BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

154 related articles for article (PubMed ID: 33054085)

  • 1. ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies.
    Botrugno OA; Bianchessi S; Zambroni D; Frenquelli M; Belloni D; Bongiovanni L; Girlanda S; Di Terlizzi S; Ferrarini M; Ferrero E; Ponzoni M; Marcatti M; Tonon G
    Haematologica; 2020 Oct; 105(10):2440-2447. PubMed ID: 33054085
    [TBL] [Abstract][Full Text] [Related]  

  • 2. An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.
    Sousa MM; Zub KA; Aas PA; Hanssen-Bauer A; Demirovic A; Sarno A; Tian E; Liabakk NB; Slupphaug G
    PLoS One; 2013; 8(2):e55493. PubMed ID: 23405159
    [TBL] [Abstract][Full Text] [Related]  

  • 3. PJ34, a poly(ADP-ribose) polymerase (PARP) inhibitor, reverses melphalan-resistance and inhibits repair of DNA double-strand breaks by targeting the FA/BRCA pathway in multidrug resistant multiple myeloma cell line RPMI8226/R.
    Xiong T; Wei H; Chen X; Xiao H
    Int J Oncol; 2015 Jan; 46(1):223-32. PubMed ID: 25351371
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma.
    Xing L; Lin L; Yu T; Li Y; Cho SF; Liu J; Wen K; Hsieh PA; Kinneer K; Munshi N; Anderson KC; Tai YT
    Leukemia; 2020 Aug; 34(8):2150-2162. PubMed ID: 32060401
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function.
    Menezes DL; Holt J; Tang Y; Feng J; Barsanti P; Pan Y; Ghoddusi M; Zhang W; Thomas G; Holash J; Lees E; Taricani L
    Mol Cancer Res; 2015 Jan; 13(1):120-9. PubMed ID: 25232030
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.
    Cui Y; Palii SS; Innes CL; Paules RS
    Cell Cycle; 2014; 13(22):3541-50. PubMed ID: 25483091
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma.
    Cottini F; Hideshima T; Suzuki R; Tai YT; Bianchini G; Richardson PG; Anderson KC; Tonon G
    Cancer Discov; 2015 Sep; 5(9):972-87. PubMed ID: 26080835
    [TBL] [Abstract][Full Text] [Related]  

  • 8. PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness.
    Gralewska P; Gajek A; Marczak A; Mikuła M; Ostrowski J; Śliwińska A; Rogalska A
    Int J Mol Sci; 2020 Dec; 21(24):. PubMed ID: 33352723
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors.
    Turchick A; Zimmermann A; Chiu LY; Dahmen H; Elenbaas B; Zenke FT; Blaukat A; Vassilev LT
    Mol Cancer Ther; 2023 Jul; 22(7):859-872. PubMed ID: 37079339
    [TBL] [Abstract][Full Text] [Related]  

  • 10. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype.
    Soriani A; Zingoni A; Cerboni C; Iannitto ML; Ricciardi MR; Di Gialleonardo V; Cippitelli M; Fionda C; Petrucci MT; Guarini A; Foà R; Santoni A
    Blood; 2009 Apr; 113(15):3503-11. PubMed ID: 19098271
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples.
    Spanswick VJ; Lowe HL; Newton C; Bingham JP; Bagnobianchi A; Kiakos K; Craddock C; Ledermann JA; Hochhauser D; Hartley JA
    BMC Cancer; 2012 Sep; 12():436. PubMed ID: 23020514
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer.
    Nam AR; Jin MH; Park JE; Bang JH; Oh DY; Bang YJ
    Cancer Res Treat; 2019 Jul; 51(3):1167-1179. PubMed ID: 30514066
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting ATM and ATR for cancer therapeutics: Inhibitors in clinic.
    Priya B; Ravi S; Kirubakaran S
    Drug Discov Today; 2023 Aug; 28(8):103662. PubMed ID: 37302542
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments.
    Mohni KN; Thompson PS; Luzwick JW; Glick GG; Pendleton CS; Lehmann BD; Pietenpol JA; Cortez D
    PLoS One; 2015; 10(5):e0125482. PubMed ID: 25965342
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Ribonucleotide Reductase Catalytic Subunit M1 (RRM1) as a Novel Therapeutic Target in Multiple Myeloma.
    Sagawa M; Ohguchi H; Harada T; Samur MK; Tai YT; Munshi NC; Kizaki M; Hideshima T; Anderson KC
    Clin Cancer Res; 2017 Sep; 23(17):5225-5237. PubMed ID: 28442502
    [No Abstract]   [Full Text] [Related]  

  • 16. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.
    Vendetti FP; Lau A; Schamus S; Conrads TP; O'Connor MJ; Bakkenist CJ
    Oncotarget; 2015 Dec; 6(42):44289-305. PubMed ID: 26517239
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer.
    Gout J; Perkhofer L; Morawe M; Arnold F; Ihle M; Biber S; Lange S; Roger E; Kraus JM; Stifter K; Hahn SA; Zamperone A; Engleitner T; Müller M; Walter K; Rodriguez-Aznar E; Sainz B; Hermann PC; Hessmann E; Müller S; Azoitei N; Lechel A; Liebau S; Wagner M; Simeone DM; Kestler HA; Seufferlein T; Wiesmüller L; Rad R; Frappart PO; Kleger A
    Gut; 2021 Apr; 70(4):743-760. PubMed ID: 32873698
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The identification of the ATR inhibitor VE-822 as a therapeutic strategy for enhancing cisplatin chemosensitivity in esophageal squamous cell carcinoma.
    Shi Q; Shen LY; Dong B; Fu H; Kang XZ; Yang YB; Dai L; Yan WP; Xiong HC; Liang Z; Chen KN
    Cancer Lett; 2018 Sep; 432():56-68. PubMed ID: 29890208
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells.
    Chen Q; Van der Sluis PC; Boulware D; Hazlehurst LA; Dalton WS
    Blood; 2005 Jul; 106(2):698-705. PubMed ID: 15802532
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells.
    Ray A; Ravillah D; Das DS; Song Y; Nordström E; Gullbo J; Richardson PG; Chauhan D; Anderson KC
    Br J Haematol; 2016 Aug; 174(3):397-409. PubMed ID: 27098276
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.