124 related articles for article (PubMed ID: 32941796)
1. Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila.
Chatterjee M; Steffan JS; Lukacsovich T; Marsh JL; Agrawal N
Exp Neurol; 2021 Apr; 338():113463. PubMed ID: 32941796
[TBL] [Abstract][Full Text] [Related]
2. Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT.
Chongtham A; Bornemann DJ; Barbaro BA; Lukacsovich T; Agrawal N; Syed A; Worthge S; Purcell J; Burke J; Chin TM; Marsh JL
Hum Mol Genet; 2020 Mar; 29(4):674-688. PubMed ID: 31943010
[TBL] [Abstract][Full Text] [Related]
3. Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity.
Arbez N; Ratovitski T; Roby E; Chighladze E; Stewart JC; Ren M; Wang X; Lavery DJ; Ross CA
J Biol Chem; 2017 Nov; 292(47):19238-19249. PubMed ID: 28972180
[TBL] [Abstract][Full Text] [Related]
4. Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Kratter IH; Zahed H; Lau A; Tsvetkov AS; Daub AC; Weiberth KF; Gu X; Saudou F; Humbert S; Yang XW; Osmand A; Steffan JS; Masliah E; Finkbeiner S
J Clin Invest; 2016 Sep; 126(9):3585-97. PubMed ID: 27525439
[TBL] [Abstract][Full Text] [Related]
5. Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13.
Cariulo C; Verani M; Martufi P; Ingenito R; Finotto M; Deguire SM; Lavery DJ; Toledo-Sherman L; Lee R; Doherty EM; Vogt TF; Dominguez C; Lashuel HA; Petricca L; Caricasole A
Biochem Biophys Res Commun; 2020 Jan; 521(3):549-554. PubMed ID: 31677786
[TBL] [Abstract][Full Text] [Related]
6. Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Gu X; Greiner ER; Mishra R; Kodali R; Osmand A; Finkbeiner S; Steffan JS; Thompson LM; Wetzel R; Yang XW
Neuron; 2009 Dec; 64(6):828-40. PubMed ID: 20064390
[TBL] [Abstract][Full Text] [Related]
7. Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity.
Lemarié FL; Caron NS; Sanders SS; Schmidt ME; Nguyen YTN; Ko S; Xu X; Pouladi MA; Martin DDO; Hayden MR
Neurobiol Dis; 2021 Oct; 158():105479. PubMed ID: 34390831
[TBL] [Abstract][Full Text] [Related]
8. CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington's Disease.
Kolli N; Lu M; Maiti P; Rossignol J; Dunbar GL
Int J Mol Sci; 2017 Apr; 18(4):. PubMed ID: 28368337
[TBL] [Abstract][Full Text] [Related]
9. Pan-neuronal expression of human mutant huntingtin protein in Drosophila impairs immune response of hemocytes.
Dhankhar J; Agrawal N; Shrivastava A
J Neuroimmunol; 2022 Feb; 363():577801. PubMed ID: 34973473
[TBL] [Abstract][Full Text] [Related]
10. Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs.
Tong H; Yang T; Liu L; Li C; Sun Y; Jia Q; Qin Y; Chen L; Zhao X; Zhou G; Yan S; Li XJ; Li S
Neurobiol Dis; 2023 Oct; 187():106291. PubMed ID: 37716514
[TBL] [Abstract][Full Text] [Related]
11. N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.
DeGuire SM; Ruggeri FS; Fares MB; Chiki A; Cendrowska U; Dietler G; Lashuel HA
J Biol Chem; 2018 Nov; 293(48):18540-18558. PubMed ID: 30185623
[TBL] [Abstract][Full Text] [Related]
12. The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.
Veldman MB; Rios-Galdamez Y; Lu XH; Gu X; Qin W; Li S; Yang XW; Lin S
Mol Neurodegener; 2015 Dec; 10():67. PubMed ID: 26645399
[TBL] [Abstract][Full Text] [Related]
13. TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models.
Hegde RN; Chiki A; Petricca L; Martufi P; Arbez N; Mouchiroud L; Auwerx J; Landles C; Bates GP; Singh-Bains MK; Dragunow M; Curtis MA; Faull RL; Ross CA; Caricasole A; Lashuel HA
EMBO J; 2020 Sep; 39(17):e104671. PubMed ID: 32757223
[TBL] [Abstract][Full Text] [Related]
14. Design and characterization of mutant and wildtype huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems.
Harding RJ; Loppnau P; Ackloo S; Lemak A; Hutchinson A; Hunt B; Holehouse AS; Ho JC; Fan L; Toledo-Sherman L; Seitova A; Arrowsmith CH
J Biol Chem; 2019 Apr; 294(17):6986-7001. PubMed ID: 30842263
[TBL] [Abstract][Full Text] [Related]
15. Rab8 Promotes Mutant HTT Aggregation, Reduces Neurodegeneration, and Ameliorates Behavioural Alterations in a Drosophila Model of Huntington's Disease.
Delfino L; Mason RP; Kyriacou CP; Giorgini F; Rosato E
J Huntingtons Dis; 2020; 9(3):253-263. PubMed ID: 33044189
[TBL] [Abstract][Full Text] [Related]
16. Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
Sahoo B; Arduini I; Drombosky KW; Kodali R; Sanders LH; Greenamyre JT; Wetzel R
PLoS One; 2016; 11(6):e0155747. PubMed ID: 27271685
[TBL] [Abstract][Full Text] [Related]
17. Pathogenic Huntington Alters BMP Signaling and Synaptic Growth through Local Disruptions of Endosomal Compartments.
Akbergenova Y; Littleton JT
J Neurosci; 2017 Mar; 37(12):3425-3439. PubMed ID: 28235896
[TBL] [Abstract][Full Text] [Related]
18. Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties.
Mishra R; Hoop CL; Kodali R; Sahoo B; van der Wel PC; Wetzel R
J Mol Biol; 2012 Nov; 424(1-2):1-14. PubMed ID: 22999956
[TBL] [Abstract][Full Text] [Related]
19. Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model.
Wood TE; Barry J; Yang Z; Cepeda C; Levine MS; Gray M
Hum Mol Genet; 2019 Feb; 28(3):487-500. PubMed ID: 30312396
[TBL] [Abstract][Full Text] [Related]
20. Peripheral Expression of Mutant Huntingtin is a Critical Determinant of Weight Loss and Metabolic Disturbances in Huntington's Disease.
Lakra P; Aditi K; Agrawal N
Sci Rep; 2019 Jul; 9(1):10127. PubMed ID: 31300691
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
