132 related articles for article (PubMed ID: 32787107)
1. Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
Mahy W; Patel M; Steadman D; Woodward HL; Atkinson BN; Svensson F; Willis NJ; Flint A; Papatheodorou D; Zhao Y; Vecchia L; Ruza RR; Hillier J; Frew S; Monaghan A; Costa A; Bictash M; Walter MW; Jones EY; Fish PV
J Med Chem; 2020 Sep; 63(17):9464-9483. PubMed ID: 32787107
[TBL] [Abstract][Full Text] [Related]
2. Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
Steadman D; Atkinson BN; Zhao Y; Willis NJ; Frew S; Monaghan A; Patel C; Armstrong E; Costelloe K; Magno L; Bictash M; Jones EY; Fish PV; Svensson F
J Med Chem; 2022 Jan; 65(1):562-578. PubMed ID: 34939789
[TBL] [Abstract][Full Text] [Related]
3. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
Willis NJ; Mahy W; Sipthorp J; Zhao Y; Woodward HL; Atkinson BN; Bayle ED; Svensson F; Frew S; Jeganathan F; Monaghan A; Benvegnù S; Jolly S; Vecchia L; Ruza RR; Kjær S; Howell S; Snijders AP; Bictash M; Salinas PC; Vincent JP; Jones EY; Whiting P; Fish PV
J Med Chem; 2022 May; 65(10):7212-7230. PubMed ID: 35536179
[TBL] [Abstract][Full Text] [Related]
4. Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
Bayle ED; Svensson F; Atkinson BN; Steadman D; Willis NJ; Woodward HL; Whiting P; Vincent JP; Fish PV
J Med Chem; 2021 Apr; 64(8):4289-4311. PubMed ID: 33783220
[TBL] [Abstract][Full Text] [Related]
5. Small-molecule inhibitors of carboxylesterase Notum.
Zhao Y; Jolly S; Benvegnu S; Jones EY; Fish PV
Future Med Chem; 2021 Jun; 13(11):1001-1015. PubMed ID: 33882714
[TBL] [Abstract][Full Text] [Related]
6. Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum.
Zhao Y; Ren J; Hillier J; Jones M; Lu W; Jones EY
J Pineal Res; 2020 Mar; 68(2):e12630. PubMed ID: 31876313
[TBL] [Abstract][Full Text] [Related]
7. Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Atkinson BN; Steadman D; Zhao Y; Sipthorp J; Vecchia L; Ruza RR; Jeganathan F; Lines G; Frew S; Monaghan A; Kjær S; Bictash M; Jones EY; Fish PV
Medchemcomm; 2019 Aug; 10(8):1361-1369. PubMed ID: 31534655
[TBL] [Abstract][Full Text] [Related]
8. 5-Phenyl-1,3,4-oxadiazol-2(3
Mahy W; Willis NJ; Zhao Y; Woodward HL; Svensson F; Sipthorp J; Vecchia L; Ruza RR; Hillier J; Kjær S; Frew S; Monaghan A; Bictash M; Salinas PC; Whiting P; Vincent JP; Jones EY; Fish PV
J Med Chem; 2020 Nov; 63(21):12942-12956. PubMed ID: 33124429
[TBL] [Abstract][Full Text] [Related]
9. Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Atkinson BN; Willis NJ; Zhao Y; Patel C; Frew S; Costelloe K; Magno L; Svensson F; Jones EY; Fish PV
Eur J Med Chem; 2023 May; 251():115132. PubMed ID: 36934521
[TBL] [Abstract][Full Text] [Related]
10. Structural Analysis and Development of Notum Fragment Screening Hits.
Zhao Y; Mahy W; Willis NJ; Woodward HL; Steadman D; Bayle ED; Atkinson BN; Sipthorp J; Vecchia L; Ruza RR; Harlos K; Jeganathan F; Constantinou S; Costa A; Kjær S; Bictash M; Salinas PC; Whiting P; Vincent JP; Fish PV; Jones EY
ACS Chem Neurosci; 2022 Jul; 13(13):2060-2077. PubMed ID: 35731924
[TBL] [Abstract][Full Text] [Related]
11. Structural Insights into Notum Covalent Inhibition.
Zhao Y; Svensson F; Steadman D; Frew S; Monaghan A; Bictash M; Moreira T; Chalk R; Lu W; Fish PV; Jones EY
J Med Chem; 2021 Aug; 64(15):11354-11363. PubMed ID: 34292747
[TBL] [Abstract][Full Text] [Related]
12. Notum deacylates Wnt proteins to suppress signalling activity.
Kakugawa S; Langton PF; Zebisch M; Howell S; Chang TH; Liu Y; Feizi T; Bineva G; O'Reilly N; Snijders AP; Jones EY; Vincent JP
Nature; 2015 Mar; 519(7542):187-192. PubMed ID: 25731175
[TBL] [Abstract][Full Text] [Related]
13. Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Atkinson BN; Steadman D; Mahy W; Zhao Y; Sipthorp J; Bayle ED; Svensson F; Papageorgiou G; Jeganathan F; Frew S; Monaghan A; Bictash M; Jones EY; Fish PV
Bioorg Med Chem Lett; 2020 Feb; 30(3):126751. PubMed ID: 31862412
[TBL] [Abstract][Full Text] [Related]
14. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade.
Wang Y; Jiang Y; Ding S; Li J; Song N; Ren Y; Hong D; Wu C; Li B; Wang F; He W; Wang J; Mei Z
Cell Res; 2018 Dec; 28(12):1186-1194. PubMed ID: 30254335
[TBL] [Abstract][Full Text] [Related]
15. Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3.
Harikrishnan LS; Kamau MG; Wan H; Inghrim JA; Zimmermann K; Sang X; Mastalerz HA; Johnson WL; Zhang G; Lombardo LJ; Poss MA; Trainor GL; Tokarski JS; Lorenzi MV; You D; Gottardis MM; Baldwin KF; Lippy J; Nirschl DS; Qiu R; Miller AV; Khan J; Sack JS; Purandare AV
Bioorg Med Chem Lett; 2011 Mar; 21(5):1425-8. PubMed ID: 21282055
[TBL] [Abstract][Full Text] [Related]
16. An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.
Willis NJ; Bayle ED; Papageorgiou G; Steadman D; Atkinson BN; Mahy W; Fish PV
Beilstein J Org Chem; 2019; 15():2790-2797. PubMed ID: 31807213
[No Abstract] [Full Text] [Related]
17. Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
Yoon KJ; Hyatt JL; Morton CL; Lee RE; Potter PM; Danks MK
Mol Cancer Ther; 2004 Aug; 3(8):903-9. PubMed ID: 15299073
[TBL] [Abstract][Full Text] [Related]
18.
Tian Y; Wang X; Cramer Z; Rhoades J; Estep KN; Ma X; Adams-Tzivelekidis S; Katona BW; Johnson FB; Yu Z; Blanco MA; Lengner CJ; Li N
Gut; 2023 Nov; 72(12):2294-2306. PubMed ID: 37591698
[TBL] [Abstract][Full Text] [Related]
19. Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1.
Zhang J; Pan QS; Qian XK; Zhou XL; Wang YJ; He RJ; Wang LT; Li YR; Huo H; Sun CG; Sun L; Zou LW; Yang L
J Enzyme Inhib Med Chem; 2022 Dec; 37(1):629-640. PubMed ID: 35100926
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors.
Rochais C; Lescot E; Lisowski V; Lepailleur A; Santos JS; Bureau R; Dallemagne P; Meijer L; Rault S
J Enzyme Inhib Med Chem; 2004 Dec; 19(6):585-93. PubMed ID: 15662962
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]