These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
184 related articles for article (PubMed ID: 32810476)
41. A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. Summerfield RL; Daigle DM; Mayer S; Mallik D; Hughes DW; Jackson SG; Sulek M; Organ MG; Brown ED; Junop MS J Med Chem; 2006 Nov; 49(24):6977-86. PubMed ID: 17125251 [TBL] [Abstract][Full Text] [Related]
42. Trimethoprim: An Old Antibacterial Drug as a Template to Search for New Targets. Synthesis, Biological Activity and Molecular Modeling Study of Novel Trimethoprim Analogs. Wróbel A; Maliszewski D; Baradyn M; Drozdowska D Molecules; 2019 Dec; 25(1):. PubMed ID: 31892256 [TBL] [Abstract][Full Text] [Related]
43. Reduced susceptibility of Moritella profunda dihydrofolate reductase to trimethoprim is not due to glutamate 28. Loveridge EJ; Dawson WM; Evans RM; Sobolewska A; Allemann RK Protein J; 2011 Dec; 30(8):546-8. PubMed ID: 21968646 [TBL] [Abstract][Full Text] [Related]
44. Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain. Chan DC; Fu H; Forsch RA; Queener SF; Rosowsky A J Med Chem; 2005 Jun; 48(13):4420-31. PubMed ID: 15974594 [TBL] [Abstract][Full Text] [Related]
47. Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building. Lemcke T; Christensen IT; Jørgensen FS Bioorg Med Chem; 1999 Jun; 7(6):1003-11. PubMed ID: 10428368 [TBL] [Abstract][Full Text] [Related]
49. Kinetics of the inhibition of bovine liver dihydrofolate reductase by tea catechins: origin of slow-binding inhibition and pH studies. Navarro-Perán E; Cabezas-Herrera J; Hiner AN; Sadunishvili T; García-Cánovas F; Rodríguez-López JN Biochemistry; 2005 May; 44(20):7512-25. PubMed ID: 15895994 [TBL] [Abstract][Full Text] [Related]
50. Selectivity analysis of 5-(arylthio)-2,4-diaminoquinazolines as inhibitors of Candida albicans dihydrofolate reductase by molecular dynamics simulations. Gokhale VM; Kulkarni VM J Comput Aided Mol Des; 2000 Jul; 14(5):495-506. PubMed ID: 10896321 [TBL] [Abstract][Full Text] [Related]
51. The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling. Hong W; Wang Y; Chang Z; Yang Y; Pu J; Sun T; Kaur S; Sacchettini JC; Jung H; Lin Wong W; Fah Yap L; Fong Ngeow Y; Paterson IC; Wang H Sci Rep; 2015 Oct; 5():15328. PubMed ID: 26471125 [TBL] [Abstract][Full Text] [Related]
52. A molecular model of the folate binding site of Pneumocystis carinii dihydrofolate reductase. Southerland WM J Comput Aided Mol Des; 1994 Apr; 8(2):113-22. PubMed ID: 8064329 [TBL] [Abstract][Full Text] [Related]
53. Structural comparison of chromosomal and exogenous dihydrofolate reductase from Staphylococcus aureus in complex with the potent inhibitor trimethoprim. Heaslet H; Harris M; Fahnoe K; Sarver R; Putz H; Chang J; Subramanyam C; Barreiro G; Miller JR Proteins; 2009 Aug; 76(3):706-17. PubMed ID: 19280600 [TBL] [Abstract][Full Text] [Related]
54. Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques. Vickers AA; Potter NJ; Fishwick CW; Chopra I; O'Neill AJ J Antimicrob Chemother; 2009 Jun; 63(6):1112-7. PubMed ID: 19383727 [TBL] [Abstract][Full Text] [Related]
55. Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium. Forsch RA; Queener SF; Rosowsky A Bioorg Med Chem Lett; 2004 Apr; 14(7):1811-5. PubMed ID: 15026078 [TBL] [Abstract][Full Text] [Related]
56. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Cody V; Pace J; Chisum K; Rosowsky A Proteins; 2006 Dec; 65(4):959-69. PubMed ID: 17019704 [TBL] [Abstract][Full Text] [Related]
57. Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase. Strader MB; Smiley RD; Stinnett LG; VerBerkmoes NC; Howell EE Biochemistry; 2001 Sep; 40(38):11344-52. PubMed ID: 11560482 [TBL] [Abstract][Full Text] [Related]
58. Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity. Paulsen JL; Bendel SD; Anderson AC Chem Biol Drug Des; 2011 Oct; 78(4):505-12. PubMed ID: 21726415 [TBL] [Abstract][Full Text] [Related]