BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

366 related articles for article (PubMed ID: 32652406)

  • 1. Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
    Xie SS; Liu J; Tang C; Pang C; Li Q; Qin Y; Nong X; Zhang Z; Guo J; Cheng M; Tang W; Liang N; Jiang N
    Eur J Med Chem; 2020 Sep; 202():112475. PubMed ID: 32652406
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.
    Yang HL; Cai P; Liu QH; Yang XL; Li F; Wang J; Wu JJ; Wang XB; Kong LY
    Eur J Med Chem; 2017 Sep; 138():715-728. PubMed ID: 28728104
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis and evaluation of cinnamic acid hybrids as multi-target-directed agents for the treatment of Alzheimer's disease.
    Wang K; Shi J; Zhou Y; He Y; Mi J; Yang J; Liu S; Tang X; Liu W; Tan Z; Sang Z
    Bioorg Chem; 2021 Jul; 112():104879. PubMed ID: 33915461
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and in vitro evaluation of 4-aminoalkyl-1(2H)-phthalazinones as potential multifunctional anti-Alzheimer's disease agents.
    Ye C; Xu R; Cao Z; Song Q; Yu G; Shi Y; Liu Z; Liu X; Deng Y
    Bioorg Chem; 2021 Jun; 111():104895. PubMed ID: 33887586
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation.
    Tian C; Qiang X; Song Q; Cao Z; Ye C; He Y; Deng Y; Zhang L
    Bioorg Chem; 2020 Jan; 94():103477. PubMed ID: 31818478
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
    Sang Z; Wang K; Shi J; Liu W; Tan Z
    Eur J Med Chem; 2019 Sep; 178():726-739. PubMed ID: 31229875
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis and evaluation of chalcone Mannich base derivatives as multifunctional agents for the potential treatment of Alzheimer's disease.
    Zhang X; Song Q; Cao Z; Li Y; Tian C; Yang Z; Zhang H; Deng Y
    Bioorg Chem; 2019 Jun; 87():395-408. PubMed ID: 30921741
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.
    Yang HL; Cai P; Liu QH; Yang XL; Fang SQ; Tang YW; Wang C; Wang XB; Kong LY
    Bioorg Med Chem; 2017 Nov; 25(21):5917-5928. PubMed ID: 28988627
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and evaluation of chalcone-Vitamin E-donepezil hybrids as multi-target-directed ligands for the treatment of Alzheimer's disease.
    Sang Z; Song Q; Cao Z; Deng Y; Zhang L
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):69-85. PubMed ID: 34894968
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
    Sang Z; Wang K; Zhang P; Shi J; Liu W; Tan Z
    Eur J Med Chem; 2019 Oct; 180():238-252. PubMed ID: 31310916
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action.
    Elkamhawy A; Kim HJ; Elsherbeny MH; Paik S; Park JH; Gotina L; Abdellattif MH; Gouda NA; Cho J; Lee K; Nim Pae A; Park KD; Roh EJ
    Bioorg Chem; 2021 Nov; 116():105352. PubMed ID: 34562673
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.
    Lan JS; Ding Y; Liu Y; Kang P; Hou JW; Zhang XY; Xie SS; Zhang T
    Eur J Med Chem; 2017 Oct; 139():48-59. PubMed ID: 28797883
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
    Lan JS; Zhang T; Liu Y; Yang J; Xie SS; Liu J; Miao ZY; Ding Y
    Eur J Med Chem; 2017 Jun; 133():184-196. PubMed ID: 28388521
    [TBL] [Abstract][Full Text] [Related]  

  • 14. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents.
    Košak U; Strašek N; Knez D; Jukič M; Žakelj S; Zahirović A; Pišlar A; Brazzolotto X; Nachon F; Kos J; Gobec S
    Eur J Med Chem; 2020 Jul; 197():112282. PubMed ID: 32380361
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
    Bolea I; Juárez-Jiménez J; de Los Ríos C; Chioua M; Pouplana R; Luque FJ; Unzeta M; Marco-Contelles J; Samadi A
    J Med Chem; 2011 Dec; 54(24):8251-70. PubMed ID: 22023459
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.
    Cai P; Fang SQ; Yang HL; Yang XL; Liu QH; Kong LY; Wang XB
    Eur J Med Chem; 2018 Sep; 157():161-176. PubMed ID: 30096650
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.
    Huang M; Xie SS; Jiang N; Lan JS; Kong LY; Wang XB
    Bioorg Med Chem Lett; 2015 Feb; 25(3):508-13. PubMed ID: 25542589
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis and evaluation of resveratrol-indazole hybrids as novel monoamine oxidases inhibitors with amyloid-β aggregation inhibition.
    Lan JS; Liu Y; Hou JW; Yang J; Zhang XY; Zhao Y; Xie SS; Ding Y; Zhang T
    Bioorg Chem; 2018 Feb; 76():130-139. PubMed ID: 29172101
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease.
    Jiang X; Guo J; Zhang C; Gu J; Zhou T; Bai R; Xie Y
    J Enzyme Inhib Med Chem; 2021 Dec; 36(1):2045-2054. PubMed ID: 34607518
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.
    Pisani L; Farina R; Catto M; Iacobazzi RM; Nicolotti O; Cellamare S; Mangiatordi GF; Denora N; Soto-Otero R; Siragusa L; Altomare CD; Carotti A
    J Med Chem; 2016 Jul; 59(14):6791-806. PubMed ID: 27347731
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.