles of Optineurin and Extracellular Vesicles in Glaucomatous Retinal Cell Loss.
    Duan CY; Fan WL; Chen F
    Curr Med Sci; 2023 Apr; 43(2):367-375. PubMed ID: 37059934
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.
    Medchalmi S; Tare P; Sayyad Z; Swarup G
    FEBS J; 2021 Aug; 288(15):4576-4595. PubMed ID: 33548116
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Significance of optineurin mutations in glaucoma and other diseases.
    Minegishi Y; Nakayama M; Iejima D; Kawase K; Iwata T
    Prog Retin Eye Res; 2016 Nov; 55():149-181. PubMed ID: 27693724
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Transgenic mice with overexpression of mutated human optineurin(E50K) in the retina.
    Meng Q; Xiao Z; Yuan H; Xue F; Zhu Y; Zhou X; Yang B; Sun J; Meng B; Sun X; Cheng F
    Mol Biol Rep; 2012 Feb; 39(2):1119-24. PubMed ID: 21681420
    [TBL] [Abstract][Full Text] [Related]  

  • 19. E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.
    Chalasani ML; Kumari A; Radha V; Swarup G
    PLoS One; 2014; 9(4):e95758. PubMed ID: 24752605
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Defects in autophagy caused by glaucoma-associated mutations in optineurin.
    Sirohi K; Swarup G
    Exp Eye Res; 2016 Mar; 144():54-63. PubMed ID: 26302410
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.