BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 32878986)

  • 1. Structural basis for the interaction of Shiga toxin 2a with a C-terminal peptide of ribosomal P stalk proteins.
    Rudolph MJ; Davis SA; Tumer NE; Li XP
    J Biol Chem; 2020 Nov; 295(46):15588-15596. PubMed ID: 32878986
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction.
    Kulczyk AW; Sorzano COS; Grela P; Tchórzewski M; Tumer NE; Li XP
    J Biol Chem; 2023 Jan; 299(1):102795. PubMed ID: 36528064
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A fluorescence anisotropy-based competition assay to identify inhibitors against ricin and Shiga toxin ribosome interactions.
    Dutta A; Szekely Z; Guven H; Li XP; McLaughlin JE; Tumer NE
    Anal Biochem; 2024 Sep; 692():115580. PubMed ID: 38825159
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal Structure of Ribosome-Inactivating Protein Ricin A Chain in Complex with the C-Terminal Peptide of the Ribosomal Stalk Protein P2.
    Shi WW; Tang YS; Sze SY; Zhu ZN; Wong KB; Shaw PC
    Toxins (Basel); 2016 Oct; 8(10):. PubMed ID: 27754366
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Shiga toxin 1 is more dependent on the P proteins of the ribosomal stalk for depurination activity than Shiga toxin 2.
    Chiou JC; Li XP; Remacha M; Ballesta JP; Tumer NE
    Int J Biochem Cell Biol; 2011 Dec; 43(12):1792-801. PubMed ID: 21907821
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conserved Arginines at the P-Protein Stalk Binding Site and the Active Site Are Critical for Ribosome Interactions of Shiga Toxins but Do Not Contribute to Differences in the Affinity of the A1 Subunits for the Ribosome.
    Basu D; Kahn JN; Li XP; Tumer NE
    Infect Immun; 2016 Dec; 84(12):3290-3301. PubMed ID: 27600507
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural insights into the interaction of the ribosomal P stalk protein P2 with a type II ribosome-inactivating protein ricin.
    Fan X; Zhu Y; Wang C; Niu L; Teng M; Li X
    Sci Rep; 2016 Nov; 6():37803. PubMed ID: 27886256
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The A1 Subunit of Shiga Toxin 2 Has Higher Affinity for Ribosomes and Higher Catalytic Activity than the A1 Subunit of Shiga Toxin 1.
    Basu D; Li XP; Kahn JN; May KL; Kahn PC; Tumer NE
    Infect Immun; 2016 Jan; 84(1):149-61. PubMed ID: 26483409
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differences in Ribosome Binding and Sarcin/Ricin Loop Depurination by Shiga and Ricin Holotoxins.
    Li XP; Tumer NE
    Toxins (Basel); 2017 Apr; 9(4):. PubMed ID: 28398250
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structures of eukaryotic ribosomal stalk proteins and its complex with trichosanthin, and their implications in recruiting ribosome-inactivating proteins to the ribosomes.
    Choi AK; Wong EC; Lee KM; Wong KB
    Toxins (Basel); 2015 Feb; 7(3):638-47. PubMed ID: 25723321
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Charged and hydrophobic surfaces on the a chain of shiga-like toxin 1 recognize the C-terminal domain of ribosomal stalk proteins.
    McCluskey AJ; Bolewska-Pedyczak E; Jarvik N; Chen G; Sidhu SS; Gariépy J
    PLoS One; 2012; 7(2):e31191. PubMed ID: 22355345
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Single-domain antibodies neutralize ricin toxin intracellularly by blocking access to ribosomal P-stalk proteins.
    Czajka TF; Vance DJ; Davis S; Rudolph MJ; Mantis NJ
    J Biol Chem; 2022 Apr; 298(4):101742. PubMed ID: 35182523
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Interaction between trichosanthin, a ribosome-inactivating protein, and the ribosomal stalk protein P2 by chemical shift perturbation and mutagenesis analyses.
    Chan DS; Chu LO; Lee KM; Too PH; Ma KW; Sze KH; Zhu G; Shaw PC; Wong KB
    Nucleic Acids Res; 2007; 35(5):1660-72. PubMed ID: 17308345
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Maize ribosome-inactivating protein uses Lys158-lys161 to interact with ribosomal protein P2 and the strength of interaction is correlated to the biological activities.
    Wong YT; Ng YM; Mak AN; Sze KH; Wong KB; Shaw PC
    PLoS One; 2012; 7(12):e49608. PubMed ID: 23251345
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The C-terminal fragment of the ribosomal P protein complexed to trichosanthin reveals the interaction between the ribosome-inactivating protein and the ribosome.
    Too PH; Ma MK; Mak AN; Wong YT; Tung CK; Zhu G; Au SW; Wong KB; Shaw PC
    Nucleic Acids Res; 2009 Feb; 37(2):602-10. PubMed ID: 19073700
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
    Rudolph MJ; Dutta A; Tsymbal AM; McLaughlin JE; Chen Y; Davis SA; Theodorous SA; Pierce M; Algava B; Zhang X; Szekely Z; Roberge JY; Li XP; Tumer NE
    Bioorg Med Chem; 2024 Feb; 100():117614. PubMed ID: 38340640
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes.
    Li XP; Harijan RK; Kahn JN; Schramm VL; Tumer NE
    ACS Infect Dis; 2020 Jul; 6(7):1894-1905. PubMed ID: 32428396
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The catalytic subunit of shiga-like toxin 1 interacts with ribosomal stalk proteins and is inhibited by their conserved C-terminal domain.
    McCluskey AJ; Poon GM; Bolewska-Pedyczak E; Srikumar T; Jeram SM; Raught B; Gariépy J
    J Mol Biol; 2008 Apr; 378(2):375-86. PubMed ID: 18358491
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Solution structure of human P1•P2 heterodimer provides insights into the role of eukaryotic stalk in recruiting the ribosome-inactivating protein trichosanthin to the ribosome.
    Lee KM; Yusa K; Chu LO; Yu CW; Oono M; Miyoshi T; Ito K; Shaw PC; Wong KB; Uchiumi T
    Nucleic Acids Res; 2013 Oct; 41(18):8776-87. PubMed ID: 23892290
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2.
    Rudolph MJ; Tsymbal AM; Dutta A; Davis SA; Algava B; Roberge JY; Tumer NE; Li XP
    ACS Infect Dis; 2024 Jun; ():. PubMed ID: 38873918
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.