BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

123 related articles for article (PubMed ID: 32535330)

  • 61. Discovery of novel Thieno[2,3-d]pyrimidin-4-yl hydrazone-based cyclin-dependent kinase 4 inhibitors: synthesis, biological evaluation and structure-activity relationships.
    Horiuchi T; Takeda Y; Haginoya N; Miyazaki M; Nagata M; Kitagawa M; Akahane K; Uoto K
    Chem Pharm Bull (Tokyo); 2011; 59(8):991-1002. PubMed ID: 21804244
    [TBL] [Abstract][Full Text] [Related]  

  • 62. Autotaxin inhibition: challenges and progress toward novel anti-cancer agents.
    Parrill AL; Baker DL
    Anticancer Agents Med Chem; 2008 Dec; 8(8):917-23. PubMed ID: 19075574
    [TBL] [Abstract][Full Text] [Related]  

  • 63. Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part I.
    Das S; Harde RL; Shelke DE; Khairatkar-Joshi N; Bajpai M; Sapalya RS; Surve HV; Gudi GS; Pattem R; Behera DB; Jadhav SB; Thomas A
    Bioorg Med Chem Lett; 2014 May; 24(9):2073-8. PubMed ID: 24725435
    [TBL] [Abstract][Full Text] [Related]  

  • 64. Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach.
    Preti D; Romagnoli R; Rondanin R; Cacciari B; Hamel E; Balzarini J; Liekens S; Schols D; Estévez-Sarmiento F; Quintana J; Estévez F
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):1225-1238. PubMed ID: 30141353
    [TBL] [Abstract][Full Text] [Related]  

  • 65. Evaluation of sulfonate and sulfamate derivatives possessing benzofuran or benzothiophene nucleus as inhibitors of nucleotide pyrophosphatases/phosphodiesterases and anticancer agents.
    Anbar HS; El-Gamal R; Ullah S; Zaraei SO; Al-Rashida M; Zaib S; Pelletier J; Sévigny J; Iqbal J; El-Gamal MI
    Bioorg Chem; 2020 Nov; 104():104305. PubMed ID: 33017718
    [TBL] [Abstract][Full Text] [Related]  

  • 66. Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency.
    Salgado-Polo F; Fish A; Matsoukas MT; Heidebrecht T; Keune WJ; Perrakis A
    J Biol Chem; 2018 Sep; 293(37):14312-14327. PubMed ID: 30026231
    [TBL] [Abstract][Full Text] [Related]  

  • 67. Synthesis and biological evaluation of novel indole-pyrimidine hybrids bearing morpholine and thiomorpholine moieties.
    Diao PC; Li Q; Hu MJ; Ma YF; You WW; Hong KH; Zhao PL
    Eur J Med Chem; 2017 Jul; 134():110-118. PubMed ID: 28410492
    [TBL] [Abstract][Full Text] [Related]  

  • 68. PF-8380 and closely related analogs: synthesis and structure-activity relationship towards autotaxin inhibition and glioma cell viability.
    St-Cœur PD; Ferguson D; Morin P; Touaibia M
    Arch Pharm (Weinheim); 2013 Feb; 346(2):91-7. PubMed ID: 23300119
    [TBL] [Abstract][Full Text] [Related]  

  • 69. 1,2,3-triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: Their anti-proliferative & anti-inflammatory activity.
    Naaz F; Preeti Pallavi MC; Shafi S; Mulakayala N; Shahar Yar M; Sampath Kumar HM
    Bioorg Chem; 2018 Dec; 81():1-20. PubMed ID: 30081353
    [TBL] [Abstract][Full Text] [Related]  

  • 70. Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAF
    Al-Wahaibi LH; Gouda AM; Abou-Ghadir OF; Salem OIA; Ali AT; Farghaly HS; Abdelrahman MH; Trembleau L; Abdu-Allah HHM; Youssif BGM
    Bioorg Chem; 2020 Nov; 104():104260. PubMed ID: 32920363
    [TBL] [Abstract][Full Text] [Related]  

  • 71. From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
    Mostinski Y; Heynen GJJE; López-Alberca MP; Paul J; Miksche S; Radetzki S; Schaller D; Shanina E; Seyffarth C; Kolomeets Y; Ziebart N; de Schryver J; Oestreich S; Neuenschwander M; Roske Y; Heinemann U; Rademacher C; Volkamer A; von Kries JP; Birchmeier W; Nazaré M
    J Med Chem; 2020 Dec; 63(23):14780-14804. PubMed ID: 33210922
    [TBL] [Abstract][Full Text] [Related]  

  • 72. Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
    Quirit JG; Lavrenov SN; Poindexter K; Xu J; Kyauk C; Durkin KA; Aronchik I; Tomasiak T; Solomatin YA; Preobrazhenskaya MN; Firestone GL
    Biochem Pharmacol; 2017 Mar; 127():13-27. PubMed ID: 27979631
    [TBL] [Abstract][Full Text] [Related]  

  • 73. Anticancer profile of newly synthesized BRAF inhibitors possess 5-(pyrimidin-4-yl)imidazo[2,1-b]thiazole scaffold.
    Abdel-Maksoud MS; Ammar UM; Oh CH
    Bioorg Med Chem; 2019 May; 27(10):2041-2051. PubMed ID: 30955995
    [TBL] [Abstract][Full Text] [Related]  

  • 74. Design, synthesis and molecular modeling studies of new series of antitumor 1,2,4-triazines with potential c-Met kinase inhibitory activity.
    El-Wakil MH; Ashour HM; Saudi MN; Hassan AM; Labouta IM
    Bioorg Chem; 2018 Feb; 76():154-165. PubMed ID: 29175587
    [TBL] [Abstract][Full Text] [Related]  

  • 75. Synthesis of Tolmetin Hydrazide-Hydrazones and Discovery of a Potent Apoptosis Inducer in Colon Cancer Cells.
    Küçükgüzel ŞG; Koç D; Çıkla-Süzgün P; Özsavcı D; Bingöl-Özakpınar Ö; Mega-Tiber P; Orun O; Erzincan P; Sağ-Erdem S; Şahin F
    Arch Pharm (Weinheim); 2015 Oct; 348(10):730-42. PubMed ID: 26287512
    [TBL] [Abstract][Full Text] [Related]  

  • 76. Identifying Novel ATX Inhibitors via Combinatory Virtual Screening Using Crystallography-Derived Pharmacophore Modelling, Docking Study, and QSAR Analysis.
    Ren JX; Zhang RT; Zhang H
    Molecules; 2020 Mar; 25(5):. PubMed ID: 32131468
    [TBL] [Abstract][Full Text] [Related]  

  • 77. Pharmacophoric Site Identification and Inhibitor Design for Autotaxin.
    Lee MH; Lee DY; Balupuri A; Jeong JW; Kang NS
    Molecules; 2019 Aug; 24(15):. PubMed ID: 31374894
    [TBL] [Abstract][Full Text] [Related]  

  • 78. Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability.
    Chino A; Masuda N; Amano Y; Honbou K; Mihara T; Yamazaki M; Tomishima M
    Bioorg Med Chem; 2014 Jul; 22(13):3515-26. PubMed ID: 24837154
    [TBL] [Abstract][Full Text] [Related]  

  • 79. Synthesis and Biological Evaluation of Indole-2-carbohydrazide Derivatives as Anticancer Agents with Anti-angiogenic and Antiproliferative Activities.
    Zhang J; Liu T; Chen M; Liu F; Liu X; Zhang J; Lin J; Jin Y
    ChemMedChem; 2018 Jun; 13(12):1181-1192. PubMed ID: 29637713
    [TBL] [Abstract][Full Text] [Related]  

  • 80. Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5.
    Dan A; Shiyama T; Yamazaki K; Kusunose N; Fujita K; Sato H; Matsui K; Kitano M
    Bioorg Med Chem Lett; 2005 Sep; 15(18):4085-90. PubMed ID: 16005625
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.