117 related articles for article (PubMed ID: 32799625)
1. The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells.
Okamoto S; Miyano K; Kajikawa M; Yamauchi A; Kuribayashi F
Biosci Biotechnol Biochem; 2020 Nov; 84(11):2319-2326. PubMed ID: 32799625
[TBL] [Abstract][Full Text] [Related]
2. rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.
Negi SS; Brown P
Oncotarget; 2015 Jul; 6(20):18094-104. PubMed ID: 26061708
[TBL] [Abstract][Full Text] [Related]
3. Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.
Drygin D; Lin A; Bliesath J; Ho CB; O'Brien SE; Proffitt C; Omori M; Haddach M; Schwaebe MK; Siddiqui-Jain A; Streiner N; Quin JE; Sanij E; Bywater MJ; Hannan RD; Ryckman D; Anderes K; Rice WG
Cancer Res; 2011 Feb; 71(4):1418-30. PubMed ID: 21159662
[TBL] [Abstract][Full Text] [Related]
4. CX-5461-loaded nucleolus-targeting nanoplatform for cancer therapy through induction of pro-death autophagy.
Duo Y; Yang M; Du Z; Feng C; Xing C; Wu Y; Xie Z; Zhang F; Huang L; Zeng X; Chen H
Acta Biomater; 2018 Oct; 79():317-330. PubMed ID: 30172068
[TBL] [Abstract][Full Text] [Related]
5. Transient rRNA synthesis inhibition with CX-5461 is sufficient to elicit growth arrest and cell death in acute lymphoblastic leukemia cells.
Negi SS; Brown P
Oncotarget; 2015 Oct; 6(33):34846-58. PubMed ID: 26472108
[TBL] [Abstract][Full Text] [Related]
6. PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway.
Chen H; Duo Y; Hu B; Wang Z; Zhang F; Tsai H; Zhang J; Zhou L; Wang L; Wang X; Huang L
Oncotarget; 2016 Nov; 7(48):78747-78763. PubMed ID: 27729611
[TBL] [Abstract][Full Text] [Related]
7. The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.
Rebello RJ; Kusnadi E; Cameron DP; Pearson HB; Lesmana A; Devlin JR; Drygin D; Clark AK; Porter L; Pedersen J; Sandhu S; Risbridger GP; Pearson RB; Hannan RD; Furic L
Clin Cancer Res; 2016 Nov; 22(22):5539-5552. PubMed ID: 27486174
[TBL] [Abstract][Full Text] [Related]
8. Autophagy Induced by CX-4945, a Casein Kinase 2 Inhibitor, Enhances Apoptosis in Pancreatic Cancer Cell Lines.
Hwang DW; So KS; Kim SC; Park KM; Lee YJ; Kim SW; Choi CM; Rho JK; Choi YJ; Lee JC
Pancreas; 2017 Apr; 46(4):575-581. PubMed ID: 28196025
[TBL] [Abstract][Full Text] [Related]
9. p53 induces a survival transcriptional response after nucleolar stress.
Liao H; Gaur A; Mauvais C; Denicourt C
Mol Biol Cell; 2021 Oct; 32(20):ar3. PubMed ID: 34319761
[TBL] [Abstract][Full Text] [Related]
10. Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB.
Buontempo F; Orsini E; Lonetti A; Cappellini A; Chiarini F; Evangelisti C; Evangelisti C; Melchionda F; Pession A; Bertaina A; Locatelli F; Bertacchini J; Neri LM; McCubrey JA; Martelli AM
Oncotarget; 2016 Jan; 7(2):1323-40. PubMed ID: 26593250
[TBL] [Abstract][Full Text] [Related]
11. Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells.
Wang F; Li H; Yan XG; Zhou ZW; Yi ZG; He ZX; Pan ST; Yang YX; Wang ZZ; Zhang X; Yang T; Qiu JX; Zhou SF
Drug Des Devel Ther; 2015; 9():575-601. PubMed ID: 25632225
[TBL] [Abstract][Full Text] [Related]
12. CX-5461 Enhances the Efficacy of APR-246 via Induction of DNA Damage and Replication Stress in Triple-Negative Breast Cancer.
Makhale A; Nanayakkara D; Raninga P; Khanna KK; Kalimutho M
Int J Mol Sci; 2021 May; 22(11):. PubMed ID: 34071360
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Quin J; Chan KT; Devlin JR; Cameron DP; Diesch J; Cullinane C; Ahern J; Khot A; Hein N; George AJ; Hannan KM; Poortinga G; Sheppard KE; Khanna KK; Johnstone RW; Drygin D; McArthur GA; Pearson RB; Sanij E; Hannan RD
Oncotarget; 2016 Aug; 7(31):49800-49818. PubMed ID: 27391441
[TBL] [Abstract][Full Text] [Related]
14. The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.
Bruno PM; Lu M; Dennis KA; Inam H; Moore CJ; Sheehe J; Elledge SJ; Hemann MT; Pritchard JR
Proc Natl Acad Sci U S A; 2020 Feb; 117(8):4053-4060. PubMed ID: 32041867
[TBL] [Abstract][Full Text] [Related]
15. In vitro anticancer effects of esculetin against human leukemia cell lines involves apoptotic cell death, autophagy, G0/G1 cell cycle arrest and modulation of Raf/MEK/ERK signalling pathway.
Wang X; Yang C; Zhang Q; Wang C; Zhou X; Zhang X; Liu S
J BUON; 2019; 24(4):1686-1691. PubMed ID: 31646826
[TBL] [Abstract][Full Text] [Related]
16. Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma.
Wang X; Shen C; Liu Z; Peng F; Chen X; Yang G; Zhang D; Yin Z; Ma J; Zheng Z; Zhao B; Liu H; Wang L; Wu J; Han D; Wang K; Zhong C; Hou X; Zhao W; Shu M; Wang X; Zhao S
Cell Death Dis; 2018 Oct; 9(10):1032. PubMed ID: 30302016
[TBL] [Abstract][Full Text] [Related]
17. Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461.
Li G; Shen J; Cao J; Zhou G; Lei T; Sun Y; Gao H; Ding Y; Xu W; Zhan Z; Chen Y; Huang H
J Exp Clin Cancer Res; 2018 Apr; 37(1):78. PubMed ID: 29631594
[TBL] [Abstract][Full Text] [Related]
18. RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.
Lee HC; Wang H; Baladandayuthapani V; Lin H; He J; Jones RJ; Kuiatse I; Gu D; Wang Z; Ma W; Lim J; O'Brien S; Keats J; Yang J; Davis RE; Orlowski RZ
Br J Haematol; 2017 Apr; 177(1):80-94. PubMed ID: 28369725
[TBL] [Abstract][Full Text] [Related]
19. Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression.
Okamoto S; Tsujioka T; Suemori S; Kida J; Kondo T; Tohyama Y; Tohyama K
Cancer Sci; 2016 Sep; 107(9):1302-14. PubMed ID: 27311589
[TBL] [Abstract][Full Text] [Related]
20. Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells.
Zhong W; Tang X; Liu Y; Zhou C; Liu P; Li E; Zhong P; Lv H; Zou Q; Wang M
Molecules; 2020 Feb; 25(4):. PubMed ID: 32098126
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]