These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
142 related articles for article (PubMed ID: 32779873)
1. Identification of three new compounds that directly target human serine hydroxymethyltransferase 2. Han Y; He L; Qi Y; Zhao Y; Pan Y; Fang B; Li S; Zhang JZH; Zhang L Chem Biol Drug Des; 2021 Feb; 97(2):221-230. PubMed ID: 32779873 [TBL] [Abstract][Full Text] [Related]
2. Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming. Paiardini A; Tramonti A; Schirch D; Guiducci G; di Salvo ML; Fiascarelli A; Giorgi A; Maras B; Cutruzzolà F; Contestabile R Biochim Biophys Acta; 2016 Nov; 1864(11):1506-17. PubMed ID: 27530298 [TBL] [Abstract][Full Text] [Related]
3. Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs. Scaletti E; Jemth AS; Helleday T; Stenmark P FEBS Lett; 2019 Jul; 593(14):1863-1873. PubMed ID: 31127856 [TBL] [Abstract][Full Text] [Related]
4. Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning. He L; Bao J; Yang Y; Dong S; Zhang L; Qi Y; Zhang JZH J Chem Inf Model; 2019 Sep; 59(9):3871-3878. PubMed ID: 31442042 [TBL] [Abstract][Full Text] [Related]
5. Cellular Pharmacodynamics of a Novel Pyrrolo[3,2- Dekhne AS; Ning C; Nayeen MJ; Shah K; Kalpage H; Frühauf J; Wallace-Povirk A; O'Connor C; Hou Z; Kim S; Hüttemann M; Gangjee A; Matherly LH Mol Pharmacol; 2020 Jan; 97(1):9-22. PubMed ID: 31707355 [TBL] [Abstract][Full Text] [Related]
6. Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties. Tramonti A; Nardella C; di Salvo ML; Barile A; Cutruzzolà F; Contestabile R Biochemistry; 2018 Dec; 57(51):6984-6996. PubMed ID: 30500180 [TBL] [Abstract][Full Text] [Related]
7. Cancer proteome and metabolite changes linked to SHMT2. Tong J; Krieger JR; Taylor P; Bagshaw R; Kang J; Jeedigunta S; Wybenga-Groot LE; Zhang W; Badr H; Mirhadi S; Pham NA; Coyaud É; Yu M; Li M; Cabanero M; Raught B; Maynes JT; Hawkins C; Tsao MS; Moran MF PLoS One; 2020; 15(9):e0237981. PubMed ID: 32903271 [TBL] [Abstract][Full Text] [Related]
8. Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Minton DR; Nam M; McLaughlin DJ; Shin J; Bayraktar EC; Alvarez SW; Sviderskiy VO; Papagiannakopoulos T; Sabatini DM; Birsoy K; Possemato R Mol Cell; 2018 Feb; 69(4):610-621.e5. PubMed ID: 29452640 [TBL] [Abstract][Full Text] [Related]
10. ERRα activates SHMT2 transcription to enhance the resistance of breast cancer to lapatinib via modulating the mitochondrial metabolic adaption. Li X; Zhang K; Hu Y; Luo N Biosci Rep; 2020 Jan; 40(1):. PubMed ID: 31894856 [TBL] [Abstract][Full Text] [Related]
11. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Wilke AC; Doebele C; Zindel A; Lee KS; Rieke SA; Ceribelli M; Comoglio F; Phelan JD; Wang JQ; Pikman Y; Jahn D; Häupl B; Schneider C; Scheich S; Tosto FA; Bohnenberger H; Stauder P; Schnütgen F; Slabicki M; Coulibaly ZA; Wolf S; Bojarczuk K; Chapuy B; Brandts CH; Stroebel P; Lewis CA; Engelke M; Xu X; Kim H; Dang TH; Schmitz R; Hodson DJ; Stegmaier K; Urlaub H; Serve H; Schmitt CA; Kreuz F; Knittel G; Rabinowitz JD; Reinhardt HC; Vander Heiden MG; Thomas C; Staudt LM; Zenz T; Oellerich T Blood; 2022 Jan; 139(4):538-553. PubMed ID: 34624079 [TBL] [Abstract][Full Text] [Related]
13. SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation. Yang X; Wang Z; Li X; Liu B; Liu M; Liu L; Chen S; Ren M; Wang Y; Yu M; Wang B; Zou J; Zhu WG; Yin Y; Gu W; Luo J Cancer Res; 2018 Jan; 78(2):372-386. PubMed ID: 29180469 [TBL] [Abstract][Full Text] [Related]
14. Metformin Is a Pyridoxal-5'-phosphate (PLP)-Competitive Inhibitor of SHMT2. Tramonti A; Cuyàs E; Encinar JA; Pietzke M; Paone A; Verdura S; Arbusà A; Martin-Castillo B; Giardina G; Joven J; Vazquez A; Contestabile R; Cutruzzolà F; Menendez JA Cancers (Basel); 2021 Aug; 13(16):. PubMed ID: 34439169 [TBL] [Abstract][Full Text] [Related]
15. A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells. Marani M; Paone A; Fiascarelli A; Macone A; Gargano M; Rinaldo S; Giardina G; Pontecorvi V; Koes D; McDermott L; Yang T; Paiardini A; Contestabile R; Cutruzzolà F Oncotarget; 2016 Jan; 7(4):4570-83. PubMed ID: 26717037 [TBL] [Abstract][Full Text] [Related]
16. SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT. Huo FC; Xie M; Zhu ZM; Zheng JN; Pei DS Genomics; 2022 Jul; 114(4):110424. PubMed ID: 35798250 [TBL] [Abstract][Full Text] [Related]
17. The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation. Choi YJ; Lee G; Yun SH; Lee W; Yu J; Kim SK; Lee BH Amino Acids; 2022 May; 54(5):823-834. PubMed ID: 35212811 [TBL] [Abstract][Full Text] [Related]
18. Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming. Liu Z; Fan M; Hou J; Pan S; Xu Y; Zhang H; Liu C; Hao X; Li X; Wang H Cell Death Dis; 2023 Feb; 14(2):144. PubMed ID: 36806313 [TBL] [Abstract][Full Text] [Related]
19. Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis. Zeng Y; Zhang J; Xu M; Chen F; Zi R; Yue J; Zhang Y; Chen N; Chin YE J Cancer; 2021; 12(19):5888-5894. PubMed ID: 34476002 [TBL] [Abstract][Full Text] [Related]
20. The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Parsa S; Ortega-Molina A; Ying HY; Jiang M; Teater M; Wang J; Zhao C; Reznik E; Pasion JP; Kuo D; Mohan P; Wang S; Camarillo JM; Thomas PM; Jain N; Garcia-Bermudez J; Cho BK; Tam W; Kelleher NL; Socci N; Dogan A; De Stanchina E; Ciriello G; Green MR; Li S; Birsoy K; Melnick AM; Wendel HG Nat Cancer; 2020; 1():653-664. PubMed ID: 33569544 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]