BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

122 related articles for article (PubMed ID: 32591543)

  • 1. An alkaloid initiates phosphodiesterase 3A-schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity.
    Ai Y; He H; Chen P; Yan B; Zhang W; Ding Z; Li D; Chen J; Ma Y; Cao Y; Zhu J; Li J; Ou J; Du S; Wang X; Ma J; Gao S; Qi X
    Nat Commun; 2020 Jun; 11(1):3236. PubMed ID: 32591543
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells.
    Chen J; Liu N; Huang Y; Wang Y; Sun Y; Wu Q; Li D; Gao S; Wang HW; Huang N; Qi X; Wang X
    Nat Commun; 2021 Oct; 12(1):6204. PubMed ID: 34707099
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death.
    Yan B; Ding Z; Zhang W; Cai G; Han H; Ma Y; Cao Y; Wang J; Chen S; Ai Y
    Cell Chem Biol; 2022 Jun; 29(6):958-969.e5. PubMed ID: 35104454
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
    Wu X; Schnitzler GR; Gao GF; Diamond B; Baker AR; Kaplan B; Williamson K; Westlake L; Lorrey S; Lewis TA; Garvie CW; Lange M; Hayat S; Seidel H; Doench J; Cherniack AD; Kopitz C; Meyerson M; Greulich H
    J Biol Chem; 2020 Mar; 295(11):3431-3446. PubMed ID: 32005668
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).
    Vandenberghe P; Hagué P; Hockman SC; Manganiello VC; Demetter P; Erneux C; Vanderwinden JM
    Oncotarget; 2017 Jun; 8(25):41026-41043. PubMed ID: 28454120
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphodiesterase 3A Represents a Therapeutic Target that Drives Stem Cell-like Property and Metastasis in Breast Cancer.
    Hao N; Shen W; Du R; Jiang S; Zhu J; Chen Y; Huang C; Shi Y; Xiang R; Luo Y
    Mol Cancer Ther; 2020 Mar; 19(3):868-881. PubMed ID: 31871268
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
    de Waal L; Lewis TA; Rees MG; Tsherniak A; Wu X; Choi PS; Gechijian L; Hartigan C; Faloon PW; Hickey MJ; Tolliday N; Carr SA; Clemons PA; Munoz B; Wagner BK; Shamji AF; Koehler AN; Schenone M; Burgin AB; Schreiber SL; Greulich H; Meyerson M
    Nat Chem Biol; 2016 Feb; 12(2):102-8. PubMed ID: 26656089
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
    Garvie CW; Wu X; Papanastasiou M; Lee S; Fuller J; Schnitzler GR; Horner SW; Baker A; Zhang T; Mullahoo JP; Westlake L; Hoyt SH; Toetzl M; Ranaghan MJ; de Waal L; McGaunn J; Kaplan B; Piccioni F; Yang X; Lange M; Tersteegen A; Raymond D; Lewis TA; Carr SA; Cherniack AD; Lemke CT; Meyerson M; Greulich H
    Nat Commun; 2021 Jul; 12(1):4375. PubMed ID: 34272366
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions.
    Coenen DM; Heinzmann ACA; Oggero S; Albers HJ; Nagy M; Hagué P; Kuijpers MJE; Vanderwinden JM; van der Meer AD; Perretti M; Koenen RR; Cosemans JMEM
    Cells; 2021 Aug; 10(8):. PubMed ID: 34440764
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting tumor cells based on Phosphodiesterase 3A expression.
    Nazir M; Senkowski W; Nyberg F; Blom K; Edqvist PH; Jarvius M; Andersson C; Gustafsson MG; Nygren P; Larsson R; Fryknäs M
    Exp Cell Res; 2017 Dec; 361(2):308-315. PubMed ID: 29107068
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover.
    Li D; Chen J; Ai Y; Gu X; Li L; Che D; Jiang Z; Li L; Chen S; Huang H; Wang J; Cai T; Cao Y; Qi X; Wang X
    Mol Cell; 2019 Sep; 75(6):1103-1116.e9. PubMed ID: 31420216
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages.
    Sumbria RK; Vasilevko V; Grigoryan MM; Paganini-Hill A; Kim R; Cribbs DH; Fisher MJ
    J Neuroinflammation; 2017 Jun; 14(1):114. PubMed ID: 28583195
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PDE3A inhibitor anagrelide activates death signaling pathway genes and synergizes with cell death-inducing cytokines to selectively inhibit cancer cell growth.
    An R; Liu J; He J; Wang F; Zhang Q; Yu Q
    Am J Cancer Res; 2019; 9(9):1905-1921. PubMed ID: 31598394
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The synthesis and biological evaluation of nucleobases/tetrazole hybrid compounds: A new class of phosphodiesterase type 3 (PDE3) inhibitors.
    Shekouhy M; Karimian S; Moaddeli A; Faghih Z; Delshad Y; Khalafi-Nezhad A
    Bioorg Med Chem; 2020 Jun; 28(12):115540. PubMed ID: 32503691
    [TBL] [Abstract][Full Text] [Related]  

  • 15. In vitro effects of cilostazol, a phosphodiesterase 3A inhibitor, on mouse oocyte maturation and morphology.
    Taiyeb AM; Dees WL; Ridha-Albarzanchi MT; Sayes CM; Kraemer DC
    Clin Exp Pharmacol Physiol; 2014 Feb; 41(2):147-53. PubMed ID: 24341287
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop.
    Yan C; Ding B; Shishido T; Woo CH; Itoh S; Jeon KI; Liu W; Xu H; McClain C; Molina CA; Blaxall BC; Abe J
    Circ Res; 2007 Mar; 100(4):510-9. PubMed ID: 17272811
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of interaction sites of cyclic nucleotide phosphodiesterase type 3A with milrinone and cilostazol using molecular modeling and site-directed mutagenesis.
    Zhang W; Ke H; Colman RW
    Mol Pharmacol; 2002 Sep; 62(3):514-20. PubMed ID: 12181427
    [TBL] [Abstract][Full Text] [Related]  

  • 18. cUMP hydrolysis by PDE3A.
    Berrisch S; Ostermeyer J; Kaever V; Kälble S; Hilfiker-Kleiner D; Seifert R; Schneider EH
    Naunyn Schmiedebergs Arch Pharmacol; 2017 Mar; 390(3):269-280. PubMed ID: 27975297
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2.
    Ahmad F; Shen W; Vandeput F; Szabo-Fresnais N; Krall J; Degerman E; Goetz F; Klussmann E; Movsesian M; Manganiello V
    J Biol Chem; 2015 Mar; 290(11):6763-76. PubMed ID: 25593322
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Velcrin-induced selective cleavage of tRNA
    Lee S; Hoyt S; Wu X; Garvie C; McGaunn J; Shekhar M; Tötzl M; Rees MG; Cherniack AD; Meyerson M; Greulich H
    Nat Chem Biol; 2023 Mar; 19(3):301-310. PubMed ID: 36302897
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.