These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 32581257)

  • 1. Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor.
    Tian QQ; Zhu YT; Diao XX; Zhang XL; Xu YC; Jiang XR; Shen JS; Wang Z; Zhong DF
    Acta Pharmacol Sin; 2021 Mar; 42(3):482-490. PubMed ID: 32581257
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of TPN729 metabolites in humans using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
    Zhu Y; Li L; Deng P; Chen X; Zhong D
    J Pharm Biomed Anal; 2016 Jan; 117():217-26. PubMed ID: 26366939
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
    Pan L; Guo S; Chen X; Jiang X; Shen J; Diao X; Wang Z; Zhong D
    J Pharm Biomed Anal; 2019 Aug; 172():302-310. PubMed ID: 31079024
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Absorption, distribution, metabolism, and excretion of [
    Cheng H; Yu J; Yang C; Zhang N; Fan Z; Zhang X; Wang J; Wang Z; Zhong DF; He JX; Yan S; Diao X
    Xenobiotica; 2022 Jan; 52(1):79-90. PubMed ID: 35038952
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolism of delavirdine, a human immunodeficiency virus type-1 reverse transcriptase inhibitor, by microsomal cytochrome P450 in humans, rats, and other species: probable involvement of CYP2D6 and CYP3A.
    Voorman RL; Maio SM; Hauer MJ; Sanders PE; Payne NA; Ackland MJ
    Drug Metab Dispos; 1998 Jul; 26(7):631-9. PubMed ID: 9660845
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vitro studies on the oxidative metabolism of 20(s)-ginsenoside Rh2 in human, monkey, dog, rat, and mouse liver microsomes, and human liver s9.
    Li L; Chen X; Zhou J; Zhong D
    Drug Metab Dispos; 2012 Oct; 40(10):2041-53. PubMed ID: 22829543
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolism of aildenafil in vivo in rats and in vitro in mouse, rat, dog, and human liver microsomes.
    Li Y; Wu L; Gu Y; Si D; Liu C
    Drug Test Anal; 2014 Jun; 6(6):552-62. PubMed ID: 24311535
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Simultaneous determination of TPN729 and its five metabolites in human plasma and urine by liquid chromatography coupled to tandem mass spectrometry.
    Liu Y; Shao S; Song H; Yao X; Liu J; Liu H; Song L; Jiang J; Liu D; Hu P
    J Pharm Biomed Anal; 2018 Mar; 151():91-105. PubMed ID: 29310052
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study.
    Shin KH; Kim BH; Kim TE; Kim JW; Yi S; Yoon SH; Cho JY; Shin SG; Jang IJ; Yu KS
    Clin Ther; 2009 Dec; 31(12):3009-20. PubMed ID: 20110038
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation.
    Takahiro R; Nakamura S; Kohno H; Yoshimura N; Nakamura T; Ozawa S; Hirono K; Ichida F; Taguchi M
    Biol Pharm Bull; 2015; 38(1):58-65. PubMed ID: 25744459
    [TBL] [Abstract][Full Text] [Related]  

  • 11. In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.
    Xu L; Woodward C; Khan S; Prakash C
    Drug Metab Dispos; 2012 Apr; 40(4):680-93. PubMed ID: 22217465
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys.
    Zhang H; Zhang D; Li W; Yao M; D'Arienzo C; Li YX; Ewing WR; Gu Z; Zhu Y; Murugesan N; Shyu WC; Humphreys WG
    Drug Metab Dispos; 2007 May; 35(5):795-805. PubMed ID: 17303626
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In vitro liver metabolism of aclidinium bromide in preclinical animal species and humans: identification of the human enzymes involved in its oxidative metabolism.
    Albertí JJ; Sentellas S; Salvà M
    Biochem Pharmacol; 2011 Mar; 81(6):761-76. PubMed ID: 21184745
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor.
    Obach RS; Margolis JM; Logman MJ
    Drug Metab Pharmacokinet; 2007 Oct; 22(5):336-49. PubMed ID: 17965517
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Preclinical pharmacokinetics of TPN729MA, a novel PDE5 inhibitor, and prediction of its human pharmacokinetics using a PBPK model.
    Gao ZW; Zhu YT; Yu MM; Zan B; Liu J; Zhang YF; Chen XY; Li XN; Zhong DF
    Acta Pharmacol Sin; 2015 Dec; 36(12):1528-36. PubMed ID: 26592518
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro.
    Bakken GV; Molden E; Knutsen K; Lunder N; Hermann M
    Drug Metab Dispos; 2012 Sep; 40(9):1778-84. PubMed ID: 22688609
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
    Niwa T; Shiraga T; Mitani Y; Terakawa M; Tokuma Y; Kagayama A
    Drug Metab Dispos; 2000 Sep; 28(9):1128-34. PubMed ID: 10950860
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A novel biotransformation of alkyl aminopyrrolidine to aminopiperidine ring by human CYP3A.
    Chen Y; Skiles GL; Shou M; Hickman D; Hsieh F
    Drug Metab Dispos; 2011 Sep; 39(9):1668-73. PubMed ID: 21673127
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification.
    Kumar GN; Jayanti V; Lee RD; Whittern DN; Uchic J; Thomas S; Johnson P; Grabowski B; Sham H; Betebenner D; Kempf DJ; Denissen JF
    Drug Metab Dispos; 1999 Jan; 27(1):86-91. PubMed ID: 9884314
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.