These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

217 related articles for article (PubMed ID: 32618019)

  • 1. Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis.
    Wang W; Yang X; Chen Y; Ye X; Jiang K; Xiong A; Yang L; Wang Z
    J Appl Toxicol; 2020 Nov; 40(11):1534-1544. PubMed ID: 32618019
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice.
    Yang X; Wang H; Ni HM; Xiong A; Wang Z; Sesaki H; Ding WX; Yang L
    Redox Biol; 2017 Aug; 12():264-273. PubMed ID: 28282614
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Exposure to Gynura japonica (Thunb.) Juel plants induces hepatoxicity in rats and Buffalo rat liver cells.
    Wen C; Zhou T; Chang Y; Wei Y; Zhang H; Yang Z
    J Ethnopharmacol; 2024 Dec; 335():118692. PubMed ID: 39151710
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hepatotoxicity of Pyrrolizidine Alkaloid Compound Intermedine: Comparison with Other Pyrrolizidine Alkaloids and Its Toxicological Mechanism.
    Wang Z; Han H; Wang C; Zheng Q; Chen H; Zhang X; Hou R
    Toxins (Basel); 2021 Nov; 13(12):. PubMed ID: 34941687
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The long persistence of pyrrolizidine alkaloid-derived pyrrole-protein adducts in vivo: Kinetic study following multiple exposures of a pyrrolizidine alkaloid containing extract of Gynura japonica.
    Chen Y; Xiong F; Wang W; Jiang K; Ye X; Deng G; Wang C; Yang L; Xiong A; Wang Z
    Toxicol Lett; 2020 May; 323():41-47. PubMed ID: 31982501
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Gynura Rhizoma containing pyrrolizidine alkaloids induces the hepatic sinusoidal obstruction syndrome in mice via upregulating fibrosis-related factors.
    Zhang F; Zhou Y; Yang X; Xiong AZ; Wang ZT; Yang L
    Acta Pharmacol Sin; 2019 Jun; 40(6):781-789. PubMed ID: 30367152
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
    Xie Y; McGill MR; Du K; Dorko K; Kumer SC; Schmitt TM; Ding WX; Jaeschke H
    Toxicol Appl Pharmacol; 2015 Dec; 289(2):213-22. PubMed ID: 26431796
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparative analysis of toxic components in different medicinal parts of Gynura japonica and its toxicity assessment on mice.
    Xiong A; Shao Y; Fang L; Yang X; Zhang S; Zheng J; Ding W; Yang L; Wang Z
    Phytomedicine; 2019 Feb; 54():77-88. PubMed ID: 30668385
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum.
    Lin G; Wang JY; Li N; Li M; Gao H; Ji Y; Zhang F; Wang H; Zhou Y; Ye Y; Xu HX; Zheng J
    J Hepatol; 2011 Apr; 54(4):666-73. PubMed ID: 21146894
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyrrolizidine Alkaloid-Induced Hepatotoxicity Associated with the Formation of Reactive Metabolite-Derived Pyrrole-Protein Adducts.
    Ma J; Li M; Li N; Chan WY; Lin G
    Toxins (Basel); 2021 Oct; 13(10):. PubMed ID: 34679016
    [TBL] [Abstract][Full Text] [Related]  

  • 11. First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans.
    Yang M; Ruan J; Gao H; Li N; Ma J; Xue J; Ye Y; Fu PP; Wang J; Lin G
    Arch Toxicol; 2017 Dec; 91(12):3913-3925. PubMed ID: 28620673
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China.
    Zhu L; Zhang CY; Li DP; Chen HB; Ma J; Gao H; Ye Y; Wang JY; Fu PP; Lin G
    Acta Pharmacol Sin; 2021 Aug; 42(8):1212-1222. PubMed ID: 33154553
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity.
    Yang M; Ruan J; Fu PP; Lin G
    Chem Biol Interact; 2016 Jan; 243():119-26. PubMed ID: 26365561
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cyanidin-3-O-β-glucoside protects primary mouse hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction and the PI3K/Akt pathway.
    Jiang X; Tang X; Zhang P; Liu G; Guo H
    Biochem Pharmacol; 2014 Jul; 90(2):135-44. PubMed ID: 24821109
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pyrrolizidine alkaloids enhance alcohol-induced hepatocytotoxicity in vitro in normal human hepatocytes.
    Neuman MG; Cohen LB; Steenkamp V
    Eur Rev Med Pharmacol Sci; 2017 Mar; 21(1 Suppl):53-68. PubMed ID: 28379594
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Involvement of Bcl-xL degradation and mitochondrial-mediated apoptotic pathway in pyrrolizidine alkaloids-induced apoptosis in hepatocytes.
    Ji L; Chen Y; Liu T; Wang Z
    Toxicol Appl Pharmacol; 2008 Sep; 231(3):393-400. PubMed ID: 18586292
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.
    Park EJ; Zhao YZ; Kim YC; Sohn DH
    Eur J Pharmacol; 2007 Mar; 559(2-3):115-23. PubMed ID: 17292878
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
    Du K; Ramachandran A; Weemhoff JL; Chavan H; Xie Y; Krishnamurthy P; Jaeschke H
    Toxicol Sci; 2016 Dec; 154(2):214-226. PubMed ID: 27562556
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Triptolide-induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol.
    Zhou L; Zhou C; Feng Z; Liu Z; Zhu H; Zhou X
    J Ethnopharmacol; 2018 Mar; 214():232-239. PubMed ID: 29277608
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Roles of reactive oxygen species and MAP kinases in the primary rat hepatocytes death induced by toosendanin.
    Zhang Y; Qi X; Gong L; Li Y; Liu L; Xue X; Xiao Y; Wu X; Ren J
    Toxicology; 2008 Jul; 249(1):62-8. PubMed ID: 18499325
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.