These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 32938719)

  • 1. GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Potet F; Egecioglu DE; Burridge PW; George AL
    Mol Pharmacol; 2020 Nov; 98(5):540-547. PubMed ID: 32938719
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Use-Dependent Block of Human Cardiac Sodium Channels by GS967.
    Potet F; Vanoye CG; George AL
    Mol Pharmacol; 2016 Jul; 90(1):52-60. PubMed ID: 27136942
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Eleclazine exhibits enhanced selectivity for long QT syndrome type 3-associated late Na
    El-Bizri N; Xie C; Liu L; Limberis J; Krause M; Hirakawa R; Nguyen S; Tabuena DR; Belardinelli L; Kahlig KM
    Heart Rhythm; 2018 Feb; 15(2):277-286. PubMed ID: 29017927
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    El-Battrawy I; Lang S; Zhao Z; Akin I; Yücel G; Meister S; Patocskai B; Behnes M; Rudic B; Tülümen E; Liebe V; Tiburcy M; Dworacek J; Zimmermann WH; Utikal J; Wieland T; Borggrefe M; Zhou XB
    PLoS One; 2016; 11(11):e0166143. PubMed ID: 27829006
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.
    Yang PC; Song Y; Giles WR; Horvath B; Chen-Izu Y; Belardinelli L; Rajamani S; Clancy CE
    J Physiol; 2015 Mar; 593(6):1429-42. PubMed ID: 25545172
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.
    Portero V; Casini S; Hoekstra M; Verkerk AO; Mengarelli I; Belardinelli L; Rajamani S; Wilde AAM; Bezzina CR; Veldkamp MW; Remme CA
    Cardiovasc Res; 2017 Jun; 113(7):829-838. PubMed ID: 28430892
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action.
    Fredj S; Sampson KJ; Liu H; Kass RS
    Br J Pharmacol; 2006 May; 148(1):16-24. PubMed ID: 16520744
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine.
    Burashnikov A; Di Diego JM; Zygmunt AC; Belardinelli L; Antzelevitch C
    Circulation; 2007 Sep; 116(13):1449-57. PubMed ID: 17785620
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human-induced pluripotent stem cell-derived cardiomyocytes from cardiac progenitor cells: effects of selective ion channel blockade.
    Altomare C; Pianezzi E; Cervio E; Bolis S; Biemmi V; Benzoni P; Camici GG; Moccetti T; Barile L; Vassalli G
    Europace; 2016 Dec; 18(suppl 4):iv67-iv76. PubMed ID: 28011833
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The novel late Na
    Rajamani S; Liu G; El-Bizri N; Guo D; Li C; Chen XL; Kahlig KM; Mollova N; Elzein E; Zablocki J; Belardinelli L
    Br J Pharmacol; 2016 Nov; 173(21):3088-3098. PubMed ID: 27449698
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanisms of atrial fibrillation termination by rapidly unbinding Na+ channel blockers: insights from mathematical models and experimental correlates.
    Comtois P; Sakabe M; Vigmond EJ; Munoz M; Texier A; Shiroshita-Takeshita A; Nattel S
    Am J Physiol Heart Circ Physiol; 2008 Oct; 295(4):H1489-504. PubMed ID: 18676686
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Selective inhibition of physiological late Na
    El-Bizri N; Li CH; Liu GX; Rajamani S; Belardinelli L
    Am J Physiol Heart Circ Physiol; 2018 Feb; 314(2):H236-H245. PubMed ID: 28971840
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells.
    Strege P; Beyder A; Bernard C; Crespo-Diaz R; Behfar A; Terzic A; Ackerman M; Farrugia G
    Channels (Austin); 2012; 6(6):457-62. PubMed ID: 23018927
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of late Na+ current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats.
    Chi L; Belardinelli L; Zeng A; Hirakawa R; Rajamani S; Ling H; Dhalla AK
    Am J Physiol Heart Circ Physiol; 2016 May; 310(10):H1313-20. PubMed ID: 26993228
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block.
    Zhu Y; Kyle JW; Lee PJ
    Am J Physiol Heart Circ Physiol; 2006 Jul; 291(1):H29-37. PubMed ID: 16501012
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of voltage-gated Na
    Caves RE; Carpenter A; Choisy SC; Clennell B; Cheng H; McNiff C; Mann B; Milnes JT; Hancox JC; James AF
    Heart Rhythm O2; 2020 Aug; 1(3):206-214. PubMed ID: 32864638
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers.
    Izumi-Nakaseko H; Hagiwara-Nagasawa M; Naito AT; Goto A; Chiba K; Sekino Y; Kanda Y; Sugiyama A
    J Pharmacol Sci; 2018 Aug; 137(4):372-378. PubMed ID: 30126708
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.
    Sheets MF; Hanck DA
    J Physiol; 2007 Jul; 582(Pt 1):317-34. PubMed ID: 17510181
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine.
    Koltun DO; Parkhill EQ; Elzein E; Kobayashi T; Notte GT; Kalla R; Jiang RH; Li X; Perry TD; Avila B; Wang WQ; Smith-Maxwell C; Dhalla AK; Rajamani S; Stafford B; Tang J; Mollova N; Belardinelli L; Zablocki JA
    Bioorg Med Chem Lett; 2016 Jul; 26(13):3202-3206. PubMed ID: 27080178
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation.
    Burashnikov A; Belardinelli L; Antzelevitch C
    Heart Rhythm; 2015 Apr; 12(4):836-44. PubMed ID: 25546810
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.