146 related articles for article (PubMed ID: 32730943)
1. Mechanistic insights into the activation of ester prodrugs of 666-15.
Xie F; Martín-Acosta P; Li BX; Xiao X
Bioorg Med Chem Lett; 2020 Oct; 30(19):127455. PubMed ID: 32730943
[TBL] [Abstract][Full Text] [Related]
2. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with
Xie F; Fan Q; Li BX; Xiao X
J Med Chem; 2019 Dec; 62(24):11423-11429. PubMed ID: 31765143
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis and biological evaluation of regioisomers of 666-15 as inhibitors of CREB-mediated gene transcription.
Xie F; Li BX; Xiao X
Bioorg Med Chem Lett; 2017 Feb; 27(4):994-998. PubMed ID: 28073675
[TBL] [Abstract][Full Text] [Related]
4. Synthesis, chemical and enzymatic hydrolysis, and bioavailability evaluation in rabbits of metronidazole amino acid ester prodrugs with enhanced water solubility.
Mahfouz NM; Hassan MA
J Pharm Pharmacol; 2001 Jun; 53(6):841-8. PubMed ID: 11428660
[TBL] [Abstract][Full Text] [Related]
5. Synthesis, chemical and enzymatic hydrolysis, and aqueous solubility of amino acid ester prodrugs of 3-carboranyl thymidine analogs for boron neutron capture therapy of brain tumors.
Hasabelnaby S; Goudah A; Agarwal HK; abd Alla MS; Tjarks W
Eur J Med Chem; 2012 Sep; 55():325-34. PubMed ID: 22889558
[TBL] [Abstract][Full Text] [Related]
6. Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1.
Takahashi M; Ogawa T; Kashiwagi H; Fukushima F; Yoshitsugu M; Haba M; Hosokawa M
Bioorg Med Chem Lett; 2018 Apr; 28(6):997-1000. PubMed ID: 29503023
[TBL] [Abstract][Full Text] [Related]
7. Improved Protease-Targeting and Biopharmaceutical Properties of Novel Prodrugs of Ganciclovir.
Sun K; Xu H; Hilfinger JL; Lee KD; Provoda CJ; Sabit H; Amidon GL
Mol Pharm; 2018 Feb; 15(2):410-419. PubMed ID: 29251944
[TBL] [Abstract][Full Text] [Related]
8. Novel approaches for designing 5'-O-ester prodrugs of 3'-azido-2', 3'-dideoxythymidine (AZT).
Parang K; Wiebe LI; Knaus EE
Curr Med Chem; 2000 Oct; 7(10):995-1039. PubMed ID: 10911016
[TBL] [Abstract][Full Text] [Related]
9. Prodrug forms of N-[(4-deoxy-4-amino-10-methyl)pteroyl]glutamate-gamma-[psiP(O)(OH)]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability.
Feng Y; Coward JK
J Med Chem; 2006 Jan; 49(2):770-88. PubMed ID: 16420062
[TBL] [Abstract][Full Text] [Related]
10. Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties.
Nielsen NM; Bundgaard H
J Pharm Sci; 1988 Apr; 77(4):285-98. PubMed ID: 3379586
[TBL] [Abstract][Full Text] [Related]
11. Systemic Inhibition of CREB is Well-tolerated in vivo.
Li BX; Gardner R; Xue C; Qian DZ; Xie F; Thomas G; Kazmierczak SC; Habecker BA; Xiao X
Sci Rep; 2016 Oct; 6():34513. PubMed ID: 27694829
[TBL] [Abstract][Full Text] [Related]
12. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity.
Xie F; Li BX; Kassenbrock A; Xue C; Wang X; Qian DZ; Sears RC; Xiao X
J Med Chem; 2015 Jun; 58(12):5075-87. PubMed ID: 26023867
[TBL] [Abstract][Full Text] [Related]
13. Synthesis, enzymatic hydrolysis and physico-chemical properties of N-substituted 4-(aminomethyl)benzoate diester prodrugs of ganciclovir.
Jensen E; Bundgaard H
Acta Pharm Nord; 1991; 3(4):243-7. PubMed ID: 1781915
[TBL] [Abstract][Full Text] [Related]
14. Synthesis and in vitro evaluation of aminoacyloxyalkyl esters of 2-(6-methoxy-2-naphthyl)propionic acid as novel naproxen prodrugs for dermal drug delivery.
Rautio J; Nevalainen T; Taipale H; Vepsäläinen J; Gynther J; Pedersen T; Järvinen T
Pharm Res; 1999 Aug; 16(8):1172-8. PubMed ID: 10468016
[TBL] [Abstract][Full Text] [Related]
15. Chlorzoxazone esters of some non-steroidal anti-inflammatory (NSAI) carboxylic acids as mutual prodrugs: design, synthesis, pharmacological investigations and docking studies.
Abdel-Azeem AZ; Abdel-Hafez AA; El-Karamany GS; Farag HH
Bioorg Med Chem; 2009 May; 17(10):3665-70. PubMed ID: 19398345
[TBL] [Abstract][Full Text] [Related]
16. Lipophilic pyrazinoic acid amide and ester prodrugs stability, activation and activity against M. tuberculosis.
Simões MF; Valente E; Gómez MJ; Anes E; Constantino L
Eur J Pharm Sci; 2009 Jun; 37(3-4):257-63. PubMed ID: 19491013
[TBL] [Abstract][Full Text] [Related]
17. New water-soluble prodrugs of HIV protease inhibitors based on O-->N intramolecular acyl migration.
Hamada Y; Ohtake J; Sohma Y; Kimura T; Hayashi Y; Kiso Y
Bioorg Med Chem; 2002 Dec; 10(12):4155-67. PubMed ID: 12413869
[TBL] [Abstract][Full Text] [Related]
18. Modulating lipophilicity of rohitukine via prodrug approach: Preparation, characterization, and in vitro enzymatic hydrolysis in biorelevant media.
Kumar V; Bharate SS; Vishwakarma RA
Eur J Pharm Sci; 2016 Sep; 92():203-11. PubMed ID: 27422078
[TBL] [Abstract][Full Text] [Related]
19. Morpholinoalkyl ester prodrugs of diclofenac: synthesis, in vitro and in vivo evaluation.
Tammara VK; Narurkar MM; Crider AM; Khan MA
J Pharm Sci; 1994 May; 83(5):644-8. PubMed ID: 8071813
[TBL] [Abstract][Full Text] [Related]
20. Novel double prodrugs of the iron chelator N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED): Synthesis, characterization, and investigation of activation by chemical hydrolysis and oxidation.
Thiele NA; Abboud KA; Sloan KB
Eur J Med Chem; 2016 Aug; 118():193-207. PubMed ID: 27128183
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]