BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 32986422)

  • 1. Toxic Metamorphosis-How Changes from Lysosomal to Cytosolic pH Modify the Alpha-Synuclein Aggregation Pattern.
    Eymsh B; Drobny A; Heyn TR; Xiang W; Lucius R; Schwarz K; Keppler JK; Zunke F; Arnold P
    Biomacromolecules; 2020 Dec; 21(12):4673-4684. PubMed ID: 32986422
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain.
    Svarcbahs R; Julku UH; Myöhänen TT
    J Neurosci; 2016 Dec; 36(49):12485-12497. PubMed ID: 27927963
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.
    Hoffmann AC; Minakaki G; Menges S; Salvi R; Savitskiy S; Kazman A; Vicente Miranda H; Mielenz D; Klucken J; Winkler J; Xiang W
    Sci Rep; 2019 Jan; 9(1):544. PubMed ID: 30679445
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Alpha-Synuclein and GM1 Ganglioside Co-Localize in Neuronal Cytosol Leading to Inverse Interaction-Relevance to Parkinson's Disease.
    Kumar R; Chowdhury S; Ledeen R
    Int J Mol Sci; 2024 Mar; 25(6):. PubMed ID: 38542297
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular characterization of an aggregation-prone variant of alpha-synuclein used to model synucleinopathies.
    Masaracchia C; König A; Valiente-Gabioud AA; Peralta P; Favretto F; Strohäker T; Lázaro DF; Zweckstetter M; Fernandez CO; Outeiro TF
    Biochim Biophys Acta Proteins Proteom; 2020 Jan; 1868(1):140298. PubMed ID: 31676453
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Small-angle neutron scattering reveals the assembly of alpha-synuclein in lipid membranes.
    Anunciado D; Rai DK; Qian S; Urban V; O'Neill H
    Biochim Biophys Acta; 2015 Dec; 1854(12):1881-1889. PubMed ID: 26321599
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation.
    Gustavsson N; Savchenko E; Klementieva O; Roybon L
    Acta Neuropathol Commun; 2021 Sep; 9(1):153. PubMed ID: 34530929
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins.
    Vaneyck J; Segers-Nolten I; Broersen K; Claessens MMAE
    J Biol Chem; 2021; 296():100358. PubMed ID: 33539920
    [TBL] [Abstract][Full Text] [Related]  

  • 9. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.
    Gonçalves SA; Macedo D; Raquel H; Simões PD; Giorgini F; Ramalho JS; Barral DC; Ferreira Moita L; Outeiro TF
    PLoS Genet; 2016 Apr; 12(4):e1005995. PubMed ID: 27123591
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Membrane binding, internalization, and sorting of alpha-synuclein in the cell.
    Masaracchia C; Hnida M; Gerhardt E; Lopes da Fonseca T; Villar-Pique A; Branco T; Stahlberg MA; Dean C; Fernández CO; Milosevic I; Outeiro TF
    Acta Neuropathol Commun; 2018 Aug; 6(1):79. PubMed ID: 30107856
    [TBL] [Abstract][Full Text] [Related]  

  • 11. DJ-1, a Parkinson's disease related protein, aggregates under denaturing conditions and co-aggregates with α-synuclein through hydrophobic interaction.
    Zhu M; H Patel S; Han S
    Biochim Biophys Acta Gen Subj; 2017 Jul; 1861(7):1759-1769. PubMed ID: 28330770
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dependence of alpha-synuclein aggregate morphology on solution conditions.
    Hoyer W; Antony T; Cherny D; Heim G; Jovin TM; Subramaniam V
    J Mol Biol; 2002 Sep; 322(2):383-93. PubMed ID: 12217698
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
    Lázaro DF; Rodrigues EF; Langohr R; Shahpasandzadeh H; Ribeiro T; Guerreiro P; Gerhardt E; Kröhnert K; Klucken J; Pereira MD; Popova B; Kruse N; Mollenhauer B; Rizzoli SO; Braus GH; Danzer KM; Outeiro TF
    PLoS Genet; 2014 Nov; 10(11):e1004741. PubMed ID: 25393002
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease.
    Price DL; Koike MA; Khan A; Wrasidlo W; Rockenstein E; Masliah E; Bonhaus D
    Sci Rep; 2018 Nov; 8(1):16165. PubMed ID: 30385782
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.
    Villar-Piqué A; Lopes da Fonseca T; Sant'Anna R; Szegö ÉM; Fonseca-Ornelas L; Pinho R; Carija A; Gerhardt E; Masaracchia C; Abad Gonzalez E; Rossetti G; Carloni P; Fernández CO; Foguel D; Milosevic I; Zweckstetter M; Ventura S; Outeiro TF
    Proc Natl Acad Sci U S A; 2016 Oct; 113(42):E6506-E6515. PubMed ID: 27708160
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.
    Van Den Berge N; Ferreira N; Gram H; Mikkelsen TW; Alstrup AKO; Casadei N; Tsung-Pin P; Riess O; Nyengaard JR; Tamgüney G; Jensen PH; Borghammer P
    Acta Neuropathol; 2019 Oct; 138(4):535-550. PubMed ID: 31254094
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease.
    Gonçalves SA; Outeiro TF
    Small GTPases; 2017 Apr; 8(2):78-84. PubMed ID: 27314512
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity.
    Ysselstein D; Dehay B; Costantino IM; McCabe GP; Frosch MP; George JM; Bezard E; Rochet JC
    Acta Neuropathol Commun; 2017 Jan; 5(1):3. PubMed ID: 28069058
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Alpha synuclein dimers and oligomers are increased in overexpressing conditions in vitro and in vivo.
    Marmolino D; Foerch P; Atienzar FA; Staelens L; Michel A; Scheller D
    Mol Cell Neurosci; 2016 Mar; 71():92-101. PubMed ID: 26711807
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Direct current stimulation enhances neuronal alpha-synuclein degradation in vitro.
    Sala G; Bocci T; Borzì V; Parazzini M; Priori A; Ferrarese C
    Sci Rep; 2021 Jan; 11(1):2197. PubMed ID: 33500442
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.