250 related articles for article (PubMed ID: 33060361)
1. The GATOR-Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids.
Hesketh GG; Papazotos F; Pawling J; Rajendran D; Knight JDR; Martinez S; Taipale M; Schramek D; Dennis JW; Gingras AC
Science; 2020 Oct; 370(6514):351-356. PubMed ID: 33060361
[TBL] [Abstract][Full Text] [Related]
2. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
Oshiro N; Rapley J; Avruch J
J Biol Chem; 2014 Jan; 289(5):2658-74. PubMed ID: 24337580
[TBL] [Abstract][Full Text] [Related]
3. Macropinocytosis, mTORC1 and cellular growth control.
Yoshida S; Pacitto R; Inoki K; Swanson J
Cell Mol Life Sci; 2018 Apr; 75(7):1227-1239. PubMed ID: 29119228
[TBL] [Abstract][Full Text] [Related]
4. Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).
Shibutani S; Okazaki H; Iwata H
J Biol Chem; 2017 Nov; 292(44):18052-18061. PubMed ID: 28808055
[TBL] [Abstract][Full Text] [Related]
5. SNAT7 regulates mTORC1 via macropinocytosis.
Meng D; Yang Q; Jeong MH; Curukovic A; Tiwary S; Melick CH; Lama-Sherpa TD; Wang H; Huerta-Rosario M; Urquhart G; Zacharias LG; Lewis C; DeBerardinis RJ; Jewell JL
Proc Natl Acad Sci U S A; 2022 May; 119(20):e2123261119. PubMed ID: 35561222
[TBL] [Abstract][Full Text] [Related]
6. Glutamine and asparagine activate mTORC1 independently of Rag GTPases.
Meng D; Yang Q; Wang H; Melick CH; Navlani R; Frank AR; Jewell JL
J Biol Chem; 2020 Mar; 295(10):2890-2899. PubMed ID: 32019866
[TBL] [Abstract][Full Text] [Related]
7. Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.
Jung J; Genau HM; Behrends C
Mol Cell Biol; 2015 Jul; 35(14):2479-94. PubMed ID: 25963655
[TBL] [Abstract][Full Text] [Related]
8. A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Bar-Peled L; Chantranupong L; Cherniack AD; Chen WW; Ottina KA; Grabiner BC; Spear ED; Carter SL; Meyerson M; Sabatini DM
Science; 2013 May; 340(6136):1100-6. PubMed ID: 23723238
[TBL] [Abstract][Full Text] [Related]
9. Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Parmigiani A; Nourbakhsh A; Ding B; Wang W; Kim YC; Akopiants K; Guan KL; Karin M; Budanov AV
Cell Rep; 2014 Nov; 9(4):1281-91. PubMed ID: 25457612
[TBL] [Abstract][Full Text] [Related]
10. Sensors for the mTORC1 pathway regulated by amino acids.
Li XZ; Yan XH
J Zhejiang Univ Sci B; 2019 Sept.; 20(9):699-712. PubMed ID: 31379141
[TBL] [Abstract][Full Text] [Related]
11. Recent advances in understanding of amino acid signaling to mTORC1 activation.
Zhuang Y; Wang XX; He J; He S; Yin Y
Front Biosci (Landmark Ed); 2019 Mar; 24(5):971-982. PubMed ID: 30844724
[TBL] [Abstract][Full Text] [Related]
12. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
Lee M; Kim JH; Yoon I; Lee C; Fallahi Sichani M; Kang JS; Kang J; Guo M; Lee KY; Han G; Kim S; Han JM
Proc Natl Acad Sci U S A; 2018 Jun; 115(23):E5279-E5288. PubMed ID: 29784813
[TBL] [Abstract][Full Text] [Related]
13. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
Zoncu R; Bar-Peled L; Efeyan A; Wang S; Sancak Y; Sabatini DM
Science; 2011 Nov; 334(6056):678-83. PubMed ID: 22053050
[TBL] [Abstract][Full Text] [Related]
14. A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.
Lawrence RE; Cho KF; Rappold R; Thrun A; Tofaute M; Kim DJ; Moldavski O; Hurley JH; Zoncu R
Nat Cell Biol; 2018 Sep; 20(9):1052-1063. PubMed ID: 30061680
[TBL] [Abstract][Full Text] [Related]
15. Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
Mutvei AP; Nagiec MJ; Hamann JC; Kim SG; Vincent CT; Blenis J
Nat Commun; 2020 Mar; 11(1):1416. PubMed ID: 32184389
[TBL] [Abstract][Full Text] [Related]
16. SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.
Kim YM; Stone M; Hwang TH; Kim YG; Dunlevy JR; Griffin TJ; Kim DH
Mol Cell; 2012 Jun; 46(6):833-46. PubMed ID: 22575674
[TBL] [Abstract][Full Text] [Related]
17. Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids.
Frias MA; Mukhopadhyay S; Lehman E; Walasek A; Utter M; Menon D; Foster DA
J Biol Chem; 2020 Jan; 295(1):263-274. PubMed ID: 31767684
[TBL] [Abstract][Full Text] [Related]
18. MORG1 limits mTORC1 signaling by inhibiting Rag GTPases.
Abudu YP; Kournoutis A; Brenne HB; Lamark T; Johansen T
Mol Cell; 2024 Feb; 84(3):552-569.e11. PubMed ID: 38103557
[TBL] [Abstract][Full Text] [Related]
19. Rag GTPase in amino acid signaling.
Kim J; Kim E
Amino Acids; 2016 Apr; 48(4):915-928. PubMed ID: 26781224
[TBL] [Abstract][Full Text] [Related]
20. An interdomain hydrogen bond in the Rag GTPases maintains stable mTORC1 signaling in sensing amino acids.
Egri SB; Shen K
J Biol Chem; 2021 Jul; 297(1):100861. PubMed ID: 34116056
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]