389 related articles for article (PubMed ID: 32574549)
1. KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease.
Dayalan Naidu S; Dinkova-Kostova AT
Open Biol; 2020 Jun; 10(6):200105. PubMed ID: 32574549
[TBL] [Abstract][Full Text] [Related]
2. Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.
Dinkova-Kostova AT; Kostov RV; Canning P
Arch Biochem Biophys; 2017 Mar; 617():84-93. PubMed ID: 27497696
[TBL] [Abstract][Full Text] [Related]
3. Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis.
Dikovskaya D; Appleton PL; Bento-Pereira C; Dinkova-Kostova AT
Chem Res Toxicol; 2019 Mar; 32(3):500-512. PubMed ID: 30793592
[TBL] [Abstract][Full Text] [Related]
4. Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
McMahon M; Swift SR; Hayes JD
Toxicol Appl Pharmacol; 2018 Dec; 360():45-57. PubMed ID: 30261176
[TBL] [Abstract][Full Text] [Related]
5. NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation.
He X; Ma Q
Mol Pharmacol; 2009 Dec; 76(6):1265-78. PubMed ID: 19786557
[TBL] [Abstract][Full Text] [Related]
6. Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression.
Nezu M; Suzuki N; Yamamoto M
Am J Nephrol; 2017; 45(6):473-483. PubMed ID: 28502971
[TBL] [Abstract][Full Text] [Related]
7. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Kobayashi A; Kang MI; Okawa H; Ohtsuji M; Zenke Y; Chiba T; Igarashi K; Yamamoto M
Mol Cell Biol; 2004 Aug; 24(16):7130-9. PubMed ID: 15282312
[TBL] [Abstract][Full Text] [Related]
8. The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway.
Baird L; Yamamoto M
Mol Cell Biol; 2020 Jun; 40(13):. PubMed ID: 32284348
[TBL] [Abstract][Full Text] [Related]
9. Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
Baird L; Dinkova-Kostova AT
Biochem Biophys Res Commun; 2013 Mar; 433(1):58-65. PubMed ID: 23454126
[TBL] [Abstract][Full Text] [Related]
10. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
Uruno A; Motohashi H
Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
[TBL] [Abstract][Full Text] [Related]
11. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
Eggler AL; Small E; Hannink M; Mesecar AD
Biochem J; 2009 Jul; 422(1):171-80. PubMed ID: 19489739
[TBL] [Abstract][Full Text] [Related]
12. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Bresciani A; Missineo A; Gallo M; Cerretani M; Fezzardi P; Tomei L; Cicero DO; Altamura S; Santoprete A; Ingenito R; Bianchi E; Pacifici R; Dominguez C; Munoz-Sanjuan I; Harper S; Toledo-Sherman L; Park LC
Arch Biochem Biophys; 2017 Oct; 631():31-41. PubMed ID: 28801166
[TBL] [Abstract][Full Text] [Related]
13. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
Zhang DD; Lo SC; Sun Z; Habib GM; Lieberman MW; Hannink M
J Biol Chem; 2005 Aug; 280(34):30091-9. PubMed ID: 15983046
[TBL] [Abstract][Full Text] [Related]
14. Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.
Suzuki T; Yamamoto M
J Biol Chem; 2017 Oct; 292(41):16817-16824. PubMed ID: 28842501
[TBL] [Abstract][Full Text] [Related]
15. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
Villeneuve NF; Lau A; Zhang DD
Antioxid Redox Signal; 2010 Dec; 13(11):1699-712. PubMed ID: 20486766
[TBL] [Abstract][Full Text] [Related]
16. Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
Huerta C; Jiang X; Trevino I; Bender CF; Ferguson DA; Probst B; Swinger KK; Stoll VS; Thomas PJ; Dulubova I; Visnick M; Wigley WC
Biochim Biophys Acta; 2016 Nov; 1860(11 Pt A):2537-2552. PubMed ID: 27474998
[TBL] [Abstract][Full Text] [Related]
17. Structural and mechanistic insights into the Keap1-Nrf2 system as a route to drug discovery.
Madden SK; Itzhaki LS
Biochim Biophys Acta Proteins Proteom; 2020 Jul; 1868(7):140405. PubMed ID: 32120017
[TBL] [Abstract][Full Text] [Related]
18. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease.
Tebay LE; Robertson H; Durant ST; Vitale SR; Penning TM; Dinkova-Kostova AT; Hayes JD
Free Radic Biol Med; 2015 Nov; 88(Pt B):108-146. PubMed ID: 26122708
[TBL] [Abstract][Full Text] [Related]
19. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.
Dayalan Naidu S; Muramatsu A; Saito R; Asami S; Honda T; Hosoya T; Itoh K; Yamamoto M; Suzuki T; Dinkova-Kostova AT
Sci Rep; 2018 May; 8(1):8037. PubMed ID: 29795117
[TBL] [Abstract][Full Text] [Related]
20. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.
Bollong MJ; Lee G; Coukos JS; Yun H; Zambaldo C; Chang JW; Chin EN; Ahmad I; Chatterjee AK; Lairson LL; Schultz PG; Moellering RE
Nature; 2018 Oct; 562(7728):600-604. PubMed ID: 30323285
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
