138 related articles for article (PubMed ID: 32691223)
21. Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.
Bartkowiak B; Greenleaf AL
J Biol Chem; 2015 Jan; 290(3):1786-95. PubMed ID: 25429106
[TBL] [Abstract][Full Text] [Related]
22. Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
Ito M; Tanaka T; Toita A; Uchiyama N; Kokubo H; Morishita N; Klein MG; Zou H; Murakami M; Kondo M; Sameshima T; Araki S; Endo S; Kawamoto T; Morin GB; Aparicio SA; Nakanishi A; Maezaki H; Imaeda Y
J Med Chem; 2018 Sep; 61(17):7710-7728. PubMed ID: 30067358
[TBL] [Abstract][Full Text] [Related]
23. Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma.
Geng M; Yang Y; Cao X; Dang L; Zhang T; Zhang L
Biochem Biophys Res Commun; 2019 Dec; 520(3):544-550. PubMed ID: 31615655
[TBL] [Abstract][Full Text] [Related]
24. CDK12: an emerging therapeutic target for cancer.
Lui GYL; Grandori C; Kemp CJ
J Clin Pathol; 2018 Nov; 71(11):957-962. PubMed ID: 30104286
[TBL] [Abstract][Full Text] [Related]
25. Cyclin-dependent kinase 7 (CDK7) is an emerging prognostic biomarker and therapeutic target in osteosarcoma.
Ma H; Dean DC; Wei R; Hornicek FJ; Duan Z
Ther Adv Musculoskelet Dis; 2021; 13():1759720X21995069. PubMed ID: 34104229
[TBL] [Abstract][Full Text] [Related]
26. CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
Chirackal Manavalan AP; Pilarova K; Kluge M; Bartholomeeusen K; Rajecky M; Oppelt J; Khirsariya P; Paruch K; Krejci L; Friedel CC; Blazek D
EMBO Rep; 2019 Sep; 20(9):e47592. PubMed ID: 31347271
[TBL] [Abstract][Full Text] [Related]
27. Expression pattern of CDK12 protein in gastric cancer and its positive correlation with CD8
Ji J; Zhou C; Wu J; Cai Q; Shi M; Zhang H; Yu Y; Zhu Z; Zhang J
Int J Med Sci; 2019; 16(8):1142-1148. PubMed ID: 31523177
[No Abstract] [Full Text] [Related]
28. Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.
Li X; Chatterjee N; Spirohn K; Boutros M; Bohmann D
Sci Rep; 2016 Feb; 6():21455. PubMed ID: 26911346
[TBL] [Abstract][Full Text] [Related]
29. Development, validation, and evaluation of a deep learning model to screen cyclin-dependent kinase 12 inhibitors in cancers.
Wen T; Wang J; Lu R; Tan S; Li P; Yao X; Liu H; Yi Z; Li L; Liu S; Gao P; Qian H; Xie G; Ma F
Eur J Med Chem; 2023 Mar; 250():115199. PubMed ID: 36827953
[TBL] [Abstract][Full Text] [Related]
30. CRISPR screening identifies CDK12 as a conservative vulnerability of prostate cancer.
Lei H; Wang Z; Jiang D; Liu F; Liu M; Lei X; Yang Y; He B; Yan M; Huang H; Liu Q; Pang J
Cell Death Dis; 2021 Jul; 12(8):740. PubMed ID: 34315855
[TBL] [Abstract][Full Text] [Related]
31. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.
Choi SH; Martinez TF; Kim S; Donaldson C; Shokhirev MN; Saghatelian A; Jones KA
Genes Dev; 2019 Apr; 33(7-8):418-435. PubMed ID: 30819820
[TBL] [Abstract][Full Text] [Related]
32. The structure and substrate specificity of human Cdk12/Cyclin K.
Bösken CA; Farnung L; Hintermair C; Merzel Schachter M; Vogel-Bachmayr K; Blazek D; Anand K; Fisher RP; Eick D; Geyer M
Nat Commun; 2014 Mar; 5():3505. PubMed ID: 24662513
[TBL] [Abstract][Full Text] [Related]
33. CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation.
Tellier M; Zaborowska J; Caizzi L; Mohammad E; Velychko T; Schwalb B; Ferrer-Vicens I; Blears D; Nojima T; Cramer P; Murphy S
Nucleic Acids Res; 2020 Aug; 48(14):7712-7727. PubMed ID: 32805052
[TBL] [Abstract][Full Text] [Related]
34. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling.
Henry KL; Kellner D; Bajrami B; Anderson JE; Beyna M; Bhisetti G; Cameron T; Capacci AG; Bertolotti-Ciarlet A; Feng J; Gao B; Hopkins B; Jenkins T; Li K; May-Dracka T; Murugan P; Wei R; Zeng W; Allaire N; Buckler A; Loh C; Juhasz P; Lucas B; Ennis KA; Vollman E; Cahir-McFarland E; Hett EC; Ols ML
Sci Signal; 2018 Jul; 11(541):. PubMed ID: 30065029
[TBL] [Abstract][Full Text] [Related]
35. Th e role of CDK12 in tumor bio logy.
Dzimková M; Procházková J; Klát J; Kohoutek J
Klin Onkol; 2020; 33(4):260-267. PubMed ID: 32894954
[TBL] [Abstract][Full Text] [Related]
36. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
Chen HR; Lin GT; Huang CK; Fann MJ
Exp Neurol; 2014 Nov; 261():10-21. PubMed ID: 24999027
[TBL] [Abstract][Full Text] [Related]
37. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
Dubbury SJ; Boutz PL; Sharp PA
Nature; 2018 Dec; 564(7734):141-145. PubMed ID: 30487607
[TBL] [Abstract][Full Text] [Related]
38. Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor.
Niu T; Li K; Jiang L; Zhou Z; Hong J; Chen X; Dong X; He Q; Cao J; Yang B; Zhu CL
Eur J Med Chem; 2022 Jan; 228():114012. PubMed ID: 34864331
[TBL] [Abstract][Full Text] [Related]
39. Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.
Liu Y; Hao M; Leggett AL; Gao Y; Ficarro SB; Che J; He Z; Olson CM; Marto JA; Kwiatkowski NP; Zhang T; Gray NS
J Med Chem; 2020 Jul; 63(13):6708-6726. PubMed ID: 32502343
[TBL] [Abstract][Full Text] [Related]
40. Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.
Bartkowiak B; Yan C; Greenleaf AL
Biochim Biophys Acta; 2015 Sep; 1849(9):1179-87. PubMed ID: 26189575
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]