BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

210 related articles for article (PubMed ID: 32873592)

  • 1. Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1.
    Squirewell EJ; Mareus R; Horne LP; Stacpoole PW; James MO
    Drug Metab Dispos; 2020 Nov; 48(11):1224-1230. PubMed ID: 32873592
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.
    Squirewell EJ; Smeltz MG; Rowland-Faux L; Horne LP; Stacpoole PW; James MO
    Drug Metab Dispos; 2020 Nov; 48(11):1217-1223. PubMed ID: 32873593
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver.
    Smeltz MG; Hu Z; Zhong G; Jahn SC; Rowland-Faux L; Horne LP; Stacpoole PW; James MO
    Chem Res Toxicol; 2019 Oct; 32(10):2042-2052. PubMed ID: 31524376
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases.
    Lim CE; Matthaei KI; Blackburn AC; Davis RP; Dahlstrom JE; Koina ME; Anders MW; Board PG
    Am J Pathol; 2004 Aug; 165(2):679-93. PubMed ID: 15277241
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
    James MO; Jahn SC; Zhong G; Smeltz MG; Hu Z; Stacpoole PW
    Pharmacol Ther; 2017 Feb; 170():166-180. PubMed ID: 27771434
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
    Guo X; Dixit V; Liu H; Shroads AL; Henderson GN; James MO; Stacpoole PW
    Drug Metab Dispos; 2006 Jan; 34(1):36-42. PubMed ID: 16199472
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1.
    Li W; James MO; McKenzie SC; Calcutt NA; Liu C; Stacpoole PW
    J Pharmacol Exp Ther; 2011 Jan; 336(1):87-94. PubMed ID: 20884751
    [TBL] [Abstract][Full Text] [Related]  

  • 8.
    Tian DD; Bennett SK; Coupland LA; Forwood K; Lwin Y; Pooryousef N; Tea I; Truong TT; Neeman T; Crispin P; D'Rozario J; Blackburn AC
    Pharmacol Res Perspect; 2019 Dec; 7(6):e00526. PubMed ID: 31624634
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.
    Blackburn AC; Matthaei KI; Lim C; Taylor MC; Cappello JY; Hayes JD; Anders MW; Board PG
    Mol Pharmacol; 2006 Feb; 69(2):650-7. PubMed ID: 16278372
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.
    Shroads AL; Coats BS; McDonough CW; Langaee T; Stacpoole PW
    J Clin Pharmacol; 2015 Jan; 55(1):50-5. PubMed ID: 25079374
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
    Li W; Gu Y; James MO; Hines RN; Simpson P; Langaee T; Stacpoole PW
    Drug Metab Dispos; 2012 Feb; 40(2):232-9. PubMed ID: 22028318
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.
    Jahn SC; Smeltz MG; Hu Z; Rowland-Faux L; Zhong G; Lorenzo RJ; Cisneros KV; Stacpoole PW; James MO
    Biochem Pharmacol; 2018 Jun; 152():236-243. PubMed ID: 29626439
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.
    Mangal N; James MO; Stacpoole PW; Schmidt S
    J Clin Pharmacol; 2018 Feb; 58(2):212-220. PubMed ID: 28914978
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.
    Zhong G; Li W; Gu Y; Langaee T; Stacpoole PW; James MO
    Chem Biol Interact; 2014 May; 215():33-9. PubMed ID: 24632415
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor.
    Schultz IR; Merdink JL; Gonzalez-Leon A; Bull RJ
    Toxicology; 2002 May; 173(3):229-47. PubMed ID: 11960676
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
    Zhong G; James MO; Smeltz MG; Jahn SC; Langaee T; Simpson P; Stacpoole PW
    Drug Metab Dispos; 2018 Aug; 46(8):1118-1128. PubMed ID: 29853471
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.
    Theodoratos A; Blackburn AC; Cappello J; Tummala P; Dahlstrom JE; Board PG
    Biochem Pharmacol; 2012 Feb; 83(3):427-33. PubMed ID: 22127296
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.
    Shroads AL; Coats BS; Langaee T; Shuster JJ; Stacpoole PW
    Drug Metab Pers Ther; 2015 Mar; 30(1):49-55. PubMed ID: 25283137
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.
    Anderson WB; Board PG; Anders MW
    Chem Res Toxicol; 2004 May; 17(5):650-62. PubMed ID: 15144222
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pharmacogenetic considerations with dichloroacetate dosing.
    James MO; Stacpoole PW
    Pharmacogenomics; 2016 May; 17(7):743-53. PubMed ID: 27143230
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.