227 related articles for article (PubMed ID: 32715544)
1. Tumorigenic p53 mutants undergo common structural disruptions including conversion to α-sheet structure.
Bromley D; Daggett V
Protein Sci; 2020 Sep; 29(9):1983-1999. PubMed ID: 32715544
[TBL] [Abstract][Full Text] [Related]
2. Common cancer mutations R175H and R273H drive the p53 DNA-binding domain towards aggregation-prone conformations.
Li L; Li X; Tang Y; Lao Z; Lei J; Wei G
Phys Chem Chem Phys; 2020 May; 22(17):9225-9232. PubMed ID: 32307496
[TBL] [Abstract][Full Text] [Related]
3. Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer.
Silva JL; Cino EA; Soares IN; Ferreira VF; A P de Oliveira G
Acc Chem Res; 2018 Jan; 51(1):181-190. PubMed ID: 29260852
[TBL] [Abstract][Full Text] [Related]
4. An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein.
Bromley D; Bauer MR; Fersht AR; Daggett V
Protein Eng Des Sel; 2016 Sep; 29(9):377-90. PubMed ID: 27503952
[TBL] [Abstract][Full Text] [Related]
5. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations.
Suad O; Rozenberg H; Brosh R; Diskin-Posner Y; Kessler N; Shimon LJ; Frolow F; Liran A; Rotter V; Shakked Z
J Mol Biol; 2009 Jan; 385(1):249-65. PubMed ID: 18996393
[TBL] [Abstract][Full Text] [Related]
6. Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domain.
Calhoun S; Daggett V
Biochemistry; 2011 Jun; 50(23):5345-53. PubMed ID: 21561095
[TBL] [Abstract][Full Text] [Related]
7. Dynamic perspectives into the mechanisms of mutation-induced p53-DNA binding loss and inactivation using active perturbation theory: Structural and molecular insights toward the design of potent reactivators in cancer therapy.
Olotu FA; Soliman MES
J Cell Biochem; 2019 Jan; 120(1):951-966. PubMed ID: 30160791
[TBL] [Abstract][Full Text] [Related]
8. Effect of Mutation on an Aggregation-Prone Segment of p53: From Monomer to Dimer to Multimer.
Das A; Makarov DE
J Phys Chem B; 2016 Nov; 120(45):11665-11673. PubMed ID: 27775362
[TBL] [Abstract][Full Text] [Related]
9. Insights into the Effect of the G245S Single Point Mutation on the Structure of p53 and the Binding of the Protein to DNA.
Lepre MG; Omar SI; Grasso G; Morbiducci U; Deriu MA; Tuszynski JA
Molecules; 2017 Aug; 22(8):. PubMed ID: 28813011
[TBL] [Abstract][Full Text] [Related]
10. R248Q mutation--Beyond p53-DNA binding.
Ng JW; Lama D; Lukman S; Lane DP; Verma CS; Sim AY
Proteins; 2015 Dec; 83(12):2240-50. PubMed ID: 26442703
[TBL] [Abstract][Full Text] [Related]
11. Wild type p53 function in p53
Sundar D; Yu Y; Katiyar SP; Putri JF; Dhanjal JK; Wang J; Sari AN; Kolettas E; Kaul SC; Wadhwa R
J Exp Clin Cancer Res; 2019 Feb; 38(1):103. PubMed ID: 30808373
[TBL] [Abstract][Full Text] [Related]
12. Reversible amyloid formation by the p53 tetramerization domain and a cancer-associated mutant.
Lee AS; Galea C; DiGiammarino EL; Jun B; Murti G; Ribeiro RC; Zambetti G; Schultz CP; Kriwacki RW
J Mol Biol; 2003 Mar; 327(3):699-709. PubMed ID: 12634062
[TBL] [Abstract][Full Text] [Related]
13. Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study.
Kamaraj B; Bogaerts A
PLoS One; 2015; 10(8):e0134638. PubMed ID: 26244575
[TBL] [Abstract][Full Text] [Related]
14. Molecular dynamics study on the inhibition mechanisms of ReACp53 peptide for p53-R175H mutant aggregation.
Lei J; Cai M; Shen Y; Lin D; Deng X
Phys Chem Chem Phys; 2021 Oct; 23(40):23032-23041. PubMed ID: 34612239
[TBL] [Abstract][Full Text] [Related]
15. Hot-spot mutants of p53 core domain evince characteristic local structural changes.
Wong KB; DeDecker BS; Freund SM; Proctor MR; Bycroft M; Fersht AR
Proc Natl Acad Sci U S A; 1999 Jul; 96(15):8438-42. PubMed ID: 10411893
[TBL] [Abstract][Full Text] [Related]
16. Analysis of the
Chitrala KN; Nagarkatti M; Nagarkatti P; Yeguvapalli S
Int J Mol Sci; 2019 Jun; 20(12):. PubMed ID: 31216622
[TBL] [Abstract][Full Text] [Related]
17. Structure-function-rescue: the diverse nature of common p53 cancer mutants.
Joerger AC; Fersht AR
Oncogene; 2007 Apr; 26(15):2226-42. PubMed ID: 17401432
[TBL] [Abstract][Full Text] [Related]
18. Insight into a novel p53 single point mutation (G389E) by Molecular Dynamics Simulations.
Pirolli D; Carelli Alinovi C; Capoluongo E; Satta MA; Concolino P; Giardina B; De Rosa MC
Int J Mol Sci; 2010 Dec; 12(1):128-40. PubMed ID: 21339981
[TBL] [Abstract][Full Text] [Related]
19. Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket.
Pradhan MR; Siau JW; Kannan S; Nguyen MN; Ouaray Z; Kwoh CK; Lane DP; Ghadessy F; Verma CS
Nucleic Acids Res; 2019 Feb; 47(4):1637-1652. PubMed ID: 30649466
[TBL] [Abstract][Full Text] [Related]
20. Prediction of dual agents as an activator of mutant p53 and inhibitor of Hsp90 by docking, molecular dynamic simulation and virtual screening.
Abbasi M; Sadeghi-Aliabadi H; Hassanzadeh F; Amanlou M
J Mol Graph Model; 2015 Sep; 61():186-95. PubMed ID: 26277488
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
