BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

436 related articles for article (PubMed ID: 32846158)

  • 1. Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling.
    Zhang JZ; Lu TW; Stolerman LM; Tenner B; Yang JR; Zhang JF; Falcke M; Rangamani P; Taylor SS; Mehta S; Zhang J
    Cell; 2020 Sep; 182(6):1531-1544.e15. PubMed ID: 32846158
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
    Lu TW; Aoto PC; Weng JH; Nielsen C; Cash JN; Hall J; Zhang P; Simon SM; Cianfrocco MA; Taylor SS
    PLoS Biol; 2020 Dec; 18(12):e3001018. PubMed ID: 33370777
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.
    Cazabat L; Ragazzon B; Varin A; Potier-Cartereau M; Vandier C; Vezzosi D; Risk-Rabin M; Guellich A; Schittl J; Lechêne P; Richter W; Nikolaev VO; Zhang J; Bertherat J; Vandecasteele G
    Hum Mol Genet; 2014 Mar; 23(5):1163-74. PubMed ID: 24122441
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα.
    Akimoto M; McNicholl ET; Ramkissoon A; Moleschi K; Taylor SS; Melacini G
    PLoS Biol; 2015; 13(11):e1002305. PubMed ID: 26618408
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Adenylate control in cAMP signaling: implications for adaptation in signalosomes.
    Tulsian NK; Ghode A; Anand GS
    Biochem J; 2020 Aug; 477(16):2981-2998. PubMed ID: 32722762
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular Determinants and Signaling Effects of PKA RIα Phase Separation.
    Hardy JC; Pool EH; Bruystens JGH; Zhou X; Li Q; Zhou DR; Palay M; Tan G; Chen L; Choi JLC; Lee HN; Strack S; Wang D; Taylor SS; Mehta S; Zhang J
    bioRxiv; 2023 Dec; ():. PubMed ID: 38168176
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.
    Krishnamurthy S; Moorthy BS; Xin Xiang L; Xin Shan L; Bharatham K; Tulsian NK; Mihalek I; Anand GS
    Biophys J; 2014 Sep; 107(6):1426-40. PubMed ID: 25229150
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
    Nesterova MV; Cho-Chung YS
    Clin Cancer Res; 2004 Jul; 10(13):4568-77. PubMed ID: 15240549
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα.
    Haushalter KJ; Schilling JM; Song Y; Sastri M; Perkins GA; Strack S; Taylor SS; Patel HH
    Am J Physiol Heart Circ Physiol; 2019 Dec; 317(6):H1231-H1242. PubMed ID: 31674811
    [TBL] [Abstract][Full Text] [Related]  

  • 10. CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma.
    Engelholm LH; Riaz A; Serra D; Dagnæs-Hansen F; Johansen JV; Santoni-Rugiu E; Hansen SH; Niola F; Frödin M
    Gastroenterology; 2017 Dec; 153(6):1662-1673.e10. PubMed ID: 28923495
    [TBL] [Abstract][Full Text] [Related]  

  • 11. N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo.
    Wolter S; Dove S; Golombek M; Schwede F; Seifert R
    Naunyn Schmiedebergs Arch Pharmacol; 2014 Dec; 387(12):1163-75. PubMed ID: 25192685
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells.
    Naviglio S; Di Gesto D; Illiano F; Chiosi E; Giordano A; Illiano G; Spina A
    J Cell Physiol; 2010 Nov; 225(3):801-9. PubMed ID: 20589829
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells.
    Haushalter KJ; Casteel DE; Raffeiner A; Stefan E; Patel HH; Taylor SS
    J Biol Chem; 2018 Mar; 293(12):4411-4421. PubMed ID: 29378851
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Chemoprevention with protein kinase A RIalpha antisense in DMBA-mammary carcinogenesis.
    Nesterova MV; Cho-Chung YS
    Ann N Y Acad Sci; 2005 Nov; 1058():255-64. PubMed ID: 16394142
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP.
    Wu J; Jones JM; Nguyen-Huu X; Ten Eyck LF; Taylor SS
    Biochemistry; 2004 Jun; 43(21):6620-9. PubMed ID: 15157095
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Localization of cAMP-dependent signal transducers in early rat liver carcinogenesis.
    Skarpen E; Thoresen GH; Taskén K; Samuelsen JT; Jahnsen T; Schwarze PE; Huitfeldt HS
    Histochem Cell Biol; 1998 Mar; 109(3):203-9. PubMed ID: 9541468
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.
    Lorenz R; Moon EW; Kim JJ; Schmidt SH; Sankaran B; Pavlidis IV; Kim C; Herberg FW
    Biochem J; 2017 Jul; 474(14):2389-2403. PubMed ID: 28583991
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278).
    Yang WL; Ravatn R; Kudoh K; Alabanza L; Chin KV
    Biochem Biophys Res Commun; 2010 Jan; 391(3):1318-23. PubMed ID: 20026299
    [TBL] [Abstract][Full Text] [Related]  

  • 19. BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
    Hirsch TZ; Negulescu A; Gupta B; Caruso S; Noblet B; Couchy G; Bayard Q; Meunier L; Morcrette G; Scoazec JY; Blanc JF; Amaddeo G; Nault JC; Bioulac-Sage P; Ziol M; Beaufrère A; Paradis V; Calderaro J; Imbeaud S; Zucman-Rossi J
    J Hepatol; 2020 May; 72(5):924-936. PubMed ID: 31862487
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The differential response of protein kinase A to cyclic AMP in discrete brain areas correlates with the abundance of regulatory subunit II.
    Ventra C; Porcellini A; Feliciello A; Gallo A; Paolillo M; Mele E; Avvedimento VE; Schettini G
    J Neurochem; 1996 Apr; 66(4):1752-61. PubMed ID: 8627334
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.