BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 33042633)

  • 1. A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.
    Sohal D; Krishnamurthi S; Tohme R; Gu X; Lindner D; Landowski TH; Pink J; Radivoyevitch T; Fada S; Lee Z; Shepard D; Khorana A; Saunthararajah Y
    Am J Cancer Res; 2020; 10(9):3047-3060. PubMed ID: 33042633
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.
    Molokie R; Lavelle D; Gowhari M; Pacini M; Krauz L; Hassan J; Ibanez V; Ruiz MA; Ng KP; Woost P; Radivoyevitch T; Pacelli D; Fada S; Rump M; Hsieh M; Tisdale JF; Jacobberger J; Phelps M; Engel JD; Saraf S; Hsu LL; Gordeuk V; DeSimone J; Saunthararajah Y
    PLoS Med; 2017 Sep; 14(9):e1002382. PubMed ID: 28880867
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A pilot clinical trial of oral tetrahydrouridine/decitabine for noncytotoxic epigenetic therapy of chemoresistant lymphoid malignancies.
    Hill B; Jagadeesh D; Pohlman B; Dean R; Parameswaran N; Chen J; Radivoyevitch T; Morrison A; Fada S; Dever M; Robinson S; Lindner D; Smith M; Saunthararajah Y
    Semin Hematol; 2021 Jan; 58(1):35-44. PubMed ID: 33509441
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Combined inhibition of histone deacetylase and cytidine deaminase improves epigenetic potency of decitabine in colorectal adenocarcinomas.
    Tang Z; Liu L; Borlak J
    Clin Epigenetics; 2023 May; 15(1):89. PubMed ID: 37208732
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacokinetics and pharmacodynamics of an oral formulation of decitabine and tetrahydrouridine.
    Lau H; Woost PG; Friedrich U; Clausen WHO; Jacobberger JW; Saunthararajah Y
    Eur J Haematol; 2023 Sep; 111(3):345-355. PubMed ID: 37417197
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine.
    Lavelle D; Vaitkus K; Ling Y; Ruiz MA; Mahfouz R; Ng KP; Negrotto S; Smith N; Terse P; Engelke KJ; Covey J; Chan KK; Desimone J; Saunthararajah Y
    Blood; 2012 Feb; 119(5):1240-7. PubMed ID: 22160381
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects.
    Ebrahem Q; Mahfouz RZ; Ng KP; Saunthararajah Y
    Oncotarget; 2012 Oct; 3(10):1137-45. PubMed ID: 23087155
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice.
    Terse P; Engelke K; Chan K; Ling Y; Sharpnack D; Saunthararajah Y; Covey JM
    Int J Toxicol; 2014; 33(2):75-85. PubMed ID: 24639139
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels.
    Funamizu N; Lacy CR; Fujita K; Furukawa K; Misawa T; Yanaga K; Manome Y
    PLoS One; 2012; 7(5):e37424. PubMed ID: 22616006
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase.
    Ferraris D; Duvall B; Delahanty G; Mistry B; Alt J; Rojas C; Rowbottom C; Sanders K; Schuck E; Huang KC; Redkar S; Slusher BB; Tsukamoto T
    J Med Chem; 2014 Mar; 57(6):2582-8. PubMed ID: 24520856
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice.
    Beumer JH; Eiseman JL; Parise RA; Florian JA; Joseph E; D'Argenio DZ; Parker RS; Kay B; Covey JM; Egorin MJ
    Cancer Chemother Pharmacol; 2008 Aug; 62(3):457-64. PubMed ID: 18008070
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Epimer interconversion, isomerization, and hydrolysis of tetrahydrouridine: implications for cytidine deaminase inhibition.
    Xiang TX; Niemi R; Bummer P; Anderson BD
    J Pharm Sci; 2003 Oct; 92(10):2027-39. PubMed ID: 14502542
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study.
    Savona MR; Odenike O; Amrein PC; Steensma DP; DeZern AE; Michaelis LC; Faderl S; Harb W; Kantarjian H; Lowder J; Oganesian A; Azab M; Garcia-Manero G
    Lancet Haematol; 2019 Apr; 6(4):e194-e203. PubMed ID: 30926081
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mycoplasma infection of cancer cells enhances anti-tumor effect of oxidized methylcytidines.
    Pang GZ; Zhao YH; Wang YX; Rong SQ; Gao H; Zhou D
    Biochem Biophys Res Commun; 2023 Sep; 672():193-200. PubMed ID: 37356286
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase.
    Kim CH; Marquez VE; Mao DT; Haines DR; McCormack JJ
    J Med Chem; 1986 Aug; 29(8):1374-80. PubMed ID: 3735306
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Combinations of tetrahydrouridine and cytosine arabinoside in mouse tumors.
    Kreis W; Hession C; Soricelli A; Scully K
    Cancer Treat Rep; 1977 Oct; 61(7):1355-64. PubMed ID: 589601
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evaluation of noncytotoxic DNMT1-depleting therapy in patients with myelodysplastic syndromes.
    Saunthararajah Y; Sekeres M; Advani A; Mahfouz R; Durkin L; Radivoyevitch T; Englehaupt R; Juersivich J; Cooper K; Husseinzadeh H; Przychodzen B; Rump M; Hobson S; Earl M; Sobecks R; Dean R; Reu F; Tiu R; Hamilton B; Copelan E; Lichtin A; Hsi E; Kalaycio M; Maciejewski J
    J Clin Invest; 2015 Mar; 125(3):1043-55. PubMed ID: 25621498
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.
    Parise RA; Egorin MJ; Eiseman JL; Joseph E; Covey JM; Beumer JH
    Rapid Commun Mass Spectrom; 2007; 21(13):1991-7. PubMed ID: 17526067
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
    Laliberté J; Marquez VE; Momparler RL
    Cancer Chemother Pharmacol; 1992; 30(1):7-11. PubMed ID: 1375134
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Optimized blood sampling with cytidine deaminase inhibitor for improved analysis of capecitabine metabolites.
    Besnard T; Renée N; Etienne-Grimaldi MC; François E; Milano G
    J Chromatogr B Analyt Technol Biomed Life Sci; 2008 Jul; 870(1):117-20. PubMed ID: 18562256
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.