BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

240 related articles for article (PubMed ID: 33074285)

  • 1. Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks.
    Stewart JA; Schauer G; Bhagwat AS
    Nucleic Acids Res; 2020 Nov; 48(20):e118. PubMed ID: 33074285
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases.
    Wong L; Sami A; Chelico L
    Nucleic Acids Res; 2022 Nov; 50(21):12039-12057. PubMed ID: 36444883
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.
    Butt Y; Sakhtemani R; Mohamad-Ramshan R; Lawrence MS; Bhagwat AS
    Nat Commun; 2024 Mar; 15(1):2369. PubMed ID: 38499553
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli.
    Bhagwat AS; Hao W; Townes JP; Lee H; Tang H; Foster PL
    Proc Natl Acad Sci U S A; 2016 Feb; 113(8):2176-81. PubMed ID: 26839411
    [TBL] [Abstract][Full Text] [Related]  

  • 5. HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation.
    Mehta KPM; Lovejoy CA; Zhao R; Heintzman DR; Cortez D
    Cell Rep; 2020 Jun; 31(9):107705. PubMed ID: 32492421
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Single-stranded DNA binding proteins influence APOBEC3A substrate preference.
    Brown AL; Collins CD; Thompson S; Coxon M; Mertz TM; Roberts SA
    Sci Rep; 2021 Oct; 11(1):21008. PubMed ID: 34697369
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A Tumor-Promoting Phorbol Ester Causes a Large Increase in APOBEC3A Expression and a Moderate Increase in APOBEC3B Expression in a Normal Human Keratinocyte Cell Line without Increasing Genomic Uracils.
    Siriwardena SU; Perera MLW; Senevirathne V; Stewart J; Bhagwat AS
    Mol Cell Biol; 2019 Jan; 39(1):. PubMed ID: 30348839
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing.
    Sakhtemani R; Senevirathne V; Stewart J; Perera MLW; Pique-Regi R; Lawrence MS; Bhagwat AS
    J Biol Chem; 2019 Oct; 294(41):15037-15051. PubMed ID: 31431505
    [TBL] [Abstract][Full Text] [Related]  

  • 9. N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions.
    Weiser BP; Rodriguez G; Cole PA; Stivers JT
    Nucleic Acids Res; 2018 Aug; 46(14):7169-7178. PubMed ID: 29917162
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations.
    Butt Y; Sakhtemani R; Mohamad-Ramshan R; Lawrence MS; Bhagwat AS
    bioRxiv; 2023 Aug; ():. PubMed ID: 37577595
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.
    Adolph MB; Love RP; Feng Y; Chelico L
    Nucleic Acids Res; 2017 Nov; 45(20):11925-11940. PubMed ID: 28981865
    [TBL] [Abstract][Full Text] [Related]  

  • 12. APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.
    Hoopes JI; Cortez LM; Mertz TM; Malc EP; Mieczkowski PA; Roberts SA
    Cell Rep; 2016 Feb; 14(6):1273-1282. PubMed ID: 26832400
    [TBL] [Abstract][Full Text] [Related]  

  • 13. RPA guides UNG to uracil in ssDNA to facilitate antibody class switching and repair of mutagenic uracil at the replication fork.
    Hayran AB; Liabakk NB; Aas PA; Kusnierczyk A; Vågbø CB; Sarno A; Iveland TS; Chawla K; Zahn A; Di Noia JM; Slupphaug G; Kavli B
    Nucleic Acids Res; 2024 Jan; 52(2):784-800. PubMed ID: 38000394
    [TBL] [Abstract][Full Text] [Related]  

  • 14. APOBEC3A damages the cellular genome during DNA replication.
    Green AM; Landry S; Budagyan K; Avgousti DC; Shalhout S; Bhagwat AS; Weitzman MD
    Cell Cycle; 2016; 15(7):998-1008. PubMed ID: 26918916
    [TBL] [Abstract][Full Text] [Related]  

  • 15. RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork.
    Kavli B; Iveland TS; Buchinger E; Hagen L; Liabakk NB; Aas PA; Obermann TS; Aachmann FL; Slupphaug G
    Nucleic Acids Res; 2021 Apr; 49(7):3948-3966. PubMed ID: 33784377
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops.
    Sakhtemani R; Perera MLW; Hübschmann D; Siebert R; Lawrence MS; Bhagwat AS
    Nucleic Acids Res; 2022 May; 50(9):5145-5157. PubMed ID: 35524550
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.
    Love RP; Xu H; Chelico L
    J Biol Chem; 2012 Aug; 287(36):30812-22. PubMed ID: 22822074
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA.
    Lada AG; Waisertreiger IS; Grabow CE; Prakash A; Borgstahl GE; Rogozin IB; Pavlov YI
    PLoS One; 2011; 6(9):e24848. PubMed ID: 21935481
    [TBL] [Abstract][Full Text] [Related]  

  • 19. APOBEC3A induces DNA gaps through PRIMPOL and confers gap-associated therapeutic vulnerability.
    Kawale AS; Ran X; Patel PS; Saxena S; Lawrence MS; Zou L
    Sci Adv; 2024 Jan; 10(3):eadk2771. PubMed ID: 38241374
    [TBL] [Abstract][Full Text] [Related]  

  • 20. APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.
    Seplyarskiy VB; Soldatov RA; Popadin KY; Antonarakis SE; Bazykin GA; Nikolaev SI
    Genome Res; 2016 Feb; 26(2):174-82. PubMed ID: 26755635
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.