BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 32738993)

  • 1. Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling.
    Fujii S; Kikuchi E; Watanabe Y; Suzuyama H; Ishigami-Yuasa M; Mori T; Isobe K; Uchida S; Kagechika H
    Bioorg Med Chem Lett; 2020 Sep; 30(17):127408. PubMed ID: 32738993
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Development of WNK signaling inhibitors as a new class of antihypertensive drugs.
    Ishigami-Yuasa M; Watanabe Y; Mori T; Masuno H; Fujii S; Kikuchi E; Uchida S; Kagechika H
    Bioorg Med Chem; 2017 Jul; 25(14):3845-3852. PubMed ID: 28566208
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents.
    Fujii S; Kikuchi E; Suzuyama H; Watanabe Y; Ishigami-Yuasa M; Masuno H; Mori T; Isobe K; Uchida S; Kagechika H
    ChemMedChem; 2021 Sep; 16(18):2817-2822. PubMed ID: 34109743
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.
    Nishida H; Sohara E; Nomura N; Chiga M; Alessi DR; Rai T; Sasaki S; Uchida S
    Hypertension; 2012 Oct; 60(4):981-90. PubMed ID: 22949526
    [TBL] [Abstract][Full Text] [Related]  

  • 5. WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension.
    Brown A; Meor Azlan NF; Wu Z; Zhang J
    Acta Pharmacol Sin; 2021 Apr; 42(4):508-517. PubMed ID: 32724175
    [TBL] [Abstract][Full Text] [Related]  

  • 6. WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia.
    Thomson MN; Cuevas CA; Bewarder TM; Dittmayer C; Miller LN; Si J; Cornelius RJ; Su XT; Yang CL; McCormick JA; Hadchouel J; Ellison DH; Bachmann S; Mutig K
    Am J Physiol Renal Physiol; 2020 Jan; 318(1):F216-F228. PubMed ID: 31736353
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy.
    Mori T; Kikuchi E; Watanabe Y; Fujii S; Ishigami-Yuasa M; Kagechika H; Sohara E; Rai T; Sasaki S; Uchida S
    Biochem J; 2013 Nov; 455(3):339-45. PubMed ID: 23981180
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
    Richardson C; Rafiqi FH; Karlsson HK; Moleleki N; Vandewalle A; Campbell DG; Morrice NA; Alessi DR
    J Cell Sci; 2008 Mar; 121(Pt 5):675-84. PubMed ID: 18270262
    [TBL] [Abstract][Full Text] [Related]  

  • 9. [WNK-SPAK-SLC12A signal cascade is a new therapeutic target for hypertension].
    Kikuchi E; Mori T; Uchida S
    Nihon Rinsho; 2015 Sep; 73(9):1597-605. PubMed ID: 26394527
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters.
    Kikuchi E; Mori T; Zeniya M; Isobe K; Ishigami-Yuasa M; Fujii S; Kagechika H; Ishihara T; Mizushima T; Sasaki S; Sohara E; Rai T; Uchida S
    J Am Soc Nephrol; 2015 Jul; 26(7):1525-36. PubMed ID: 25377078
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.
    Alessi DR; Zhang J; Khanna A; Hochdörfer T; Shang Y; Kahle KT
    Sci Signal; 2014 Jul; 7(334):re3. PubMed ID: 25028718
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke.
    Josiah SS; Meor Azlan NF; Zhang J
    Int J Mol Sci; 2021 Jan; 22(3):. PubMed ID: 33513812
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.
    Chiga M; Rai T; Yang SS; Ohta A; Takizawa T; Sasaki S; Uchida S
    Kidney Int; 2008 Dec; 74(11):1403-9. PubMed ID: 18800028
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.
    de Los Heros P; Alessi DR; Gourlay R; Campbell DG; Deak M; Macartney TJ; Kahle KT; Zhang J
    Biochem J; 2014 Mar; 458(3):559-73. PubMed ID: 24393035
    [TBL] [Abstract][Full Text] [Related]  

  • 15. SPAK and WNK kinases: a new target for blood pressure treatment?
    Glover M; O'shaughnessy KM
    Curr Opin Nephrol Hypertens; 2011 Jan; 20(1):16-22. PubMed ID: 21088576
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Role of nitric oxide and WNK-SPAK/OSR1-KCC2 signaling in daily changes in GABAergic inhibition in the rat dorsal raphe neurons.
    Kim MJ; Yang HJ; Kim Y; Kang I; Kim SS; Cho YW
    Neuropharmacology; 2018 Jun; 135():355-367. PubMed ID: 29596900
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease.
    Furusho T; Sohara E; Mandai S; Kikuchi H; Takahashi N; Fujimaru T; Hashimoto H; Arai Y; Ando F; Zeniya M; Mori T; Susa K; Isobe K; Nomura N; Yamamoto K; Okado T; Rai T; Uchida S
    Kidney Int; 2020 Apr; 97(4):713-727. PubMed ID: 32059997
    [TBL] [Abstract][Full Text] [Related]  

  • 18. WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.
    Susa K; Sohara E; Takahashi D; Okado T; Rai T; Uchida S
    Biochem Biophys Res Commun; 2017 Sep; 491(3):727-732. PubMed ID: 28743496
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Suppression of WNK1-SPAK/OSR1 Attenuates Bone Cancer Pain by Regulating NKCC1 and KCC2.
    Gao JL; Peng K; Shen MW; Hou YH; Qian XB; Meng XW; Ji FH; Wang LN; Yang JP
    J Pain; 2019 Dec; 20(12):1416-1428. PubMed ID: 31085334
    [TBL] [Abstract][Full Text] [Related]  

  • 20. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
    Moriguchi T; Urushiyama S; Hisamoto N; Iemura S; Uchida S; Natsume T; Matsumoto K; Shibuya H
    J Biol Chem; 2005 Dec; 280(52):42685-93. PubMed ID: 16263722
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.