247 related articles for article (PubMed ID: 32937901)
1. Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to.
Carofiglio F; Trisciuzzi D; Gambacorta N; Leonetti F; Stefanachi A; Nicolotti O
Molecules; 2020 Sep; 25(18):. PubMed ID: 32937901
[TBL] [Abstract][Full Text] [Related]
2. Drug repurposing for chronic myeloid leukemia: in silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors.
Singh VK; Chang HH; Kuo CC; Shiao HY; Hsieh HP; Coumar MS
J Biomol Struct Dyn; 2017 Jun; 35(8):1833-1848. PubMed ID: 27353341
[TBL] [Abstract][Full Text] [Related]
3. Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I.
Mian AA; Metodieva A; Badura S; Khateb M; Ruimi N; Najajreh Y; Ottmann OG; Mahajna J; Ruthardt M
BMC Cancer; 2012 Sep; 12():411. PubMed ID: 22985168
[TBL] [Abstract][Full Text] [Related]
4. Discovery of novel Bcr-Abl inhibitors targeting myristoyl pocket and ATP site.
Dong J; Lu W; Pan X; Su P; Shi Y; Wang J; Zhang J
Bioorg Med Chem; 2014 Dec; 22(24):6876-84. PubMed ID: 25464886
[TBL] [Abstract][Full Text] [Related]
5. In-silico identification of inhibitors against mutated BCR-ABL protein of chronic myeloid leukemia: a virtual screening and molecular dynamics simulation study.
Kumar H; Raj U; Gupta S; Varadwaj PK
J Biomol Struct Dyn; 2016 Oct; 34(10):2171-83. PubMed ID: 26479578
[TBL] [Abstract][Full Text] [Related]
6. Allosteric inhibitors of Bcr-Abl: towards novel myristate-pocket binders.
Radi M; Schenone S; Botta M
Curr Pharm Biotechnol; 2013; 14(5):477-87. PubMed ID: 22429131
[TBL] [Abstract][Full Text] [Related]
7. Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABL.
Mian AA; Oancea C; Zhao Z; Ottmann OG; Ruthardt M
Leukemia; 2009 Dec; 23(12):2242-7. PubMed ID: 19798092
[TBL] [Abstract][Full Text] [Related]
8. Discovery of allosteric BCR-ABL inhibitors from phenotypic screen to clinical candidate.
Gray NS; Fabbro D
Methods Enzymol; 2014; 548():173-88. PubMed ID: 25399646
[TBL] [Abstract][Full Text] [Related]
9. Expanding the diversity of allosteric bcr-abl inhibitors.
Deng X; Okram B; Ding Q; Zhang J; Choi Y; Adrián FJ; Wojciechowski A; Zhang G; Che J; Bursulaya B; Cowan-Jacob SW; Rummel G; Sim T; Gray NS
J Med Chem; 2010 Oct; 53(19):6934-46. PubMed ID: 20828158
[TBL] [Abstract][Full Text] [Related]
10. Dual Drug Targeting of Mutant Bcr-Abl Induces Inactive Conformation: New Strategy for the Treatment of Chronic Myeloid Leukemia and Overcoming Monotherapy Resistance.
El Rashedy AA; Olotu FA; Soliman MES
Chem Biodivers; 2018 Mar; 15(3):e1700533. PubMed ID: 29325229
[TBL] [Abstract][Full Text] [Related]
11. Ensemble-based virtual screening: identification of a potential allosteric inhibitor of Bcr-Abl.
Singh VK; Coumar MS
J Mol Model; 2017 Jul; 23(7):218. PubMed ID: 28669127
[TBL] [Abstract][Full Text] [Related]
12. Allosteric inhibitors of Bcr-abl-dependent cell proliferation.
Adrián FJ; Ding Q; Sim T; Velentza A; Sloan C; Liu Y; Zhang G; Hur W; Ding S; Manley P; Mestan J; Fabbro D; Gray NS
Nat Chem Biol; 2006 Feb; 2(2):95-102. PubMed ID: 16415863
[TBL] [Abstract][Full Text] [Related]
13. Predictive models for designing potent tyrosine kinase inhibitors in chronic myeloid leukemia for understanding its molecular mechanism of resistance by molecular docking and dynamics simulations.
Melge AR; Kumar LG; K P; Nair SV; K M; C GM
J Biomol Struct Dyn; 2019 Nov; 37(18):4747-4766. PubMed ID: 30580670
[TBL] [Abstract][Full Text] [Related]
14. Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1
Mian AA; Haberbosch I; Khamaisie H; Agbarya A; Pietsch L; Eshel E; Najib D; Chiriches C; Ottmann OG; Hantschel O; Biondi RM; Ruthardt M; Mahajna J
Ann Hematol; 2021 Aug; 100(8):2023-2029. PubMed ID: 34110462
[TBL] [Abstract][Full Text] [Related]
15. Emodin Inhibits Resistance to Imatinib by Downregulation of Bcr-Abl and STAT5 and Allosteric Inhibition in Chronic Myeloid Leukemia Cells.
Wang XY; Sun GB; Wang YJ; Yan F
Biol Pharm Bull; 2020; 43(10):1526-1533. PubMed ID: 32999163
[TBL] [Abstract][Full Text] [Related]
16. p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia.
Mian AA; Metodieva A; Najajreh Y; Ottmann OG; Mahajna J; Ruthardt M
Haematologica; 2012 Feb; 97(2):251-7. PubMed ID: 22058195
[TBL] [Abstract][Full Text] [Related]
17. Development of Alkyne-Containing Pyrazolopyrimidines To Overcome Drug Resistance of Bcr-Abl Kinase.
Liu X; Kung A; Malinoski B; Prakash GK; Zhang C
J Med Chem; 2015 Dec; 58(23):9228-37. PubMed ID: 26562217
[TBL] [Abstract][Full Text] [Related]
18. Enhanced ABL-inhibitor-induced MAPK-activation in T315I-BCR-ABL-expressing cells: a potential mechanism of altered leukemogenicity.
Härtel N; Klag T; Hanfstein B; Mueller MC; Schenk T; Erben P; Hochhaus A; La Rosée P
J Cancer Res Clin Oncol; 2012 Feb; 138(2):203-12. PubMed ID: 22089930
[TBL] [Abstract][Full Text] [Related]
19. Imatinib can act as an Allosteric Activator of Abl Kinase.
Xie T; Saleh T; Rossi P; Miller D; Kalodimos CG
J Mol Biol; 2022 Jan; 434(2):167349. PubMed ID: 34774565
[TBL] [Abstract][Full Text] [Related]
20. New Bcr-Abl inhibitors in chronic myeloid leukemia: keeping resistance in check.
O'Hare T; Eide CA; Deininger MW
Expert Opin Investig Drugs; 2008 Jun; 17(6):865-78. PubMed ID: 18491988
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]