These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

173 related articles for article (PubMed ID: 33051808)

  • 1. In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes.
    Docci L; Klammers F; Ekiciler A; Molitor B; Umehara K; Walter I; Krähenbühl S; Parrott N; Fowler S
    AAPS J; 2020 Oct; 22(6):131. PubMed ID: 33051808
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Construction and Verification of Physiologically Based Pharmacokinetic Models for Four Drugs Majorly Cleared by Glucuronidation: Lorazepam, Oxazepam, Naloxone, and Zidovudine.
    Docci L; Umehara K; Krähenbühl S; Fowler S; Parrott N
    AAPS J; 2020 Oct; 22(6):128. PubMed ID: 33033903
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction.
    Umehara K; Cantrill C; Wittwer MB; Di Lenarda E; Klammers F; Ekiciler A; Parrott N; Fowler S; Ullah M
    Drug Metab Dispos; 2020 Oct; 48(10):849-860. PubMed ID: 32739889
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Prediction of hepatic and intestinal glucuronidation using in vitro-in vivo extrapolation.
    Naritomi Y; Nakamori F; Furukawa T; Tabata K
    Drug Metab Pharmacokinet; 2015 Feb; 30(1):21-9. PubMed ID: 25760528
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Uridine 5'-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE).
    Gabor-Worwa E; Kowal-Chwast A; Gaud N; Gogola D; Littlewood P; Smoluch M; Brzózka K; Kus K
    Eur J Drug Metab Pharmacokinet; 2024 May; 49(3):393-403. PubMed ID: 38642299
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.
    Kratochwil NA; Meille C; Fowler S; Klammers F; Ekiciler A; Molitor B; Simon S; Walter I; McGinnis C; Walther J; Leonard B; Triyatni M; Javanbakht H; Funk C; Schuler F; Lavé T; Parrott NJ
    AAPS J; 2017 Mar; 19(2):534-550. PubMed ID: 28050713
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Albumin-Mediated Uptake Improves Human Clearance Prediction for Hepatic Uptake Transporter Substrates Aiding a Mechanistic In Vitro-In Vivo Extrapolation (IVIVE) Strategy in Discovery Research.
    Li N; Badrinarayanan A; Ishida K; Li X; Roberts J; Wang S; Hayashi M; Gupta A
    AAPS J; 2020 Nov; 23(1):1. PubMed ID: 33196949
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac.
    Chan TS; Yu H; Moore A; Khetani SR; Tweedie D
    Drug Metab Dispos; 2013 Dec; 41(12):2024-32. PubMed ID: 23959596
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes.
    Nishimuta H; Watanabe T; Bando K
    AAPS J; 2019 Jan; 21(2):20. PubMed ID: 30673906
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Evaluation of Erythromycin as a Tool to Assess CYP3A Contribution of Low Clearance Compounds in a Long-Term Hepatocyte Culture.
    Chan TS; Scaringella YS; Raymond K; Taub ME
    Drug Metab Dispos; 2020 Aug; 48(8):690-697. PubMed ID: 32503882
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding.
    Da-Silva F; Boulenc X; Vermet H; Compigne P; Gerbal-Chaloin S; Daujat-Chavanieu M; Klieber S; Poulin P
    J Pharm Sci; 2018 Jul; 107(7):1957-1972. PubMed ID: 29524447
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.
    Miners JO; Knights KM; Houston JB; Mackenzie PI
    Biochem Pharmacol; 2006 May; 71(11):1531-9. PubMed ID: 16455060
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches.
    Izumi S; Nozaki Y; Komori T; Takenaka O; Maeda K; Kusuhara H; Sugiyama Y
    J Pharm Sci; 2017 Sep; 106(9):2678-2687. PubMed ID: 28238896
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Drug Design and Success of Prospective Mouse In Vitro-In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CL
    Manevski N; Umehara K; Parrott N
    Mol Pharm; 2023 Jul; 20(7):3438-3459. PubMed ID: 37235687
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.
    Kilford PJ; Stringer R; Sohal B; Houston JB; Galetin A
    Drug Metab Dispos; 2009 Jan; 37(1):82-9. PubMed ID: 18832476
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac.
    Chan TS; Yu H; Moore A; Khetani SR; Tweedie D
    Drug Metab Dispos; 2019 Jan; 47(1):58-66. PubMed ID: 30552098
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance.
    Williamson B; Harlfinger S; McGinnity DF
    Drug Metab Dispos; 2020 Nov; 48(11):1137-1146. PubMed ID: 32847864
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors.
    den Braver-Sewradj SP; den Braver MW; Baze A; Decorde J; Fonsi M; Bachellier P; Vermeulen NPE; Commandeur JNM; Richert L; Vos JC
    Eur J Pharm Sci; 2017 Nov; 109():96-110. PubMed ID: 28778465
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance.
    Cubitt HE; Houston JB; Galetin A
    Pharm Res; 2009 May; 26(5):1073-83. PubMed ID: 19184618
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Comparison of In Vitro to In Vivo Extrapolation Approaches for Predicting Transporter-Mediated Hepatic Uptake Clearance Using Suspended Rat Hepatocytes.
    Li N; Badrinarayanan A; Li X; Roberts J; Hayashi M; Virk M; Gupta A
    Drug Metab Dispos; 2020 Oct; 48(10):861-872. PubMed ID: 32759366
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.