BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

573 related articles for article (PubMed ID: 33028409)

  • 1. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
    Huang M; Modeste E; Dammer E; Merino P; Taylor G; Duong DM; Deng Q; Holler CJ; Gearing M; Dickson D; Seyfried NT; Kukar T
    Acta Neuropathol Commun; 2020 Oct; 8(1):163. PubMed ID: 33028409
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by
    Holler CJ; Taylor G; Deng Q; Kukar T
    eNeuro; 2017; 4(4):. PubMed ID: 28828399
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
    Arrant AE; Onyilo VC; Unger DE; Roberson ED
    J Neurosci; 2018 Feb; 38(9):2341-2358. PubMed ID: 29378861
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice.
    Götzl JK; Colombo AV; Fellerer K; Reifschneider A; Werner G; Tahirovic S; Haass C; Capell A
    Mol Neurodegener; 2018 Sep; 13(1):48. PubMed ID: 30180904
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD.
    Wu Y; Shao W; Todd TW; Tong J; Yue M; Koga S; Castanedes-Casey M; Librero AL; Lee CW; Mackenzie IR; Dickson DW; Zhang YJ; Petrucelli L; Prudencio M
    Cell Rep; 2021 Aug; 36(8):109581. PubMed ID: 34433069
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
    Holler CJ; Taylor G; McEachin ZT; Deng Q; Watkins WJ; Hudson K; Easley CA; Hu WT; Hales CM; Rossoll W; Bassell GJ; Kukar T
    Mol Neurodegener; 2016 Jun; 11(1):46. PubMed ID: 27341800
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
    Arrant AE; Roth JR; Boyle NR; Kashyap SN; Hoffmann MQ; Murchison CF; Ramos EM; Nana AL; Spina S; Grinberg LT; Miller BL; Seeley WW; Roberson ED
    Acta Neuropathol Commun; 2019 Dec; 7(1):218. PubMed ID: 31870439
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
    Boland S; Swarup S; Ambaw YA; Malia PC; Richards RC; Fischer AW; Singh S; Aggarwal G; Spina S; Nana AL; Grinberg LT; Seeley WW; Surma MA; Klose C; Paulo JA; Nguyen AD; Harper JW; Walther TC; Farese RV
    Nat Commun; 2022 Oct; 13(1):5924. PubMed ID: 36207292
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.
    Hasan S; Fernandopulle MS; Humble SW; Frankenfield AM; Li H; Prestil R; Johnson KR; Ryan BJ; Wade-Martins R; Ward ME; Hao L
    Mol Neurodegener; 2023 Nov; 18(1):87. PubMed ID: 37974165
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.
    Root J; Merino P; Nuckols A; Johnson M; Kukar T
    Neurobiol Dis; 2021 Jul; 154():105360. PubMed ID: 33812000
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
    Davis SE; Cook AK; Hall JA; Voskobiynyk Y; Carullo NV; Boyle NR; Hakim AR; Anderson KM; Hobdy KP; Pugh DA; Murchison CF; McMeekin LJ; Simmons M; Margolies KA; Cowell RM; Nana AL; Spina S; Grinberg LT; Miller BL; Seeley WW; Arrant AE
    Acta Neuropathol Commun; 2023 Apr; 11(1):70. PubMed ID: 37118844
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations.
    Marian OC; Teo JD; Lee JY; Song H; Kwok JB; Landin-Romero R; Halliday G; Don AS
    Acta Neuropathol Commun; 2023 Mar; 11(1):52. PubMed ID: 36967384
    [TBL] [Abstract][Full Text] [Related]  

  • 13. New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.
    Amin S; Carling G; Gan L
    Curr Opin Neurobiol; 2022 Feb; 72():131-139. PubMed ID: 34826653
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
    Logan T; Simon MJ; Rana A; Cherf GM; Srivastava A; Davis SS; Low RLY; Chiu CL; Fang M; Huang F; Bhalla A; Llapashtica C; Prorok R; Pizzo ME; Calvert MEK; Sun EW; Hsiao-Nakamoto J; Rajendra Y; Lexa KW; Srivastava DB; van Lengerich B; Wang J; Robles-Colmenares Y; Kim DJ; Duque J; Lenser M; Earr TK; Nguyen H; Chau R; Tsogtbaatar B; Ravi R; Skuja LL; Solanoy H; Rosen HJ; Boeve BF; Boxer AL; Heuer HW; Dennis MS; Kariolis MS; Monroe KM; Przybyla L; Sanchez PE; Meisner R; Diaz D; Henne KR; Watts RJ; Henry AG; Gunasekaran K; Astarita G; Suh JH; Lewcock JW; DeVos SL; Di Paolo G
    Cell; 2021 Sep; 184(18):4651-4668.e25. PubMed ID: 34450028
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
    Ward ME; Chen R; Huang HY; Ludwig C; Telpoukhovskaia M; Taubes A; Boudin H; Minami SS; Reichert M; Albrecht P; Gelfand JM; Cruz-Herranz A; Cordano C; Alavi MV; Leslie S; Seeley WW; Miller BL; Bigio E; Mesulam MM; Bogyo MS; Mackenzie IR; Staropoli JF; Cotman SL; Huang EJ; Gan L; Green AJ
    Sci Transl Med; 2017 Apr; 9(385):. PubMed ID: 28404863
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.
    Valdez C; Wong YC; Schwake M; Bu G; Wszolek ZK; Krainc D
    Hum Mol Genet; 2017 Dec; 26(24):4861-4872. PubMed ID: 29036611
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
    Zhang T; Feng T; Wu K; Guo J; Nana AL; Yang G; Seeley WW; Hu F
    Acta Neuropathol; 2023 Jul; 146(1):97-119. PubMed ID: 37120788
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency.
    Frew J; Baradaran-Heravi A; Balgi AD; Wu X; Yan TD; Arns S; Shidmoossavee FS; Tan J; Jaquith JB; Jansen-West KR; Lynn FC; Gao FB; Petrucelli L; Feldman HH; Mackenzie IR; Roberge M; Nygaard HB
    Mol Neurodegener; 2020 Mar; 15(1):21. PubMed ID: 32178712
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
    Arrant AE; Filiano AJ; Patel AR; Hoffmann MQ; Boyle NR; Kashyap SN; Onyilo VC; Young AH; Roberson ED
    Neurobiol Dis; 2019 Apr; 124():152-162. PubMed ID: 30448285
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
    Martens LH; Zhang J; Barmada SJ; Zhou P; Kamiya S; Sun B; Min SW; Gan L; Finkbeiner S; Huang EJ; Farese RV
    J Clin Invest; 2012 Nov; 122(11):3955-9. PubMed ID: 23041626
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 29.