367 related articles for article (PubMed ID: 32613609)
21. AD-linked R47H-
Sayed FA; Kodama L; Fan L; Carling GK; Udeochu JC; Le D; Li Q; Zhou L; Wong MY; Horowitz R; Ye P; Mathys H; Wang M; Niu X; Mazutis L; Jiang X; Wang X; Gao F; Brendel M; Telpoukhovskaia M; Tracy TE; Frost G; Zhou Y; Li Y; Qiu Y; Cheng Z; Yu G; Hardy J; Coppola G; Wang F; DeTure MA; Zhang B; Xie L; Trajnowski JQ; Lee VMY; Gong S; Sinha SC; Dickson DW; Luo W; Gan L
Sci Transl Med; 2021 Dec; 13(622):eabe3947. PubMed ID: 34851693
[TBL] [Abstract][Full Text] [Related]
22. Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
Belsare KD; Wu H; Mondal D; Bond A; Castillo E; Jin J; Jo H; Roush AE; Pilla KB; Sali A; Condello C; DeGrado WF
Proc Natl Acad Sci U S A; 2022 Feb; 119(5):. PubMed ID: 35082148
[TBL] [Abstract][Full Text] [Related]
23. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.
Zheng H; Jia L; Liu CC; Rong Z; Zhong L; Yang L; Chen XF; Fryer JD; Wang X; Zhang YW; Xu H; Bu G
J Neurosci; 2017 Feb; 37(7):1772-1784. PubMed ID: 28077724
[TBL] [Abstract][Full Text] [Related]
24. Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer's disease.
Toomey CE; Heywood W; Benson BC; Packham G; Mills K; Lashley T
Brain Pathol; 2020 Jul; 30(4):794-810. PubMed ID: 32267026
[TBL] [Abstract][Full Text] [Related]
25. R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.
Korvatska O; Leverenz JB; Jayadev S; McMillan P; Kurtz I; Guo X; Rumbaugh M; Matsushita M; Girirajan S; Dorschner MO; Kiianitsa K; Yu CE; Brkanac Z; Garden GA; Raskind WH; Bird TD
JAMA Neurol; 2015 Aug; 72(8):920-7. PubMed ID: 26076170
[TBL] [Abstract][Full Text] [Related]
26. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
Gratuze M; Leyns CE; Sauerbeck AD; St-Pierre MK; Xiong M; Kim N; Serrano JR; Tremblay MÈ; Kummer TT; Colonna M; Ulrich JD; Holtzman DM
J Clin Invest; 2020 Sep; 130(9):4954-4968. PubMed ID: 32544086
[TBL] [Abstract][Full Text] [Related]
27. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Zhong L; Xu Y; Zhuo R; Wang T; Wang K; Huang R; Wang D; Gao Y; Zhu Y; Sheng X; Chen K; Wang N; Zhu L; Can D; Marten Y; Shinohara M; Liu CC; Du D; Sun H; Wen L; Xu H; Bu G; Chen XF
Nat Commun; 2019 Mar; 10(1):1365. PubMed ID: 30911003
[TBL] [Abstract][Full Text] [Related]
28. The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Cheng-Hathaway PJ; Reed-Geaghan EG; Jay TR; Casali BT; Bemiller SM; Puntambekar SS; von Saucken VE; Williams RY; Karlo JC; Moutinho M; Xu G; Ransohoff RM; Lamb BT; Landreth GE
Mol Neurodegener; 2018 Jun; 13(1):29. PubMed ID: 29859094
[TBL] [Abstract][Full Text] [Related]
29. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
Piers TM; Cosker K; Mallach A; Johnson GT; Guerreiro R; Hardy J; Pocock JM
FASEB J; 2020 Feb; 34(2):2436-2450. PubMed ID: 31907987
[TBL] [Abstract][Full Text] [Related]
30. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Xiang X; Piers TM; Wefers B; Zhu K; Mallach A; Brunner B; Kleinberger G; Song W; Colonna M; Herms J; Wurst W; Pocock JM; Haass C
Mol Neurodegener; 2018 Sep; 13(1):49. PubMed ID: 30185230
[TBL] [Abstract][Full Text] [Related]
31. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease.
Jiang T; Tan L; Zhu XC; Zhang QQ; Cao L; Tan MS; Gu LZ; Wang HF; Ding ZZ; Zhang YD; Yu JT
Neuropsychopharmacology; 2014 Dec; 39(13):2949-62. PubMed ID: 25047746
[TBL] [Abstract][Full Text] [Related]
32. TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2
Ren S; Breuillaud L; Yao W; Yin T; Norris KA; Zehntner SP; D'Adamio L
J Biol Chem; 2021; 296():100089. PubMed ID: 33434745
[TBL] [Abstract][Full Text] [Related]
33. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Boza-Serrano A; Ruiz R; Sanchez-Varo R; García-Revilla J; Yang Y; Jimenez-Ferrer I; Paulus A; Wennström M; Vilalta A; Allendorf D; Davila JC; Stegmayr J; Jiménez S; Roca-Ceballos MA; Navarro-Garrido V; Swanberg M; Hsieh CL; Real LM; Englund E; Linse S; Leffler H; Nilsson UJ; Brown GC; Gutierrez A; Vitorica J; Venero JL; Deierborg T
Acta Neuropathol; 2019 Aug; 138(2):251-273. PubMed ID: 31006066
[TBL] [Abstract][Full Text] [Related]
34. TREM2, Microglia, and Neurodegenerative Diseases.
Yeh FL; Hansen DV; Sheng M
Trends Mol Med; 2017 Jun; 23(6):512-533. PubMed ID: 28442216
[TBL] [Abstract][Full Text] [Related]
35. Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge.
Cousins O; Schubert JJ; Chandra A; Veronese M; Valkimadi P; Creese B; Khan Z; Arathimos R; Hampshire A; Rosenzweig I; Ballard C; Corbett A; Aasland D; Velayudhan L; O'Neill M; Collier D; Awais R; Sander K; Årstad E; Howes O; Turkheimer F; Hodges A
J Neuroinflammation; 2023 Nov; 20(1):272. PubMed ID: 37990275
[TBL] [Abstract][Full Text] [Related]
36. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.
Griciuc A; Patel S; Federico AN; Choi SH; Innes BJ; Oram MK; Cereghetti G; McGinty D; Anselmo A; Sadreyev RI; Hickman SE; El Khoury J; Colonna M; Tanzi RE
Neuron; 2019 Sep; 103(5):820-835.e7. PubMed ID: 31301936
[TBL] [Abstract][Full Text] [Related]
37. Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer's Risk Variant.
Tambini MD; D'Adamio L
Sci Rep; 2020 Mar; 10(1):4122. PubMed ID: 32139718
[TBL] [Abstract][Full Text] [Related]
38. BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice.
Lee CYD; De La Rocha AJ; Inouye K; Langfelder P; Daggett A; Gu X; Jiang LL; Pamonag Z; Vaca RG; Richman J; Kawaguchi R; Gao F; Xu H; Yang XW
bioRxiv; 2023 Aug; ():. PubMed ID: 37577582
[TBL] [Abstract][Full Text] [Related]
39. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease.
Basha SC; Ramaiah MJ; Kosagisharaf JR
J Alzheimers Dis; 2023; 94(s1):S319-S333. PubMed ID: 36683512
[TBL] [Abstract][Full Text] [Related]
40. SHIP inhibition mediates select TREM2-induced microglial functions.
Ramakrishnan GS; Berry WL; Pacherille A; Kerr WG; Chisholm JD; Pedicone C; Humphrey MB
Mol Immunol; 2024 Jun; 170():35-45. PubMed ID: 38613944
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]