BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 32629108)

  • 1. The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1.
    Barnard L; Nikolaou N; Louw C; Schiffer L; Gibson H; Gilligan LC; Gangitano E; Snoep J; Arlt W; Tomlinson JW; Storbeck KH
    J Steroid Biochem Mol Biol; 2020 Sep; 202():105724. PubMed ID: 32629108
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Profiles of 5α-Reduced Androgens in Humans and Eels: 5α-Dihydrotestosterone and 11-Ketodihydrotestosterone Are Active Androgens Produced in Eel Gonads.
    Yazawa T; Inaba H; Imamichi Y; Sekiguchi T; Uwada J; Islam MS; Orisaka M; Mikami D; Ida T; Sato T; Miyashiro Y; Takahashi S; Khan MRI; Suzuki N; Umezawa A; Kitano T
    Front Endocrinol (Lausanne); 2021; 12():657360. PubMed ID: 33833737
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 5α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation.
    Schiffer L; Arlt W; Storbeck KH
    J Steroid Biochem Mol Biol; 2024 Jul; 241():106516. PubMed ID: 38582131
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione.
    Swart AC; Schloms L; Storbeck KH; Bloem LM; Toit Td; Quanson JL; Rainey WE; Swart P
    J Steroid Biochem Mol Biol; 2013 Nov; 138():132-42. PubMed ID: 23685396
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice.
    Windahl SH; Andersson N; Börjesson AE; Swanson C; Svensson J; Movérare-Skrtic S; Sjögren K; Shao R; Lagerquist MK; Ohlsson C
    PLoS One; 2011; 6(6):e21402. PubMed ID: 21731732
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates.
    Tsilchorozidou T; Honour JW; Conway GS
    J Clin Endocrinol Metab; 2003 Dec; 88(12):5907-13. PubMed ID: 14671189
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC
    du Toit T; Bloem LM; Quanson JL; Ehlers R; Serafin AM; Swart AC
    J Steroid Biochem Mol Biol; 2017 Feb; 166():54-67. PubMed ID: 27345701
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inverse Regulation of DHT Synthesis Enzymes 5α-Reductase Types 1 and 2 by the Androgen Receptor in Prostate Cancer.
    Audet-Walsh É; Yee T; Tam IS; Giguère V
    Endocrinology; 2017 Apr; 158(4):1015-1021. PubMed ID: 28324044
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis.
    Jin Y; Chen M; Penning TM
    Biochem J; 2014 Aug; 462(1):163-71. PubMed ID: 24894951
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Androgenic correlates of genetic variation in the gene encoding 5alpha-reductase type 1.
    Ellis JA; Panagiotopoulos S; Akdeniz A; Jerums G; Harrap SB
    J Hum Genet; 2005; 50(10):534-537. PubMed ID: 16155734
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
    Westerbacka J; Yki-Järvinen H; Vehkavaara S; Häkkinen AM; Andrew R; Wake DJ; Seckl JR; Walker BR
    J Clin Endocrinol Metab; 2003 Oct; 88(10):4924-31. PubMed ID: 14557475
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens.
    Schiffer L; Bossey A; Kempegowda P; Taylor AE; Akerman I; Scheel-Toellner D; Storbeck KH; Arlt W
    Eur J Endocrinol; 2021 Mar; 184(3):353-363. PubMed ID: 33444228
    [TBL] [Abstract][Full Text] [Related]  

  • 13. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro.
    Gent R; du Toit T; Swart AC
    J Steroid Biochem Mol Biol; 2019 Jul; 191():105369. PubMed ID: 31039398
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C
    Endo S; Morikawa Y; Kudo Y; Suenami K; Matsunaga T; Ikari A; Hara A
    J Steroid Biochem Mol Biol; 2020 May; 199():105586. PubMed ID: 31926269
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?
    Storbeck KH; Bloem LM; Africander D; Schloms L; Swart P; Swart AC
    Mol Cell Endocrinol; 2013 Sep; 377(1-2):135-46. PubMed ID: 23856005
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer.
    Chang KH; Li R; Papari-Zareei M; Watumull L; Zhao YD; Auchus RJ; Sharifi N
    Proc Natl Acad Sci U S A; 2011 Aug; 108(33):13728-33. PubMed ID: 21795608
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Androgens modulate gene expression and specific DNA methylation pattern of steroid 5α-reductases in the frog Silurana tropicalis.
    Bissegger S; Langlois VS
    Gen Comp Endocrinol; 2016 Aug; 234():123-32. PubMed ID: 26987288
    [TBL] [Abstract][Full Text] [Related]  

  • 18. SRD5A1 and SRD5A2 are associated with treatment for benign prostatic hyperplasia with the combination of 5α-reductase inhibitors and α-adrenergic receptor antagonists.
    Gu X; Na R; Huang T; Wang L; Tao S; Tian L; Chen Z; Jiao Y; Kang J; Zheng S; Xu J; Sun J; Qi J
    J Urol; 2013 Aug; 190(2):615-9. PubMed ID: 23499746
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structure of human liver Delta4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis.
    Di Costanzo L; Drury JE; Penning TM; Christianson DW
    J Biol Chem; 2008 Jun; 283(24):16830-9. PubMed ID: 18407998
    [TBL] [Abstract][Full Text] [Related]  

  • 20. CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway.
    van Rooyen D; Yadav R; Scott EE; Swart AC
    J Steroid Biochem Mol Biol; 2020 May; 199():105614. PubMed ID: 32007561
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.