BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

120 related articles for article (PubMed ID: 32663452)

  • 1. Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Na
    Sharma G; Deuis JR; Jia X; Mueller A; Vetter I; Mobli M
    Biochem Pharmacol; 2020 Nov; 181():114148. PubMed ID: 32663452
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes.
    Agwa AJ; Peigneur S; Chow CY; Lawrence N; Craik DJ; Tytgat J; King GF; Henriques ST; Schroeder CI
    J Biol Chem; 2018 Jun; 293(23):9041-9052. PubMed ID: 29703751
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na
    Rupasinghe DB; Herzig V; Vetter I; Dekan Z; Gilchrist J; Bosmans F; Alewood PF; Lewis RJ; King GF
    Biochem Pharmacol; 2020 Nov; 181():114080. PubMed ID: 32511987
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7.
    Klint JK; Chin YK; Mobli M
    Mol Pharmacol; 2015 Dec; 88(6):1002-10. PubMed ID: 26429937
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
    Moyer BD; Murray JK; Ligutti J; Andrews K; Favreau P; Jordan JB; Lee JH; Liu D; Long J; Sham K; Shi L; Stöcklin R; Wu B; Yin R; Yu V; Zou A; Biswas K; Miranda LP
    PLoS One; 2018; 13(5):e0196791. PubMed ID: 29723257
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens.
    Cardoso FC; Dekan Z; Rosengren KJ; Erickson A; Vetter I; Deuis JR; Herzig V; Alewood PF; King GF; Lewis RJ
    Mol Pharmacol; 2015 Aug; 88(2):291-303. PubMed ID: 25979003
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
    Chow CY; Cristofori-Armstrong B; Undheim EA; King GF; Rash LD
    Toxins (Basel); 2015 Jun; 7(7):2494-513. PubMed ID: 26134258
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Evaluation of the Spider (
    Gonçalves TC; Lesport P; Kuylle S; Stura E; Ciolek J; Mourier G; Servent D; Bourinet E; Benoit E; Gilles N
    Toxins (Basel); 2019 Aug; 11(9):. PubMed ID: 31443554
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNaV1.7.
    Thomas-Tran R; Du Bois J
    Proc Natl Acad Sci U S A; 2016 May; 113(21):5856-61. PubMed ID: 27162340
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels.
    Bende NS; Kang E; Herzig V; Bosmans F; Nicholson GM; Mobli M; King GF
    Biochem Pharmacol; 2013 May; 85(10):1542-54. PubMed ID: 23473802
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus.
    Cardoso FC; Dekan Z; Smith JJ; Deuis JR; Vetter I; Herzig V; Alewood PF; King GF; Lewis RJ
    Br J Pharmacol; 2017 Aug; 174(15):2528-2544. PubMed ID: 28542706
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.
    Klint JK; Smith JJ; Vetter I; Rupasinghe DB; Er SY; Senff S; Herzig V; Mobli M; Lewis RJ; Bosmans F; King GF
    Br J Pharmacol; 2015 May; 172(10):2445-58. PubMed ID: 25754331
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.
    Henriques ST; Deplazes E; Lawrence N; Cheneval O; Chaousis S; Inserra M; Thongyoo P; King GF; Mark AE; Vetter I; Craik DJ; Schroeder CI
    J Biol Chem; 2016 Aug; 291(33):17049-65. PubMed ID: 27311819
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa
    Agwa AJ; Lawrence N; Deplazes E; Cheneval O; Chen RM; Craik DJ; Schroeder CI; Henriques ST
    Biochim Biophys Acta Biomembr; 2017 May; 1859(5):835-844. PubMed ID: 28115115
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7-selective peptide--protoxin II.
    Park JH; Carlin KP; Wu G; Ilyin VI; Kyle DJ
    J Pept Sci; 2012 Jul; 18(7):442-8. PubMed ID: 22605564
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.
    Rahnama S; Deuis JR; Cardoso FC; Ramanujam V; Lewis RJ; Rash LD; King GF; Vetter I; Mobli M
    PLoS One; 2017; 12(3):e0173551. PubMed ID: 28301520
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A complicated complex: Ion channels, voltage sensing, cell membranes and peptide inhibitors.
    Zhang AH; Sharma G; Undheim EAB; Jia X; Mobli M
    Neurosci Lett; 2018 Jul; 679():35-47. PubMed ID: 29684532
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.
    Agwa AJ; Tran P; Mueller A; Tran HNT; Deuis JR; Israel MR; McMahon KL; Craik DJ; Vetter I; Schroeder CI
    J Biol Chem; 2020 Apr; 295(15):5067-5080. PubMed ID: 32139508
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel Na
    Tran HNT; Tran P; Deuis JR; Agwa AJ; Zhang AH; Vetter I; Schroeder CI
    Bioconjug Chem; 2020 Jan; 31(1):64-73. PubMed ID: 31790574
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1.
    Murray JK; Long J; Zou A; Ligutti J; Andrews KL; Poppe L; Biswas K; Moyer BD; McDonough SI; Miranda LP
    J Med Chem; 2016 Mar; 59(6):2704-17. PubMed ID: 26890998
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.