BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 33035756)

  • 1. Synthesis and evaluation of etoposide and podophyllotoxin analogs against topoisomerase IIα and HCT-116 cells.
    Murphy MB; Kumar P; Bradley AM; Barton CE; Deweese JE; Mercer SL
    Bioorg Med Chem; 2020 Nov; 28(22):115773. PubMed ID: 33035756
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.
    Yadav AA; Chee GL; Wu X; Patel D; Yalowich JC; Hasinoff BB
    Bioorg Med Chem; 2015 Jul; 23(13):3542-51. PubMed ID: 25922181
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer.
    Reddy VG; Bonam SR; Reddy TS; Akunuri R; Naidu VGM; Nayak VL; Bhargava SK; Kumar HMS; Srihari P; Kamal A
    Eur J Med Chem; 2018 Jan; 144():595-611. PubMed ID: 29289884
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors.
    Sathish M; Kavitha B; Nayak VL; Tangella Y; Ajitha A; Nekkanti S; Alarifi A; Shankaraiah N; Nagesh N; Kamal A
    Eur J Med Chem; 2018 Jan; 144():557-571. PubMed ID: 29289881
    [TBL] [Abstract][Full Text] [Related]  

  • 5. One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents.
    Shankaraiah N; Kumar NP; Amula SB; Nekkanti S; Jeengar MK; Naidu VG; Reddy TS; Kamal A
    Bioorg Med Chem Lett; 2015 Oct; 25(19):4239-44. PubMed ID: 26292628
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
    Zhao W; Chen L; Li HM; Wang DJ; Li DS; Chen T; Yuan ZP; Tang YJ
    Bioorg Med Chem; 2014 Jun; 22(11):2998-3007. PubMed ID: 24775914
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and evaluation of aroylthiourea derivatives of 4-β-amino-4'-O-demethyl-4-desoxypodophyllotoxin as novel topoisomerase II inhibitors.
    Zhao Y; Ge CW; Wu ZH; Wang CN; Fang JH; Zhu L
    Eur J Med Chem; 2011 Mar; 46(3):901-6. PubMed ID: 21277655
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 4β-[4'-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents.
    Kamal A; Suresh P; Ramaiah MJ; Srinivasa Reddy T; Kapavarapu RK; Rao BN; Imthiajali S; Lakshminarayan Reddy T; Pushpavalli SN; Shankaraiah N; Pal-Bhadra M
    Bioorg Med Chem; 2013 Sep; 21(17):5198-208. PubMed ID: 23849207
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ.
    Oviatt AA; Kuriappan JA; Minniti E; Vann KR; Onuorah P; Minarini A; De Vivo M; Osheroff N
    Bioorg Med Chem Lett; 2018 Sep; 28(17):2961-2968. PubMed ID: 30006062
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.
    Yadav AA; Wu X; Patel D; Yalowich JC; Hasinoff BB
    Bioorg Med Chem; 2014 Nov; 22(21):5935-49. PubMed ID: 25282653
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways.
    Xiao L; Zhao W; Li HM; Wan DJ; Li DS; Chen T; Tang YJ
    Eur J Med Chem; 2014 Jun; 80():267-77. PubMed ID: 24793877
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of novel podophyllotoxin analogs.
    Li J; Hua HM; Tang YB; Zhang S; Ohkoshi E; Lee KH; Xiao Zy
    Bioorg Med Chem Lett; 2012 Jul; 22(13):4293-5. PubMed ID: 22658864
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of 4β-(thiazol-2-yl)amino-4'-O-demethyl-4-deoxypodophyllotoxins as topoisomerase-II inhibitors.
    Sang CY; Tian HZ; Chen Y; Liu JF; Chen SW; Hui L
    Bioorg Med Chem Lett; 2018 Jan; 28(2):71-76. PubMed ID: 29248296
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors.
    My Van HT; Woo H; Jeong HM; Khadka DB; Yang SH; Zhao C; Jin Y; Lee ES; Youl Lee K; Kwon Y; Cho WJ
    Eur J Med Chem; 2014 Jul; 82():181-94. PubMed ID: 24904965
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development of β-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase IIα inhibition and apoptosis induction.
    Tokala R; Mahajan S; Kiranmai G; Sigalapalli DK; Sana S; John SE; Nagesh N; Shankaraiah N
    Bioorg Chem; 2021 Jan; 106():104481. PubMed ID: 33261848
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers.
    Li PH; Jiang H; Zhang WJ; Li YL; Zhao MC; Zhou W; Zhang LY; Tang YD; Dong CZ; Huang ZS; Chen HX; Du ZY
    Eur J Med Chem; 2018 Feb; 145():498-510. PubMed ID: 29335211
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II.
    Brel V; Annereau JP; Vispé S; Kruczynski A; Bailly C; Guilbaud N
    Biochem Pharmacol; 2011 Dec; 82(12):1843-52. PubMed ID: 21924246
    [TBL] [Abstract][Full Text] [Related]  

  • 18. N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase.
    Baviskar AT; Madaan C; Preet R; Mohapatra P; Jain V; Agarwal A; Guchhait SK; Kundu CN; Banerjee UC; Bharatam PV
    J Med Chem; 2011 Jul; 54(14):5013-30. PubMed ID: 21644529
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities.
    Kamal A; Kumar BA; Suresh P; Agrawal SK; Chashoo G; Singh SK; Saxena AK
    Bioorg Med Chem; 2010 Dec; 18(24):8493-500. PubMed ID: 21074444
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.
    Kamal A; Suresh P; Ramaiah MJ; Mallareddy A; Imthiajali S; Pushpavalli SN; Lavanya A; Pal-Bhadra M
    Bioorg Med Chem; 2012 Mar; 20(6):2054-66. PubMed ID: 22364746
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.