214 related articles for article (PubMed ID: 32601986)
1. The mTORC1 inhibitor rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory.
MacCallum PE; Blundell J
Psychopharmacology (Berl); 2020 Sep; 237(9):2795-2808. PubMed ID: 32601986
[TBL] [Abstract][Full Text] [Related]
2. Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.
Huynh TN; Santini E; Klann E
J Neurosci; 2014 Jul; 34(27):9034-9. PubMed ID: 24990923
[TBL] [Abstract][Full Text] [Related]
3. mTORC1-S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice.
Sun J; Liu Y; Tran J; O'Neal P; Baudry M; Bi X
Cell Mol Life Sci; 2016 Nov; 73(22):4303-4314. PubMed ID: 27173058
[TBL] [Abstract][Full Text] [Related]
4. Dual mTORC1/2 inhibitor AZD2014 diminishes myeloid-derived suppressor cells accumulation in ovarian cancer and delays tumor growth.
Pi R; Yang Y; Hu X; Li H; Shi H; Liu Y; Wang X; Tong A; Lu T; Wei Y; Zhao X; Wei X
Cancer Lett; 2021 Dec; 523():72-81. PubMed ID: 34560229
[TBL] [Abstract][Full Text] [Related]
5. Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection.
Fantus D; Dai H; Ono Y; Watson A; Yokota S; Mohib K; Yoshida O; Ross MA; Watkins SC; Ramaswami B; Valusjkikh A; Rothstein DM; Thomson AW
Transplantation; 2017 Dec; 101(12):2830-2840. PubMed ID: 28885497
[TBL] [Abstract][Full Text] [Related]
6. Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.
Kakiuchi Y; Yurube T; Kakutani K; Takada T; Ito M; Takeoka Y; Kanda Y; Miyazaki S; Kuroda R; Nishida K
Osteoarthritis Cartilage; 2019 Jun; 27(6):965-976. PubMed ID: 30716534
[TBL] [Abstract][Full Text] [Related]
7. Potent antitumour of the mTORC1/2 dual inhibitor AZD2014 in docetaxel-sensitive and docetaxel-resistant castration-resistant prostate cancer cells.
Li S; Sheng J; Liu Z; Fan Y; Zhang C; Lv T; Hu S; Jin J; Yu W; Song Y
J Cell Mol Med; 2021 Mar; 25(5):2436-2449. PubMed ID: 33507584
[TBL] [Abstract][Full Text] [Related]
8. Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory.
Huynh TN; Santini E; Mojica E; Fink AE; Hall BS; Fetcho RN; Grosenick L; Deisseroth K; LeDoux JE; Liston C; Klann E
Mol Psychiatry; 2018 Jun; 23(6):1394-1401. PubMed ID: 28461701
[TBL] [Abstract][Full Text] [Related]
9. Systemic inhibition of mTOR kinase via rapamycin disrupts consolidation and reconsolidation of auditory fear memory.
Mac Callum PE; Hebert M; Adamec RE; Blundell J
Neurobiol Learn Mem; 2014 Jul; 112():176-85. PubMed ID: 24012802
[TBL] [Abstract][Full Text] [Related]
10. AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules.
Guichard SM; Curwen J; Bihani T; D'Cruz CM; Yates JW; Grondine M; Howard Z; Davies BR; Bigley G; Klinowska T; Pike KG; Pass M; Chresta CM; Polanska UM; McEwen R; Delpuech O; Green S; Cosulich SC
Mol Cancer Ther; 2015 Nov; 14(11):2508-18. PubMed ID: 26358751
[TBL] [Abstract][Full Text] [Related]
11. Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation.
Blundell J; Kouser M; Powell CM
Neurobiol Learn Mem; 2008 Jul; 90(1):28-35. PubMed ID: 18316213
[TBL] [Abstract][Full Text] [Related]
12. mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination.
Khlaifia A; Honoré E; Artinian J; Laplante I; Lacaille JC
Mol Brain; 2022 Jun; 15(1):56. PubMed ID: 35715811
[TBL] [Abstract][Full Text] [Related]
13. Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus.
Gafford GM; Parsons RG; Helmstetter FJ
Neuroscience; 2011 May; 182():98-104. PubMed ID: 21439355
[TBL] [Abstract][Full Text] [Related]
14. The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells.
Kahn J; Hayman TJ; Jamal M; Rath BH; Kramp T; Camphausen K; Tofilon PJ
Neuro Oncol; 2014 Jan; 16(1):29-37. PubMed ID: 24311635
[TBL] [Abstract][Full Text] [Related]
15. Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors.
Melick CH; Jewell JL
Biochem J; 2020 May; 477(10):1847-1863. PubMed ID: 32347294
[TBL] [Abstract][Full Text] [Related]
16. Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with enhanced β-TrCP degradation.
Deng L; Qian G; Zhang S; Zheng H; Fan S; Lesinski GB; Owonikoko TK; Ramalingam SS; Sun SY
Oncogene; 2019 Aug; 38(35):6270-6282. PubMed ID: 31316145
[TBL] [Abstract][Full Text] [Related]
17. mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV.
Yang JY; Madrakhimov SB; Ahn DH; Chang HS; Jung SJ; Nah SK; Park HY; Park TK
Cell Commun Signal; 2019 Jun; 17(1):64. PubMed ID: 31200728
[TBL] [Abstract][Full Text] [Related]
18. Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice.
Haji N; Riebe I; Aguilar-Valles A; Artinian J; Laplante I; Lacaille JC
Mol Autism; 2020 May; 11(1):29. PubMed ID: 32375878
[TBL] [Abstract][Full Text] [Related]
19. Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition.
Kim ST; Kim SY; Klempner SJ; Yoon J; Kim N; Ahn S; Bang H; Kim KM; Park W; Park SH; Park JO; Park YS; Lim HY; Lee SH; Park K; Kang WK; Lee J
Ann Oncol; 2017 Mar; 28(3):547-554. PubMed ID: 28028034
[TBL] [Abstract][Full Text] [Related]
20. Investigation of the novel mTOR inhibitor AZD2014 in neuronal ischemia.
Hadley G; Beard DJ; Alexopoulou Z; Sutherland BA; Buchan AM
Neurosci Lett; 2019 Jul; 706():223-230. PubMed ID: 31100427
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
