BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

177 related articles for article (PubMed ID: 32861662)

  • 1. Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases.
    Covington M; He X; Scuron M; Li J; Collins R; Juvekar A; Shin N; Favata M; Gallagher K; Sarah S; Xue CB; Peel M; Burke K; Oliver J; Fay B; Yao W; Huang T; Scherle P; Diamond S; Newton R; Zhang Y; Smith P
    Eur J Pharmacol; 2020 Oct; 885():173505. PubMed ID: 32861662
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Itacitinib (INCB039110), a JAK1 Inhibitor, Reduces Cytokines Associated with Cytokine Release Syndrome Induced by CAR T-cell Therapy.
    Huarte E; O'Connor RS; Peel MT; Nunez-Cruz S; Leferovich J; Juvekar A; Yang YO; Truong L; Huang T; Naim A; Milone MC; Smith PA
    Clin Cancer Res; 2020 Dec; 26(23):6299-6309. PubMed ID: 32998963
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions.
    Fetter T; Smith P; Guel T; Braegelmann C; Bieber T; Wenzel J
    Front Immunol; 2020; 11():344. PubMed ID: 32194562
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050.
    Fridman JS; Scherle PA; Collins R; Burn TC; Li Y; Li J; Covington MB; Thomas B; Collier P; Favata MF; Wen X; Shi J; McGee R; Haley PJ; Shepard S; Rodgers JD; Yeleswaram S; Hollis G; Newton RC; Metcalf B; Friedman SM; Vaddi K
    J Immunol; 2010 May; 184(9):5298-307. PubMed ID: 20363976
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Differential effects of itacitinib, fedratinib, and ruxolitinib in mouse models of hemophagocytic lymphohistiocytosis.
    Keenan C; Albeituni S; Oak N; Stroh A; Tillman HS; Wang Y; Freeman BB; Alemán-Arteaga S; Meyer LK; Woods R; Verbist KC; Zhou Y; Cheng C; Nichols KE
    Blood; 2024 Jun; 143(23):2386-2400. PubMed ID: 38446698
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata.
    Dai Z; Chen J; Chang Y; Christiano AM
    JCI Insight; 2021 Apr; 6(7):. PubMed ID: 33830087
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis.
    Mascarenhas JO; Talpaz M; Gupta V; Foltz LM; Savona MR; Paquette R; Turner AR; Coughlin P; Winton E; Burn TC; O'Neill P; Clark J; Hunter D; Assad A; Hoffman R; Verstovsek S
    Haematologica; 2017 Feb; 102(2):327-335. PubMed ID: 27789678
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease.
    Schroeder MA; Khoury HJ; Jagasia M; Ali H; Schiller GJ; Staser K; Choi J; Gehrs L; Arbushites MC; Yan Y; Langmuir P; Srinivas N; Pratta M; Perales MA; Chen YB; Meyers G; DiPersio JF
    Blood Adv; 2020 Apr; 4(8):1656-1669. PubMed ID: 32324888
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Therapeutic treatment of a novel selective JAK3/JAK1/TBK1 inhibitor, CS12192, in rat and mouse models of rheumatoid arthritis.
    Shan S; Zhou Y; Yu J; Yang Q; Pan D; Wang Y; Li L; Zhu J; Zhang Y; Huang S; Li Z; Ning Z; Xin L; Lu X
    Int Immunopharmacol; 2019 Dec; 77():105914. PubMed ID: 31634789
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacologic Inhibition of JAK1/JAK2 Signaling Reduces Experimental Murine Acute GVHD While Preserving GVT Effects.
    Carniti C; Gimondi S; Vendramin A; Recordati C; Confalonieri D; Bermema A; Corradini P; Mariotti J
    Clin Cancer Res; 2015 Aug; 21(16):3740-9. PubMed ID: 25977345
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Impact on creatinine renal clearance by the interplay of multiple renal transporters: a case study with INCB039110.
    Zhang Y; Warren MS; Zhang X; Diamond S; Williams B; Punwani N; Huang J; Huang Y; Yeleswaram S
    Drug Metab Dispos; 2015 Apr; 43(4):485-9. PubMed ID: 25605813
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
    Van Rompaey L; Galien R; van der Aar EM; Clement-Lacroix P; Nelles L; Smets B; Lepescheux L; Christophe T; Conrath K; Vandeghinste N; Vayssiere B; De Vos S; Fletcher S; Brys R; van 't Klooster G; Feyen JH; Menet C
    J Immunol; 2013 Oct; 191(7):3568-77. PubMed ID: 24006460
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function.
    De Vries LCS; Duarte JM; De Krijger M; Welting O; Van Hamersveld PHP; Van Leeuwen-Hilbers FWM; Moerland PD; Jongejan A; D'Haens GR; De Jonge WJ; Wildenberg ME
    Inflamm Bowel Dis; 2019 Mar; 25(4):647-660. PubMed ID: 30668755
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evaluation of Clinical Cardiac Safety of Itacitinib, a JAK1 Inhibitor, in Healthy Participants.
    Gong X; Darpo B; Xue H; Punwani N; He K; Barbour AM; Epstein N; Landman R; Chen X; Yeleswaram S
    Clin Pharmacol Drug Dev; 2020 Aug; 9(6):677-688. PubMed ID: 31821750
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ruxolitinib, a JAK1/JAK2 selective inhibitor, ameliorates acute and chronic steroid-refractory GvHD mouse models.
    Huarte E; Peel M; Juvekar A; Dubé P; Sarah S; Stephens L; Stewart B; Long B; Czerniak P; Oliver J; Smith P
    Immunotherapy; 2021 Aug; 13(12):977-987. PubMed ID: 34184542
    [No Abstract]   [Full Text] [Related]  

  • 16. A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis.
    Bissonnette R; Luchi M; Fidelus-Gort R; Jackson S; Zhang H; Flores R; Newton R; Scherle P; Yeleswaram S; Chen X; Menter A
    J Dermatolog Treat; 2016 Aug; 27(4):332-8. PubMed ID: 26769332
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Novel JAK Inhibitors to Reduce Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation in a Preclinical Mouse Model.
    Kim S; Ruminski P; Singh M; Staser K; Ashami K; Ritchey J; Lim S; DiPersio JF; Choi J
    Molecules; 2024 Apr; 29(8):. PubMed ID: 38675621
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phase 1 study of the PI3Kδ inhibitor INCB040093 ± JAK1 inhibitor itacitinib in relapsed/refractory B-cell lymphoma.
    Phillips TJ; Forero-Torres A; Sher T; Diefenbach CS; Johnston P; Talpaz M; Pulini J; Zhou L; Scherle P; Chen X; Barr PM
    Blood; 2018 Jul; 132(3):293-306. PubMed ID: 29695516
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A biomarker signature to predict complete response to itacitinib and corticosteroids in acute graft-versus-host disease.
    Pratta M; Paczesny S; Socie G; Barkey N; Liu H; Owens S; Arbushites MC; Schroeder MA; Howell MD
    Br J Haematol; 2022 Aug; 198(4):729-739. PubMed ID: 35689489
    [TBL] [Abstract][Full Text] [Related]  

  • 20. JAK1-STAT3 blockade by JAK inhibitor SHR0302 attenuates inflammatory responses of adjuvant-induced arthritis rats and decreases Th17 and total B cells.
    Wu H; Yan S; Chen J; Luo X; Li P; Jia X; Dai X; Wang C; Huang Q; Liu L; Zhang Y; Zhou A; Chang Y; Zhang L; Wei W
    Joint Bone Spine; 2016 Oct; 83(5):525-32. PubMed ID: 26832189
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.