These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

417 related articles for article (PubMed ID: 32630447)

  • 1. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated
    Martins S; Müller-Schiffmann A; Erichsen L; Bohndorf M; Wruck W; Sleegers K; Van Broeckhoven C; Korth C; Adjaye J
    Int J Mol Sci; 2020 Jun; 21(12):. PubMed ID: 32630447
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.
    Korvatska O; Kiianitsa K; Ratushny A; Matsushita M; Beeman N; Chien WM; Satoh JI; Dorschner MO; Keene CD; Bammler TK; Bird TD; Raskind WH
    Front Immunol; 2020; 11():559342. PubMed ID: 33101276
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Differential splicing of neuronal genes in a Trem2*R47H mouse model mimics alterations associated with Alzheimer's disease.
    Pandey RS; Kotredes KP; Sasner M; Howell GR; Carter GW
    BMC Genomics; 2023 Apr; 24(1):172. PubMed ID: 37016304
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
    Xiang X; Piers TM; Wefers B; Zhu K; Mallach A; Brunner B; Kleinberger G; Song W; Colonna M; Herms J; Wurst W; Pocock JM; Haass C
    Mol Neurodegener; 2018 Sep; 13(1):49. PubMed ID: 30185230
    [TBL] [Abstract][Full Text] [Related]  

  • 5. R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.
    Korvatska O; Leverenz JB; Jayadev S; McMillan P; Kurtz I; Guo X; Rumbaugh M; Matsushita M; Girirajan S; Dorschner MO; Kiianitsa K; Yu CE; Brkanac Z; Garden GA; Raskind WH; Bird TD
    JAMA Neurol; 2015 Aug; 72(8):920-7. PubMed ID: 26076170
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
    Ellwanger DC; Wang S; Brioschi S; Shao Z; Green L; Case R; Yoo D; Weishuhn D; Rathanaswami P; Bradley J; Rao S; Cha D; Luan P; Sambashivan S; Gilfillan S; Hasson SA; Foltz IN; van Lookeren Campagne M; Colonna M
    Proc Natl Acad Sci U S A; 2021 Jan; 118(3):. PubMed ID: 33446504
    [TBL] [Abstract][Full Text] [Related]  

  • 7. TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2
    Ren S; Breuillaud L; Yao W; Yin T; Norris KA; Zehntner SP; D'Adamio L
    J Biol Chem; 2021; 296():100089. PubMed ID: 33434745
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
    Popescu AS; Butler CA; Allendorf DH; Piers TM; Mallach A; Roewe J; Reinhardt P; Cinti A; Redaelli L; Boudesco C; Pradier L; Pocock JM; Thornton P; Brown GC
    Glia; 2023 Apr; 71(4):974-990. PubMed ID: 36480007
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains.
    Ma L; Allen M; Sakae N; Ertekin-Taner N; Graff-Radford NR; Dickson DW; Younkin SG; Sevlever D
    Mol Neurodegener; 2016 Nov; 11(1):72. PubMed ID: 27887626
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer's Risk Variant.
    Tambini MD; D'Adamio L
    Sci Rep; 2020 Mar; 10(1):4122. PubMed ID: 32139718
    [TBL] [Abstract][Full Text] [Related]  

  • 11. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss.
    Penney J; Ralvenius WT; Loon A; Cerit O; Dileep V; Milo B; Pao PC; Woolf H; Tsai LH
    Glia; 2024 Feb; 72(2):452-469. PubMed ID: 37969043
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lymphoblast-derived integration-free iPSC line AD-TREM2-3 from a 74 year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.
    Martins S; Yigit H; Bohndorf M; Graffmann N; Fiszl AR; Wruck W; Sleegers K; Van Broeckhoven C; Adjaye J
    Stem Cell Res; 2018 Jul; 30():141-144. PubMed ID: 29902745
    [TBL] [Abstract][Full Text] [Related]  

  • 13. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
    Hall-Roberts H; Agarwal D; Obst J; Smith TB; Monzón-Sandoval J; Di Daniel E; Webber C; James WS; Mead E; Davis JB; Cowley SA
    Alzheimers Res Ther; 2020 Nov; 12(1):151. PubMed ID: 33198789
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.
    Sekiya M; Wang M; Fujisaki N; Sakakibara Y; Quan X; Ehrlich ME; De Jager PL; Bennett DA; Schadt EE; Gandy S; Ando K; Zhang B; Iijima KM
    Genome Med; 2018 Mar; 10(1):26. PubMed ID: 29598827
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer's disease.
    Toomey CE; Heywood W; Benson BC; Packham G; Mills K; Lashley T
    Brain Pathol; 2020 Jul; 30(4):794-810. PubMed ID: 32267026
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.
    Reich M; Paris I; Ebeling M; Dahm N; Schweitzer C; Reinhardt D; Schmucki R; Prasad M; Köchl F; Leist M; Cowley SA; Zhang JD; Patsch C; Gutbier S; Britschgi M
    Front Immunol; 2020; 11():617860. PubMed ID: 33613545
    [TBL] [Abstract][Full Text] [Related]  

  • 17. More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.
    Rosenthal SL; Bamne MN; Wang X; Berman S; Snitz BE; Klunk WE; Sweet RA; Demirci FY; Lopez OL; Kamboh MI
    Neurobiol Aging; 2015 Aug; 36(8):2443.e21-6. PubMed ID: 26058841
    [TBL] [Abstract][Full Text] [Related]  

  • 18. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model.
    Wang Y; Cella M; Mallinson K; Ulrich JD; Young KL; Robinette ML; Gilfillan S; Krishnan GM; Sudhakar S; Zinselmeyer BH; Holtzman DM; Cirrito JR; Colonna M
    Cell; 2015 Mar; 160(6):1061-71. PubMed ID: 25728668
    [TBL] [Abstract][Full Text] [Related]  

  • 19. R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.
    Slattery CF; Beck JA; Harper L; Adamson G; Abdi Z; Uphill J; Campbell T; Druyeh R; Mahoney CJ; Rohrer JD; Kenny J; Lowe J; Leung KK; Barnes J; Clegg SL; Blair M; Nicholas JM; Guerreiro RJ; Rowe JB; Ponto C; Zerr I; Kretzschmar H; Gambetti P; Crutch SJ; Warren JD; Rossor MN; Fox NC; Collinge J; Schott JM; Mead S
    Alzheimers Dement; 2014 Nov; 10(6):602-608.e4. PubMed ID: 25160042
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
    Piers TM; Cosker K; Mallach A; Johnson GT; Guerreiro R; Hardy J; Pocock JM
    FASEB J; 2020 Feb; 34(2):2436-2450. PubMed ID: 31907987
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.