BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 32761352)

  • 1. Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.
    Stocco MR; Tolledo C; Wadji FB; Gonzalez FJ; Miksys S; Tyndale RF
    Mol Neurobiol; 2020 Nov; 57(11):4608-4621. PubMed ID: 32761352
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice.
    Tolledo C; Stocco MR; Miksys S; Gonzalez FJ; Tyndale RF
    Mol Neurobiol; 2020 Jun; 57(6):2509-2520. PubMed ID: 32189192
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses.
    Tolledo EC; Miksys S; Gonzalez FJ; Tyndale RF
    Br J Pharmacol; 2020 Feb; 177(3):701-712. PubMed ID: 31648367
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model.
    Miksys SL; Cheung C; Gonzalez FJ; Tyndale RF
    Drug Metab Dispos; 2005 Oct; 33(10):1495-502. PubMed ID: 16033950
    [TBL] [Abstract][Full Text] [Related]  

  • 5. First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo.
    Zhou K; Khokhar JY; Zhao B; Tyndale RF
    Biochem Pharmacol; 2013 Jun; 85(12):1848-55. PubMed ID: 23623752
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
    Herraiz T; Guillén H; Arán VJ; Idle JR; Gonzalez FJ
    Toxicol Appl Pharmacol; 2006 Nov; 216(3):387-98. PubMed ID: 16870220
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice.
    Qin X; Xie C; Hakenjos JM; MacKenzie KR; Boyd SR; Barzi M; Bissig KD; Young DW; Li F
    Eur J Pharm Sci; 2023 Feb; 181():106358. PubMed ID: 36513193
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of human cytochrome P450 enzymes 3A4 and 2D6 by β-carboline alkaloids, harmine derivatives.
    Zhao T; He YQ; Wang J; Ding KM; Wang CH; Wang ZT
    Phytother Res; 2011 Nov; 25(11):1671-7. PubMed ID: 21433154
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Potential role of CYP2D6 in the central nervous system.
    Cheng J; Zhen Y; Miksys S; Beyoğlu D; Krausz KW; Tyndale RF; Yu A; Idle JR; Gonzalez FJ
    Xenobiotica; 2013 Nov; 43(11):973-84. PubMed ID: 23614566
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.
    Yu AM; Idle JR; Krausz KW; Küpfer A; Gonzalez FJ
    J Pharmacol Exp Ther; 2003 Apr; 305(1):315-22. PubMed ID: 12649384
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The role of CYP2D in rat brain in methamphetamine-induced striatal dopamine and serotonin release and behavioral sensitization.
    Stocco MR; El-Sherbeni AA; Zhao B; Novalen M; Tyndale RF
    Psychopharmacology (Berl); 2021 Jul; 238(7):1791-1804. PubMed ID: 33649968
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment.
    Mann A; Miksys S; Lee A; Mash DC; Tyndale RF
    Neuropharmacology; 2008 Dec; 55(7):1147-55. PubMed ID: 18687346
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines.
    Scheer N; Kapelyukh Y; McEwan J; Beuger V; Stanley LA; Rode A; Wolf CR
    Mol Pharmacol; 2012 Jan; 81(1):63-72. PubMed ID: 21989258
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Chronic nicotine treatment induces rat CYP2D in the brain but not in the liver: an investigation of induction and time course.
    Yue J; Miksys S; Hoffmann E; Tyndale RF
    J Psychiatry Neurosci; 2008 Jan; 33(1):54-63. PubMed ID: 18197273
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.
    Corchero J; Granvil CP; Akiyama TE; Hayhurst GP; Pimprale S; Feigenbaum L; Idle JR; Gonzalez FJ
    Mol Pharmacol; 2001 Dec; 60(6):1260-7. PubMed ID: 11723233
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pinoline may be used as a probe for CYP2D6 activity.
    Jiang XL; Shen HW; Yu AM
    Drug Metab Dispos; 2009 Mar; 37(3):443-6. PubMed ID: 19095720
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes.
    Nakagawa Y; Suzuki T; Ishii H; Ogata A; Nakae D
    Chem Biol Interact; 2010 Dec; 188(3):393-403. PubMed ID: 20833158
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics.
    Shen HW; Wu C; Jiang XL; Yu AM
    Biochem Pharmacol; 2010 Jul; 80(1):122-8. PubMed ID: 20206139
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Difference in desipramine metabolic profile between wild-type and CYP2D6-humanized mice.
    Shen HW; Yu AM
    Drug Metab Lett; 2009 Dec; 3(4):234-41. PubMed ID: 19995332
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells.
    Mann A; Tyndale RF
    Eur J Neurosci; 2010 Apr; 31(7):1185-93. PubMed ID: 20345925
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.