601 related articles for article (PubMed ID: 33076948)
1. Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.
Serneels L; T'Syen D; Perez-Benito L; Theys T; Holt MG; De Strooper B
Mol Neurodegener; 2020 Oct; 15(1):60. PubMed ID: 33076948
[TBL] [Abstract][Full Text] [Related]
2. Aβ43 levels determine the onset of pathological amyloid deposition.
Tambini MD; Yin T; Yesiltepe M; Breuillaud L; Zehntner SP; d'Abramo C; Giliberto L; D'Adamio L
J Biol Chem; 2023 Jul; 299(7):104868. PubMed ID: 37257821
[TBL] [Abstract][Full Text] [Related]
3. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
Kimura A; Hata S; Suzuki T
J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
[TBL] [Abstract][Full Text] [Related]
4. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
5. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
Guo Q; Li H; Cole AL; Hur JY; Li Y; Zheng H
PLoS One; 2013; 8(11):e80706. PubMed ID: 24278307
[TBL] [Abstract][Full Text] [Related]
6. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.
Johnson ECB; Ho K; Yu GQ; Das M; Sanchez PE; Djukic B; Lopez I; Yu X; Gill M; Zhang W; Paz JT; Palop JJ; Mucke L
Mol Neurodegener; 2020 Sep; 15(1):53. PubMed ID: 32921309
[TBL] [Abstract][Full Text] [Related]
7. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
[TBL] [Abstract][Full Text] [Related]
8. Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations.
Pimenova AA; Goate AM
Neurobiol Dis; 2020 May; 138():104785. PubMed ID: 32032730
[TBL] [Abstract][Full Text] [Related]
9. Beta-secretase/BACE1 promotes APP endocytosis and processing in the endosomes and on cell membrane.
Wang M; Jing T; Wang X; Yao D
Neurosci Lett; 2018 Oct; 685():63-67. PubMed ID: 30120949
[TBL] [Abstract][Full Text] [Related]
10. Knock-in rats with homozygous
Tambini MD; D'Adamio L
J Biol Chem; 2020 May; 295(21):7442-7451. PubMed ID: 32265300
[TBL] [Abstract][Full Text] [Related]
11. BACE1: the beta-secretase enzyme in Alzheimer's disease.
Vassar R
J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
[TBL] [Abstract][Full Text] [Related]
12. Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion.
Pagnon de la Vega M; Syvänen S; Giedraitis V; Hooley M; Konstantinidis E; Meier SR; Rokka J; Eriksson J; Aguilar X; Spires-Jones TL; Lannfelt L; Nilsson LNG; Erlandsson A; Hultqvist G; Ingelsson M; Sehlin D
Acta Neuropathol Commun; 2024 Feb; 12(1):22. PubMed ID: 38317196
[TBL] [Abstract][Full Text] [Related]
13. Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages.
Devi L; Ohno M
Neuroscience; 2015 Oct; 307():128-37. PubMed ID: 26314636
[TBL] [Abstract][Full Text] [Related]
14. BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
Zhang S; Wang Z; Cai F; Zhang M; Wu Y; Zhang J; Song W
J Neurosci; 2017 Jul; 37(29):6915-6925. PubMed ID: 28626014
[TBL] [Abstract][Full Text] [Related]
15. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
Pinnix I; Ghiso JA; Pappolla MA; Sambamurti K
Am J Geriatr Psychiatry; 2013 May; 21(5):474-83. PubMed ID: 23570890
[TBL] [Abstract][Full Text] [Related]
16. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein.
Maloney JA; Bainbridge T; Gustafson A; Zhang S; Kyauk R; Steiner P; van der Brug M; Liu Y; Ernst JA; Watts RJ; Atwal JK
J Biol Chem; 2014 Nov; 289(45):30990-1000. PubMed ID: 25253696
[TBL] [Abstract][Full Text] [Related]
17. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
[TBL] [Abstract][Full Text] [Related]
18. Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease.
Blain JF; Bursavich MG; Freeman EA; Hrdlicka LA; Hodgdon HE; Chen T; Costa DE; Harrison BA; Kapadnis S; Murphy DA; Nolan S; Tu Z; Tang C; Burnett DA; Patzke H; Koenig G
Alzheimers Res Ther; 2016 Aug; 8(1):34. PubMed ID: 27572246
[TBL] [Abstract][Full Text] [Related]
19. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
Zhang C; Browne A; Kim DY; Tanzi RE
Curr Alzheimer Res; 2010 Feb; 7(1):21-6. PubMed ID: 20205669
[TBL] [Abstract][Full Text] [Related]
20. Berberine Alleviates Amyloid-Beta Pathology in the Brain of APP/PS1 Transgenic Mice via Inhibiting β/γ-Secretases Activity and Enhancing α-Secretases.
Cai Z; Wang C; He W; Chen Y
Curr Alzheimer Res; 2018; 15(11):1045-1052. PubMed ID: 29962345
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
