BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

123 related articles for article (PubMed ID: 32588086)

  • 1. Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?
    Novotná E; Morell A; Büküm N; Hofman J; Danielisová P; Wsól V
    Arch Toxicol; 2020 Sep; 94(9):3059-3068. PubMed ID: 32588086
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Selective inhibition of aldo-keto reductase 1C3: a novel mechanism involved in midostaurin and daunorubicin synergism.
    Morell A; Novotná E; Milan J; Danielisová P; Büküm N; Wsól V
    Arch Toxicol; 2021 Jan; 95(1):67-78. PubMed ID: 33025066
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Isocitrate dehydrogenase 2 inhibitor enasidenib synergizes daunorubicin cytotoxicity by targeting aldo-keto reductase 1C3 and ATP-binding cassette transporters.
    Morell A; Budagaga Y; Vagiannis D; Zhang Y; Laštovičková L; Novotná E; Haddad A; Haddad M; Portillo R; Hofman J; Wsól V
    Arch Toxicol; 2022 Dec; 96(12):3265-3277. PubMed ID: 35972551
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile.
    Novotná E; Büküm N; Hofman J; Flaxová M; Kouklíková E; Louvarová D; Wsól V
    Arch Toxicol; 2018 Sep; 92(9):2845-2857. PubMed ID: 29992508
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In Silico and In Vitro Assessment of Carbonyl Reductase 1 Inhibition Using ASP9521-A Potent Aldo-Keto Reductase 1C3 Inhibitor with the Potential to Support Anticancer Therapy Using Anthracycline Antibiotics.
    Jamrozik M; Piska K; Bucki A; Koczurkiewicz-Adamczyk P; Sapa M; Władyka B; Pękala E; Kołaczkowski M
    Molecules; 2023 Apr; 28(9):. PubMed ID: 37175180
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3.
    Hofman J; Malcekova B; Skarka A; Novotna E; Wsol V
    Toxicol Appl Pharmacol; 2014 Aug; 278(3):238-48. PubMed ID: 24832494
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3.
    Bukum N; Novotna E; Morell A; Hofman J; Wsol V
    Chem Biol Interact; 2019 Apr; 302():101-107. PubMed ID: 30703376
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of human anthracycline reductases by emodin - A possible remedy for anthracycline resistance.
    Hintzpeter J; Seliger JM; Hofman J; Martin HJ; Wsol V; Maser E
    Toxicol Appl Pharmacol; 2016 Feb; 293():21-9. PubMed ID: 26773812
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia.
    Verma K; Zang T; Penning TM; Trippier PC
    J Med Chem; 2019 Apr; 62(7):3590-3616. PubMed ID: 30836001
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment.
    Novotná E; Büküm N; Hofman J; Flaxová M; Kouklíková E; Louvarová D; Wsól V
    Biochem Pharmacol; 2018 Oct; 156():22-31. PubMed ID: 30077642
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Bruton's Tyrosine Kinase Inhibitors Ibrutinib and Acalabrutinib Counteract Anthracycline Resistance in Cancer Cells Expressing AKR1C3.
    Morell A; Čermáková L; Novotná E; Laštovičková L; Haddad M; Haddad A; Portillo R; Wsól V
    Cancers (Basel); 2020 Dec; 12(12):. PubMed ID: 33322571
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin.
    Sheng X; Parmentier JH; Tucci J; Pei H; Cortez-Toledo O; Dieli-Conwright CM; Oberley MJ; Neely M; Orgel E; Louie SG; Mittelman SD
    Mol Cancer Res; 2017 Dec; 15(12):1704-1713. PubMed ID: 29117945
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of AKR1B10-mediated metabolism of daunorubicin as a novel off-target effect for the Bcr-Abl tyrosine kinase inhibitor dasatinib.
    Büküm N; Novotná E; Morell A; Želazková J; Laštovičková L; Čermáková L; Portillo R; Solich P; Wsól V
    Biochem Pharmacol; 2021 Oct; 192():114710. PubMed ID: 34339712
    [TBL] [Abstract][Full Text] [Related]  

  • 14. In vitro evaluation of the reductive carbonyl idarubicin metabolism to evaluate inhibitors of the formation of cardiotoxic idarubicinol via carbonyl and aldo-keto reductases.
    Bajraktari-Sylejmani G; Oster JS; Burhenne J; Haefeli WE; Sauter M; Weiss J
    Arch Toxicol; 2024 Mar; 98(3):807-820. PubMed ID: 38175295
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Metabolic carbonyl reduction of anthracyclines - role in cardiotoxicity and cancer resistance. Reducing enzymes as putative targets for novel cardioprotective and chemosensitizing agents.
    Piska K; Koczurkiewicz P; Bucki A; Wójcik-Pszczoła K; Kołaczkowski M; Pękala E
    Invest New Drugs; 2017 Jun; 35(3):375-385. PubMed ID: 28283780
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interindividual variability in the cardiac expression of anthracycline reductases in donors with and without Down syndrome.
    Quiñones-Lombraña A; Ferguson D; Hageman Blair R; Kalabus JL; Redzematovic A; Blanco JG
    Pharm Res; 2014 Jul; 31(7):1644-55. PubMed ID: 24562808
    [TBL] [Abstract][Full Text] [Related]  

  • 17. AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13 ketonic group.
    Zhong L; Shen H; Huang C; Jing H; Cao D
    Toxicol Appl Pharmacol; 2011 Aug; 255(1):40-7. PubMed ID: 21640744
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3.
    Tavares TS; Hofman J; Lekešová A; Želazková J; Wsól V
    Cancers (Basel); 2020 Oct; 12(11):. PubMed ID: 33114555
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Characterization of the Canine Anthracycline-Metabolizing Enzyme Carbonyl Reductase 1 (cbr1) and the Functional Isoform cbr1 V218.
    Ferguson DC; Cheng Q; Blanco JG
    Drug Metab Dispos; 2015 Jul; 43(7):922-7. PubMed ID: 25918240
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters.
    Sorf A; Novotna E; Hofman J; Morell A; Staud F; Wsol V; Ceckova M
    Biochem Pharmacol; 2019 May; 163():290-298. PubMed ID: 30826329
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.