These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

376 related articles for article (PubMed ID: 32999459)

  • 1. Repeat expansions confer WRN dependence in microsatellite-unstable cancers.
    van Wietmarschen N; Sridharan S; Nathan WJ; Tubbs A; Chan EM; Callen E; Wu W; Belinky F; Tripathi V; Wong N; Foster K; Noorbakhsh J; Garimella K; Cruz-Migoni A; Sommers JA; Huang Y; Borah AA; Smith JT; Kalfon J; Kesten N; Fugger K; Walker RL; Dolzhenko E; Eberle MA; Hayward BE; Usdin K; Freudenreich CH; Brosh RM; West SC; McHugh PJ; Meltzer PS; Bass AJ; Nussenzweig A
    Nature; 2020 Oct; 586(7828):292-298. PubMed ID: 32999459
    [TBL] [Abstract][Full Text] [Related]  

  • 2. WRN Is a Promising Synthetic Lethal Target for Cancers with Microsatellite Instability (MSI).
    Chan EM; Foster KJ; Bass AJ
    Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
    [TBL] [Abstract][Full Text] [Related]  

  • 3. WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
    Chan EM; Shibue T; McFarland JM; Gaeta B; Ghandi M; Dumont N; Gonzalez A; McPartlan JS; Li T; Zhang Y; Bin Liu J; Lazaro JB; Gu P; Piett CG; Apffel A; Ali SO; Deasy R; Keskula P; Ng RWS; Roberts EA; Reznichenko E; Leung L; Alimova M; Schenone M; Islam M; Maruvka YE; Liu Y; Roper J; Raghavan S; Giannakis M; Tseng YY; Nagel ZD; D'Andrea A; Root DE; Boehm JS; Getz G; Chang S; Golub TR; Tsherniak A; Vazquez F; Bass AJ
    Nature; 2019 Apr; 568(7753):551-556. PubMed ID: 30971823
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells.
    Picco G; Rao Y; Al Saedi A; Lee Y; Vieira SF; Bhosle S; May K; Herranz-Ors C; Walker SJ; Shenje R; Dincer C; Gibson F; Banerjee R; Hewitson Z; Werner T; Cottom JE; Peng Y; Deng N; Zhang Y; Nartey EN; Nickels L; Landis P; Conticelli D; McCarten K; Bush J; Sharma M; Lightfoot H; House D; Milford E; Grant EK; Glogowski MP; Wagner CD; Bantscheff M; Rutkowska-Klute A; ; Zappacosta F; Pettinger J; Barthorpe S; Eberl HC; Jones BT; Schneck JL; Murphy DJ; Voest EE; Taygerly JP; DeMartino MP; Coelho MA; Houseley J; Sharma G; Schwartz B; Garnett MJ
    Cancer Discov; 2024 Aug; 14(8):1457-1475. PubMed ID: 38587317
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
    Zong D; Koussa NC; Cornwell JA; Pankajam AV; Kruhlak MJ; Wong N; Chari R; Cappell SD; Nussenzweig A
    Genes Dev; 2023 Oct; 37(19-20):913-928. PubMed ID: 37932011
    [TBL] [Abstract][Full Text] [Related]  

  • 6. WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures.
    Mengoli V; Ceppi I; Sanchez A; Cannavo E; Halder S; Scaglione S; Gaillard PH; McHugh PJ; Riesen N; Pettazzoni P; Cejka P
    EMBO J; 2023 Feb; 42(3):e111998. PubMed ID: 36541070
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation.
    Murfuni I; Nicolai S; Baldari S; Crescenzi M; Bignami M; Franchitto A; Pichierri P
    Oncogene; 2013 Jan; 32(5):610-20. PubMed ID: 22410776
    [TBL] [Abstract][Full Text] [Related]  

  • 8. PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability.
    Tejwani V; Carroll T; Macartney T; Bandau S; Alabert C; Saredi G; Toth R; Rouse J
    Sci Rep; 2024 Sep; 14(1):20824. PubMed ID: 39242638
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.
    Franchitto A; Pirzio LM; Prosperi E; Sapora O; Bignami M; Pichierri P
    J Cell Biol; 2008 Oct; 183(2):241-52. PubMed ID: 18852298
    [TBL] [Abstract][Full Text] [Related]  

  • 10. WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells.
    Datta A; Biswas K; Sommers JA; Thompson H; Awate S; Nicolae CM; Thakar T; Moldovan GL; Shoemaker RH; Sharan SK; Brosh RM
    Nat Commun; 2021 Nov; 12(1):6561. PubMed ID: 34772932
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
    Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
    Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.
    Murfuni I; De Santis A; Federico M; Bignami M; Pichierri P; Franchitto A
    Carcinogenesis; 2012 Sep; 33(9):1655-63. PubMed ID: 22689923
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery.
    Ammazzalorso F; Pirzio LM; Bignami M; Franchitto A; Pichierri P
    EMBO J; 2010 Sep; 29(18):3156-69. PubMed ID: 20802463
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
    Aggarwal M; Banerjee T; Sommers JA; Iannascoli C; Pichierri P; Shoemaker RH; Brosh RM
    Cancer Res; 2013 Sep; 73(17):5497-507. PubMed ID: 23867477
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of thiophen-2-ylmethylene bis-dimedone derivatives as novel WRN inhibitors for treating cancers with microsatellite instability.
    Yang H; Kang M; Jang S; Baek SY; Kim J; Kim GU; Kim D; Ha J; Kim JS; Jung C; Kim NJ; Cho SY; Shin WH; Lee J; Ko J; Lee A; Keum G; Lee S; Kang T
    Bioorg Med Chem; 2024 Feb; 100():117588. PubMed ID: 38295487
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Werner Syndrome Protein and DNA Replication.
    Mukherjee S; Sinha D; Bhattacharya S; Srinivasan K; Abdisalaam S; Asaithamby A
    Int J Mol Sci; 2018 Nov; 19(11):. PubMed ID: 30400178
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
    Lee SJ; Gartner A; Hyun M; Ahn B; Koo HS
    PLoS Genet; 2010 Jan; 6(1):e1000801. PubMed ID: 20062519
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.
    Kategaya L; Perumal SK; Hager JH; Belmont LD
    iScience; 2019 Mar; 13():488-497. PubMed ID: 30898619
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase.
    Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
    Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
    Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
    Elife; 2019 Mar; 8():. PubMed ID: 30910006
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.