107 related articles for article (PubMed ID: 32890687)
1. Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite.
Zhang Y; Boy KM; Wu YJ; Ramirez A; Toyn JH; Ahlijanian MK; Albright CF; Zhuo X; Johnson BM; Denton RR; Olson RE; Thompson LA; Macor JE
Bioorg Med Chem Lett; 2020 Nov; 30(22):127530. PubMed ID: 32890687
[TBL] [Abstract][Full Text] [Related]
2. Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
Toyn JH; Boy KM; Raybon J; Meredith JE; Robertson AS; Guss V; Hoque N; Sweeney F; Zhuo X; Clarke W; Snow K; Denton RR; Zuev D; Thompson LA; Morrison J; Grace J; Berisha F; Furlong M; Wang JS; Lentz KA; Padmanabha R; Cook L; Wei C; Drexler DM; Macor JE; Albright CF; Gasior M; Olson RE; Hong Q; Soares HD; AbuTarif M; Ahlijanian MK
J Pharmacol Exp Ther; 2016 Jul; 358(1):125-37. PubMed ID: 27189974
[TBL] [Abstract][Full Text] [Related]
3. The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers.
Soares HD; Gasior M; Toyn JH; Wang JS; Hong Q; Berisha F; Furlong MT; Raybon J; Lentz KA; Sweeney F; Zheng N; Akinsanya B; Berman RM; Thompson LA; Olson RE; Morrison J; Drexler DM; Macor JE; Albright CF; Ahlijanian MK; AbuTarif M
J Pharmacol Exp Ther; 2016 Jul; 358(1):138-50. PubMed ID: 27189973
[TBL] [Abstract][Full Text] [Related]
4. Enantioselective Synthesis of a γ-Secretase Modulator via Vinylogous Dynamic Kinetic Resolution.
Strotman NA; Ramirez A; Simmons EM; Soltani O; Parsons AT; Fan Y; Sawyer JR; Rosner T; Janey JM; Tran K; Li J; La Cruz TE; Pathirana C; Ng AT; Deerberg J
J Org Chem; 2018 Sep; 83(18):11133-11144. PubMed ID: 30102035
[TBL] [Abstract][Full Text] [Related]
5. Design and optimization of tricyclic gamma-secretase modulators.
Shi J; Zuev D; Xu L; Lentz KA; Grace JE; Toyn JH; Olson RE; Macor JE; Thompson LA
Bioorg Med Chem Lett; 2016 Mar; 26(5):1498-502. PubMed ID: 26848108
[TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aβ₄₂ production.
Takai T; Koike T; Honda E; Kajita Y; Nakamura M; Morimoto S; Hoashi Y; Kamata M; Watanabe T; Igari T; Terauchi J
Bioorg Med Chem; 2015 May; 23(9):1923-34. PubMed ID: 25842363
[TBL] [Abstract][Full Text] [Related]
7. In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor.
Zhang D; Hanson R; Roongta V; Dischino DD; Gao Q; Sloan CP; Polson C; Keavy D; Zheng M; Mitroka J; Yeola S
Curr Drug Metab; 2006 Dec; 7(8):883-96. PubMed ID: 17168689
[TBL] [Abstract][Full Text] [Related]
8. Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators.
Wu YJ; Zhang Y; Toyn JH; Macor JE; Thompson LA
Bioorg Med Chem Lett; 2016 Mar; 26(6):1554-1557. PubMed ID: 26898338
[TBL] [Abstract][Full Text] [Related]
9. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice.
Sekioka R; Honda S; Akashiba H; Yarimizu J; Mitani Y; Yamasaki S
Bioorg Med Chem; 2020 Jun; 28(11):115455. PubMed ID: 32307259
[TBL] [Abstract][Full Text] [Related]
10. Anilinotriazoles as potent gamma secretase modulators.
Velter AI; Bischoff FP; Berthelot D; De Cleyn M; Oehlrich D; Jaroskova L; Macdonald G; Minne G; Pieters S; Rombouts F; Van Brandt S; Van Roosbroeck Y; Surkyn M; Trabanco AA; Tresadern G; Wu T; Borghys H; Mercken M; Masungi C; Gijsen H
Bioorg Med Chem Lett; 2014 Dec; 24(24):5805-5813. PubMed ID: 25454273
[TBL] [Abstract][Full Text] [Related]
11. Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.
Rivkin A; Ahearn SP; Chichetti SM; Kim YR; Li C; Rosenau A; Kattar SD; Jung J; Shah S; Hughes BL; Crispino JL; Middleton RE; Szewczak AA; Munoz B; Shearman MS
Bioorg Med Chem Lett; 2010 Feb; 20(3):1269-71. PubMed ID: 20022243
[TBL] [Abstract][Full Text] [Related]
12. Design and synthesis of bicyclic heterocycles as potent γ-secretase modulators.
Oehlrich D; Rombouts FJ; Berthelot D; Bischoff FP; De Cleyn MA; Jaroskova L; Macdonald G; Mercken M; Surkyn M; Trabanco AA; Tresadern G; Van Brandt S; Velter AI; Wu T; Gijsen HJ
Bioorg Med Chem Lett; 2013 Sep; 23(17):4794-800. PubMed ID: 23890837
[TBL] [Abstract][Full Text] [Related]
13. Discovery of N-ethylpyridine-2-carboxamide derivatives as a novel scaffold for orally active γ-secretase modulators.
Sekioka R; Honda S; Honjo E; Suzuki T; Akashiba H; Mitani Y; Yamasaki S
Bioorg Med Chem; 2020 Jan; 28(1):115132. PubMed ID: 31767402
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.
Rynearson KD; Buckle RN; Barnes KD; Herr RJ; Mayhew NJ; Paquette WD; Sakwa SA; Nguyen PD; Johnson G; Tanzi RE; Wagner SL
Bioorg Med Chem Lett; 2016 Aug; 26(16):3928-37. PubMed ID: 27426299
[TBL] [Abstract][Full Text] [Related]
15. Design and synthesis of an aminopiperidine series of γ-secretase modulators.
Kobayashi T; Iwama S; Fusano A; Kato Y; Ikeda A; Teranishi Y; Nishihara A; Tobe M
Bioorg Med Chem Lett; 2014 Jan; 24(1):378-81. PubMed ID: 24269163
[TBL] [Abstract][Full Text] [Related]
16. BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
Scannevin RH; Chollate S; Brennan MS; Snodgrass-Belt PA; Peng H; Xu L; Jung MY; Bussiere T; Arastu MF; Talreja T; Xin Z; Dunstan RW; Fahrer D; Rohde E; Dunah AW; Wang J; Kumaravel G; Taveras AG; Moore Arnold H; Rhodes KJ
Neuropharmacology; 2016 Apr; 103():57-68. PubMed ID: 26690893
[TBL] [Abstract][Full Text] [Related]
17. Discovery of novel scaffolds for γ-secretase modulators without an arylimidazole moiety.
Sekioka R; Honjo E; Honda S; Fuji H; Akashiba H; Mitani Y; Yamasaki S
Bioorg Med Chem; 2018 Jan; 26(2):435-442. PubMed ID: 29249626
[TBL] [Abstract][Full Text] [Related]
18. Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells.
Rennhack A; Jumpertz T; Ness J; Baches S; Pietrzik CU; Weggen S; Bulic B
Bioorg Med Chem; 2012 Nov; 20(21):6523-32. PubMed ID: 23000293
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of a novel series of bicyclic heterocycles as potent γ-secretase modulators.
Bischoff F; Berthelot D; De Cleyn M; Macdonald G; Minne G; Oehlrich D; Pieters S; Surkyn M; Trabanco AA; Tresadern G; Van Brandt S; Velter I; Zaja M; Borghys H; Masungi C; Mercken M; Gijsen HJ
J Med Chem; 2012 Nov; 55(21):9089-106. PubMed ID: 22650177
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.
Hieke M; Ness J; Steri R; Dittrich M; Greiner C; Werz O; Baumann K; Schubert-Zsilavecz M; Weggen S; Zettl H
J Med Chem; 2010 Jun; 53(12):4691-700. PubMed ID: 20503989
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
