These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
223 related articles for article (PubMed ID: 32751071)
1. Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine. Gmeiner WH Molecules; 2020 Jul; 25(15):. PubMed ID: 32751071 [TBL] [Abstract][Full Text] [Related]
2. On the rational development of a new drug: the example of the fluorinated pyrimidines. Heidelberger C Cancer Treat Rep; 1981; 65 Suppl 3():3-9. PubMed ID: 7346154 [TBL] [Abstract][Full Text] [Related]
3. Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells. Murakami Y; Kazuno H; Emura T; Tsujimoto H; Suzuki N; Fukushima M Int J Oncol; 2000 Aug; 17(2):277-83. PubMed ID: 10891536 [TBL] [Abstract][Full Text] [Related]
4. Significance of thymidylate synthase activity in renal cell carcinoma. Mizutani Y; Wada H; Yoshida O; Fukushima M; Nonomura M; Nakao M; Miki T Clin Cancer Res; 2003 Apr; 9(4):1453-60. PubMed ID: 12684419 [TBL] [Abstract][Full Text] [Related]
5. In-vitro differential metabolism and activity of 5-fluorouracil between short-term, high-dose and long-term, low-dose treatments in human squamous carcinoma cells. Qin B; Tanaka R; Ariyama H; Shibata Y; Arita S; Kusaba H; Baba E; Harada M; Nakano S Anticancer Drugs; 2006 Apr; 17(4):439-43. PubMed ID: 16550002 [TBL] [Abstract][Full Text] [Related]
6. Chronic exposure of colorectal cancer cells in culture to fluoropyrimidine analogs induces thymidylate synthase and suppresses p53. A molecular explanation for the mechanism of 5-FU resistance. Subbarayan PR; Sarkar M; Nelson G; Benitez E; Singhal S; Ardalan B Anticancer Res; 2010 Apr; 30(4):1149-56. PubMed ID: 20530421 [TBL] [Abstract][Full Text] [Related]
7. Transcription and activity of 5-fluorouracil converting enzymes in fluoropyrimidine resistance in colon cancer in vitro. Mader RM; Sieder AE; Braun J; Rizovski B; Kalipciyan M; Mueller MW; Jakesz R; Rainer H; Steger GG Biochem Pharmacol; 1997 Dec; 54(11):1233-42. PubMed ID: 9416974 [TBL] [Abstract][Full Text] [Related]
8. Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells. Inaba M; Naoe Y; Mitsuhashi J Biol Pharm Bull; 1998 Jun; 21(6):569-73. PubMed ID: 9657039 [TBL] [Abstract][Full Text] [Related]
9. A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes. Liao ZY; Sordet O; Zhang HL; Kohlhagen G; Antony S; Gmeiner WH; Pommier Y Cancer Res; 2005 Jun; 65(11):4844-51. PubMed ID: 15930305 [TBL] [Abstract][Full Text] [Related]
10. Dihydropyrimidine dehydrogenase activity and thymidylate synthase level are associated with response to 5-fluorouracil in human colorectal cancer. Araki Y; Isomoto H; Shirouzu K Kurume Med J; 2001; 48(2):93-8. PubMed ID: 11501504 [TBL] [Abstract][Full Text] [Related]
11. Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation. Liu J; Kolath J; Anderson J; Kolar C; Lawson TA; Talmadge J; Gmeiner WH Antisense Nucleic Acid Drug Dev; 1999 Oct; 9(5):481-6. PubMed ID: 10555156 [TBL] [Abstract][Full Text] [Related]
12. Relationship of in vivo antitumor activities of fluorinated pyrimidines to thymidylate synthase activity and intratumoral concentrations of 5-fluorouracil and uracil. Nio Y; Shiraishi T; Tsubono M; Morimoto H; Tseng CC; Kawabata K; Imai S; Tobe T Anticancer Res; 1991; 11(2):607-12. PubMed ID: 2064315 [TBL] [Abstract][Full Text] [Related]
13. Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells. Antosiewicz A; Jarmuła A; Przybylska D; Mosieniak G; Szczepanowska J; Kowalkowska A; Rode W; Cieśla J J Biomol Struct Dyn; 2017 May; 35(7):1474-1490. PubMed ID: 27187663 [TBL] [Abstract][Full Text] [Related]
14. 5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers. Noordhuis P; Holwerda U; Van der Wilt CL; Van Groeningen CJ; Smid K; Meijer S; Pinedo HM; Peters GJ Ann Oncol; 2004 Jul; 15(7):1025-32. PubMed ID: 15205195 [TBL] [Abstract][Full Text] [Related]
15. Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line. Chu E; Zinn S; Boarman D; Allegra CJ Cancer Res; 1990 Sep; 50(18):5834-40. PubMed ID: 1697502 [TBL] [Abstract][Full Text] [Related]
16. The transfection of thymidylate synthase antisense suppresses oncogenic properties of a human colon cancer cell line and augments the antitumor effect of fluorouracil. Matsuoka K; Tsukuda K; Suda M; Kobayashi K; Ota T; Okita A; Watanabe K; Suzuki E; Murakami M; Doihara H; Shimizu N Int J Oncol; 2004 Jan; 24(1):217-22. PubMed ID: 14654960 [TBL] [Abstract][Full Text] [Related]
17. Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats. Yoshisue K; Hironaga K; Yamaguchi S; Yamamoto A; Nagayama S; Kawaguchi Y Cancer Chemother Pharmacol; 2000; 46(1):51-6. PubMed ID: 10912578 [TBL] [Abstract][Full Text] [Related]
18. UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA. Abe S; Kubota T; Otani Y; Furukawa T; Watanabe M; Kumai K; Kitajima M Jpn J Cancer Res; 2000 Nov; 91(11):1192-8. PubMed ID: 11092986 [TBL] [Abstract][Full Text] [Related]
19. Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. Peters GJ; van Groeningen CJ; van der Wilt CL; Meijer S; Smid K; Laurensse E; Pinedo HM Semin Oncol; 1992 Apr; 19(2 Suppl 3):26-35. PubMed ID: 1557655 [TBL] [Abstract][Full Text] [Related]
20. Apoptosis and thymidylate synthase inductions by 5-fluorouracil in gastric cancer cells with or without p53 mutation. Yukimoto K; Nakata B; Muguruma K; Yashiro M; Ohira M; Ishikawa T; Hino M; Hirakawa K Int J Oncol; 2001 Aug; 19(2):373-8. PubMed ID: 11445854 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]