BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

136 related articles for article (PubMed ID: 32673492)

  • 1. Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
    Sarkar D; Olejniczak ET; Phan J; Coker JA; Sai J; Arnold A; Beesetty Y; Waterson AG; Fesik SW
    J Med Chem; 2020 Aug; 63(15):8325-8337. PubMed ID: 32673492
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
    Hodges TR; Abbott JR; Little AJ; Sarkar D; Salovich JM; Howes JE; Akan DT; Sai J; Arnold AL; Browning C; Burns MC; Sobolik T; Sun Q; Beesetty Y; Coker JA; Scharn D; Stadtmueller H; Rossanese OW; Phan J; Waterson AG; McConnell DB; Fesik SW
    J Med Chem; 2018 Oct; 61(19):8875-8894. PubMed ID: 30205005
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles.
    Liao TJ; Jang H; Fushman D; Nussinov R
    Biophys J; 2018 Aug; 115(4):629-641. PubMed ID: 30097175
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1.
    Howes JE; Akan DT; Burns MC; Rossanese OW; Waterson AG; Fesik SW
    Mol Cancer Ther; 2018 May; 17(5):1051-1060. PubMed ID: 29440291
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
    Hillig RC; Sautier B; Schroeder J; Moosmayer D; Hilpmann A; Stegmann CM; Werbeck ND; Briem H; Boemer U; Weiske J; Badock V; Mastouri J; Petersen K; Siemeister G; Kahmann JD; Wegener D; Böhnke N; Eis K; Graham K; Wortmann L; von Nussbaum F; Bader B
    Proc Natl Acad Sci U S A; 2019 Feb; 116(7):2551-2560. PubMed ID: 30683722
    [TBL] [Abstract][Full Text] [Related]  

  • 6. High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
    Burns MC; Howes JE; Sun Q; Little AJ; Camper DV; Abbott JR; Phan J; Lee T; Waterson AG; Rossanese OW; Fesik SW
    Anal Biochem; 2018 May; 548():44-52. PubMed ID: 29444450
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Membrane-dependent signal integration by the Ras activator Son of sevenless.
    Gureasko J; Galush WJ; Boykevisch S; Sondermann H; Bar-Sagi D; Groves JT; Kuriyan J
    Nat Struct Mol Biol; 2008 May; 15(5):452-61. PubMed ID: 18454158
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Ras-induced conformational switch in the Ras activator Son of sevenless.
    Freedman TS; Sondermann H; Friedland GD; Kortemme T; Bar-Sagi D; Marqusee S; Kuriyan J
    Proc Natl Acad Sci U S A; 2006 Nov; 103(45):16692-7. PubMed ID: 17075039
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution.
    Vo U; Vajpai N; Embrey KJ; Golovanov AP
    Sci Rep; 2016 Jul; 6():29706. PubMed ID: 27412770
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
    Abbott JR; Hodges TR; Daniels RN; Patel PA; Kennedy JP; Howes JE; Akan DT; Burns MC; Sai J; Sobolik T; Beesetty Y; Lee T; Rossanese OW; Phan J; Waterson AG; Fesik SW
    J Med Chem; 2018 Jul; 61(14):6002-6017. PubMed ID: 29856609
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Targeting RAS oncogenesis with SOS1 inhibitors.
    Hillig RC; Bader B
    Adv Cancer Res; 2022; 153():169-203. PubMed ID: 35101230
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence.
    Vo U; Vajpai N; Flavell L; Bobby R; Breeze AL; Embrey KJ; Golovanov AP
    J Biol Chem; 2016 Jan; 291(4):1703-1718. PubMed ID: 26565026
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.
    Margarit SM; Sondermann H; Hall BE; Nagar B; Hoelz A; Pirruccello M; Bar-Sagi D; Kuriyan J
    Cell; 2003 Mar; 112(5):685-95. PubMed ID: 12628188
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK.
    Kamioka Y; Yasuda S; Fujita Y; Aoki K; Matsuda M
    J Biol Chem; 2010 Oct; 285(43):33540-33548. PubMed ID: 20724475
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.
    Winter JJ; Anderson M; Blades K; Brassington C; Breeze AL; Chresta C; Embrey K; Fairley G; Faulder P; Finlay MR; Kettle JG; Nowak T; Overman R; Patel SJ; Perkins P; Spadola L; Tart J; Tucker JA; Wrigley G
    J Med Chem; 2015 Mar; 58(5):2265-74. PubMed ID: 25695162
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.
    Roose JP; Mollenauer M; Ho M; Kurosaki T; Weiss A
    Mol Cell Biol; 2007 Apr; 27(7):2732-45. PubMed ID: 17283063
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate.
    Lee YK; Low-Nam ST; Chung JK; Hansen SD; Lam HYM; Alvarez S; Groves JT
    Nat Commun; 2017 Apr; 8():15061. PubMed ID: 28452363
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
    Burns MC; Sun Q; Daniels RN; Camper D; Kennedy JP; Phan J; Olejniczak ET; Lee T; Waterson AG; Rossanese OW; Fesik SW
    Proc Natl Acad Sci U S A; 2014 Mar; 111(9):3401-6. PubMed ID: 24550516
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless.
    Gureasko J; Kuchment O; Makino DL; Sondermann H; Bar-Sagi D; Kuriyan J
    Proc Natl Acad Sci U S A; 2010 Feb; 107(8):3430-5. PubMed ID: 20133692
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Extending the Lifetime of Native GTP-Bound Ras for Site-Resolved NMR Measurements: Quantifying the Allosteric Dynamics.
    Chen X; Yao H; Wang H; Mao Y; Liu D; Long D
    Angew Chem Int Ed Engl; 2019 Feb; 58(9):2730-2733. PubMed ID: 30681242
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.